Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study aimed to examine demographic, lifestyle, mental health and personality factors associated with illicit recreational drug use, heavy alcohol consumption and smoking in a community-based population sample. A postal questionnaire survey was conducted of people who were selected at random from the Electoral registers of Cardiff and Merthyr Tydfil. Illicit drug use was associated with risk taking, neuroticism, being male, having a higher education qualification, not being married, being unemployed, being aged under 25 years, smoking, heavy alcohol consumption and living in Cardiff. Smoking was associated with anxiety, depression, being female, lower income and educational qualifications, looking after the family or home, being aged over 25 years, illicit drug use and heavy alcohol use. Heavy alcohol consumption was associated with not being depressed, experiencing sleeping problems, risk taking, being male, higher income, no higher educational qualification, not being married, being a student, being aged under 25 years, smoking and illicit drug use. Illicit drug use, smoking and heavy alcohol use were strongly associated with each other. Illicit drug use was associated with alcohol use and, to an even greater extent, with smoking. Illicit drug and alcohol use were associated with similar characteristics, but smoking was associated with a rather different demographic combination.
 ...
PMID:Factors associated with recreational drug use. 1526 Sep 13

The use of antidepressant pharmacotherapy to treat patients with co-occurring depression and alcohol dependence is controversial. There is a stigma attached to giving medications to alcohol-dependent persons. Also, empirical evidence is sparse and inconsistent, which discourages the use of antidepressants in these patients. Historically, it has been a challenge to accurately diagnose a depressive disorder in the presence of alcohol dependence. In addition, early clinical studies were fraught with methodological problems; however, improved diagnostic assessments are now available, and in the last decade, results from well-controlled trials appear to support the use of antidepressants in this patient population in the specific role of relieving depressive symptoms. The majority of these trials also demonstrate that antidepressants have relatively little impact on reducing heavy drinking in this patient population, even though the medications reduce depressive symptoms. Newer approaches to treating patients with co-occurring depression and alcohol dependence suggest adding to the antidepressant a pharmacotherapy that directly impacts drinking. The findings from this review better define the action of antidepressants in patients with co-occurring depression and alcohol dependence as specific to reducing depressive symptoms, and these medications and their action on mood have little impact on treating the co-occurring alcohol dependence.
 ...
PMID:Antidepressant treatment of co-occurring depression and alcohol dependence. 1555 24

The relationship between dieting and bingeing severity and alcohol use was studied in a sample of women in their first year of college (n = 1384). The study was designed to replicate and extend earlier findings of a graded positive relationship between the dieting and bingeing severity and the frequency, intensity, and negative consequences of alcohol use in young women, while adjusting for known predictors of alcohol use. Prevalence of past month alcohol use, drinking enough to get high on half or more drinking occasions, and heavy drinking (>or= five drinks in a row) in these women were positively associated with dieting and bingeing severity in a graded manner across the entire range of these behaviors. Dieting and bingeing severity was also more closely associated with the frequency and intensity of alcohol use than measures of depression, parents' drinking level, and early age of first drink. Finally, dieting and bingeing severity was positively associated with the prevalence of negative consequences of alcohol use, such as blackouts and unintended sexual activity. These results suggest that the dysfunctional eating behaviors often associated with dieting could also be associated with dysfunctional alcohol use.
 ...
PMID:Pathological dieting and alcohol use in college women--a continuum of behaviors. 1556 10

Disease processes or events that accompany acute alcohol withdrawal (AW) can cause significant illness and death. Some patients experience seizures, which may increase in severity with subsequent AW episodes. Another potential AW complication is delirium tremens, characterized by hallucinations, mental confusion, and disorientation. Cognitive impairment and delirium may lead to a chronic memory disorder (i.e., Wernicke-Korsakoff syndrome). Psychiatric problems associated with withdrawal include anxiety, depression, and sleep disturbance. In addition, alterations in physiology, mood, and behavior may persist after acute withdrawal has subsided, motivating relapse to heavy drinking. Recent advances in neurobiology may support the development of improved medications to decrease the risk of AW complications and support long-term sobriety.
 ...
PMID:Complications of alcohol withdrawal: pathophysiological insights. 1570 35

In this cross-sectional study, main and moderated relationships between 5 job stressors and alcohol consumption, drug use, and depression were examined using data from a community sample of 583 young adults (mean age = 23.68 years). Analyses revealed a few direct associations between high job boredom, low skill variety, and low autonomy and depression measures and heavy alcohol use. There were no direct relationships between job stress and binge drinking, alcohol consumption, drug use, or heavy drug use. In a few cases, job stress-outcome relationships were moderated by intrinsic job motivation or gender. The findings supported a specificity-of-effects hypothesis and underscored the need for examining the processes linking occupational stress to substance use and depression.
 ...
PMID:Work stress, substance use, and depression among young adult workers: an examination of main and moderator effect model. 1582 20

The purpose of this study was to determine differences in reported alcohol use and depressive symptomatology among a sample of 524 African-American and Caucasian adolescents. Of specific interest was determining if ethnicity, gender, and age predicted severity of scores obtained on the Reynolds Adolescent Depression Scale (RADS) and Adolescent Drinking Index (ADI). Extreme groups were formed using upper (> 75%) and lower (< 25%) quartiles. Three other groups were formed using each instrument's normatively derived cutoff scores: depressed only (RADS > 77), heavy drinking (ADI > 16) and mixed (RADS > 77, ADI > 16). Several results were obtained. First, Caucasians obtained significantly higher scores on the ADI than African-Americans, although no differences were obtained for the RADS. Females scored higher on the RADS but lower on the ADI than males. In terms of extreme scores, females were less likely to belong to the severe depression group, while older adolescents in general and African-Americans in particular had a greater probability of belonging to the heavy-drinking group. Finally, using RADS and ADI cutoff scores, females were less likely than males to belong to the depression only group as were African-Americans. Older adolescents, in general, and African-Americans in particular had a greater probability of belonging to the mixed group than did their counterparts.
 ...
PMID:Alcohol use and depression among African-American and Caucasian adolescents. 1586 19

This article describes the prevalence of heavy drinking among the Canadian population and the prevalence of alcohol dependence among heavy drinkers aged 18 or older. It also examines the association of depression to alcohol dependence among the latter group and the correlates of depression and alcohol dependence comorbidity. The data are from a national representative sample of the Canadian population in 2000/01. One in five current drinkers aged 18 or older was classified as a regular heavy drinker. This constituted a significant increase of approximately 2% in the prevalence of heavy drinking from 1996/97 to 2000/01 in Canada (p<0.001). Although men were more likely to be regular heavy drinkers (29.0%) than women (11.1%), male and female heavy drinkers were about equally as likely to be classified as alcohol dependent (11.6% and 11.1%, respectively). While the prevalence of alcohol dependence among men has remained stable, it has decreased by almost 4% among women (p<0.05). Among persons who have experienced a depressive episode in the year prior to their 2000/01 interview, the prevalence of alcohol dependence was estimated at 32.3% while it was 9.5% for persons without depression. When several indicators believed to be risk factors for alcohol dependence including personal characteristics, psychosocial factors, lifestyle behaviours and physical health were included in the logistic regression models, the marked difference in alcohol dependence among depressed and non-depressed heavy drinkers remained. The former had 3.6 times the odds of being classified as alcohol dependent compared to the latter (CI=2.9, 4.3). When the same personal, psychosocial, lifestyle and physical health measures were used to explain comorbidity of depression and alcohol dependence, perceived stress was the only factor that was consistently associated with comorbidity among both men and women.
 ...
PMID:Alcohol dependence and depression among heavy drinkers in Canada. 1586 34

This study delineated patterns of alcohol use 1 year after traumatic brain injury (TBI) in a large, population-based, epidemiological, nonclinical sample, and identified predictors of heavy alcohol use in these individuals. Participants were 1,606 adults identified by review of a South Carolina statewide hospital discharge data set, on the basis of satisfying the Centers for Disease Control case definition of TBI, and were interviewed by telephone 1 year after TBI-related discharge. Alcohol use in the month prior to interview was classified according to categories from the Quantity-Frequency-Variability Index; heavy drinking was defined as nearly daily use with > or = 5 drinks at least occasionally, or at least three occasions with > or = 5 drinks. A polychotomous logistic regression with 3 response levels (heavy, moderate, and abstinent/infrequent/light drinking) was used to identify predictors of heavy drinking. Heavy drinking in the month prior to interview was reported by 15.4% of participants, while 14.3% reported moderate drinking and 70.3% reported abstinence or light/infrequent drinking. Risk factors for heavy drinking included male gender, younger age, history of substance abuse prior to TBI, diagnosis of depression since TBI, fair/moderate mental health, and better physical functioning. There was no association between drinking patterns and TBI severity.
 ...
PMID:Patterns of alcohol use 1 year after traumatic brain injury: a population-based, epidemiological study. 1589 8

Studies show that residents of disadvantaged neighborhoods drink more heavily than residents of more affluent neighborhoods. However, explanations for this association are not well developed. Using data collected from a sample of low-income women with children from Boston, Chicago, and San Antonio, we explore the possibility that perceptions of neighborhood disorder encourage heavy drinking. Drawing on Conger's (Q. J. Stud. Alcohol 17 (1956) 296) tension reduction hypothesis, we propose that the stress of living in a neighborhood characterized by problems with drugs, crime, teen pregnancy, unemployment, idle youth, abandoned houses, and unresponsive police can be psychologically distressing and lead some people to consume alcohol as a means of palliative escape, to regulate feelings of anxiety and depression. In support of the tension reduction hypothesis, we find that the positive association between neighborhood disorder and heavy drinking is largely mediated by anxiety and depression.
 ...
PMID:Neighborhood disorder, psychological distress, and heavy drinking. 1595 98

This study assesses the prevalence and correlates of interpersonal violence victimization in a cohort of 493 male and 220 female junior Navy personnel who participated in a cross-sectional follow-up study on health-related behaviors. Survey data were obtained during 2000 about past-year prevalence of physical violence and sexual victimization. Chi-square tests of independence and multivariable logistic regression analyses were employed to estimate prevalence rates and to assess correlates of interpersonal violence. No gender differences were found for rates of violence victimization (16.4%) or sexual victimization (4.5%). Significant correlates of interpersonal violence victimization among males were depression and tobacco use; among females, significant correlates were depression and frequent heavy drinking. Findings suggest that large numbers of young enlisted adults serving in the military may be victims of interpersonal violence.
 ...
PMID:Prevalence and correlates of interpersonal violence victimization in a junior enlisted Navy cohort. 1646 45


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>