Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred eight-seven workers (mean age +/- SD; 42 +/- 8.8 years) in two paint manufacturing plants were examined to determine if sustained low-level exposure to mixed organic solvents resulted in the painters' syndrome (a psycho-organic syndrome). The test battery consisted of a medical and occupational questionnaire, the Present State Examination, the Zung Depression Scale, the Scandinavian Questionnaire 16, a neuropsychological battery, and vibration thresholds. Solvent exposure, expressed as total hydrocarbon of combined selected solvents, was quantitated using 13-15 years of personal breathing zone samplings. Linear regression analysis controlling for several confounding variables demonstrated significant correlations between increasing exposure to mixed organic solvents and neurobehavioral performance for vibration threshold and several neuropsychological tests. Dose-related effects of chronic solvent exposure on neurobehavioral outcomes (all subclinical) were shown, but "typical" symptoms characteristic of the painter's syndrome were not found.
 ...
PMID:Dose-related subclinical neurobehavioral effects of chronic exposure to low levels of organic solvents. 165 94

Elderly hypertensive patients with psycho-organic syndrome were treated with nicardipine (40-60 mg daily) alone or combined with hydrochlorothiazide (30 mg). This treatment led not only to a significant reduction in blood pressure but also to improvement in the score of the scales used for psychogeriatric evaluation (SCAG = Sandoz Geriatric Assessment Scale and HAM-D = Hamilton Rating Scale for Depression). These findings appear to confirm the possibility to consider nicardipine a drug of first choice for the treatment of arterial hypertension in the elderly with psycho-organic syndrome.
 ...
PMID:[Nicardipine in the therapy of arterial hypertension in elderly patients with the psycho-organic syndrome. Report on the results of the clinical study]. 252 91

Involutional depression is often the first symptom of a psycho-organic syndrome or dementia and may not present overt symptoms itself; these depressive states have been variously classified by different schools in various countries. The hypothesis of catecholamine and indolamine in the aetiopathogenic agent is oversimplistic and the theory that abnormal receptor hypersensitivity is the cause of the condition is more convincing. On the basis of this hypothesis numerous studies have been conducted into the efficacy of various antidepressants in the treatment of this hypersensitivity. Involutional depressions are more common among women and are found in about 10% of 60-65 year olds. This report claims that combined viloxazine-piracetam is the most appropriate treatment for involutional depression. This approach (200 mg oral viloxazine and 9 g oral piracetam a day) was adopted for 3 months in 33 out patients about 64 years old who were subsequently put on maintenance doses (100 mg viloxazine, 3 g piracetam a day). The various Hamilton scale parameters were assessed as were reaction times to auditory and visual simple stimuli. Result sat the start and end of treatment were then compared. About three quarters of the patients showed improvement in both depression and psycho-organic syndrome symptoms, while total remission or lasting improvement in both pathologies was obtained in about 50%.
 ...
PMID:[Nonpsychotic involutional inhibited depressions and psycho-organic deteriorations: treatment with Viloxazine and piracetam]. 274 75

A total of 289 stroke patients over age 65 were followed-up 5 years post-discharge from in-patient rehabilitation. Predictors of the course following discharge are investigated and geriatric rehabilitation assessed based on data gathered during in-patient rehabilitation as well as follow-up findings. 40% of the patients were alive 5 years post-discharge; the average annual death rate of 14.6% had been three times higher than among a control group. 67% are living in their own home, 21% in a nursing facility, and 12% in a residence for the elderly; only 3 of the surviving patients had to move to a nursing home post discharge. The patients' independence had reduced by an average 5 points on the Barthel index. Negative predictors for survival had been the presence of cardiac disease, Diabetes mellitus, psycho-organic syndrome and depression at discharge. However, as is the case for age as such, these conditions do not affect survivors' functional outcomes. Two thirds of the patients consider their state of health as constant or improved; only one fifth were rated as having a poor quality of life. The data gathered for the follow-up patients show that geriatric stroke rehabilitation is worthwhile.
 ...
PMID:[5 years follow-up study of stroke patients over 65 years of age]. 797 60

Mental morbidity in the elderly comprises mainly affective disorders (manic depressive psychosis) and psycho-organic syndrome, delirium and dementia. Psychiatric disorder occurs with physical disorder or handicap and co-morbidity is the hall-mark of geriatric medicine. The prevalence rate is around 89/1000 population. The decreasing age at onset of depression over successive generations contributed by the 'unstable genes' is discussed. Factors affecting the 'quality ageing' are highlighted. Depression, mania and suicide behaviour in the elderly are detailed. Particular attention is drawn to 'vascular depression' resulting from cerebrovascular lesions affecting the striato-pallido-thalamo-cortico-pathways. Vascular depression is characterised by a low frequency of family history of mental disorder/suicide and anhedonia and increased functional disability. Subsyndomal depression is a fairly common occurrence. Anxiety disorders in the elderly though uncommon need to be recognised. Late-onset schizophrenia and somatic hallucinosis are referred to.
 ...
PMID:Psychiatric morbidity in the aged. 936 69