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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We conducted several tests of the idea that an inclination toward thought suppression is associated with obsessive thinking and emotional reactivity. Initially, we developed a self-report measure of thought suppression through successive factor-analytic procedures and found that it exhibited acceptable internal consistency and temporal stability. This measure, the White Bear Suppression Inventory (WBSI), was found to correlate with measures of obsessional thinking and depressive and anxious affect, to predict signs of clinical obsession among individuals prone toward obsessional thinking, to predict depression among individuals motivated to dislike negative thoughts, and to predict failure of electrodermal responses to habituate among people having emotional thoughts. The WBSI was inversely correlated with repression as assessed by the Repression-Sensitization Scale, and so taps a trait that is quite unlike repression as traditionally conceived.
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PMID:Chronic thought suppression. 786 7

A case is presented of a patient diagnosed with attention deficit disorder, obsessive thinking, anger outbursts, and depression who had a SPECT study prior to treatment and after 3 years of treatment on clomipramine. The follow-up SPECT study showed marked improvement overall in the cerebral perfusion of the brain. At rest marked overactivity was noted in the anterior medial aspects of the frontal lobes, along with "patchy" (increased and decreased) uptake throughout the cortical and subcortical areas of the brain. After treatment for 3 years on clomipramine at 225 mg a day, the follow-up SPECT study revealed a normalization of activity in the anterior medial aspects of the frontal lobes as well as no patchy uptake cortically and subcortically as noted in the study prior to treatment. The clinical usefulness of the SPECT study as it relates to this case is discussed.
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PMID:Three years on clomipramine: before and after brain SPECT study. 924 99

Worry, rumination, and obsessive thinking are theorized to differ on temporal orientation, positive perceived function, degree of intrusiveness, and discordance with one's self-concept. However, prior findings with respect to such differences may be due to method variance of the measures used and/or inclusion of items confounded by diagnostic symptoms. Accurately capturing differences between types of perseverative thought linked to psychopathology and understanding whether such aspects are common across disorders or specific to some may be important to designing effective treatments for them. Two studies are presented detailing the development and validation of the Perseverative Cognitions Questionnaire (PCQ). The PCQ is a 45-item self-report measure that assesses six dimensional characteristics of worry, rumination, and obsessive thinking previously found to discriminate these thought styles: Lack of Controllability, Preparing for the Future, Expecting the Worst, Searching for Causes/Meaning, Dwelling on the Past, and Thinking Discordant with Ideal Self. Factor structure of the PCQ was established using principal components, exploratory factor, and confirmatory factor analyses. PCQ scales exhibited differential convergence with measures of perseverative thought and psychopathology. The PCQ also demonstrated acceptable retest correlations across 1- and 2-week periods, and incremental validity when predicting symptoms of anxiety, depression, and obsessive compulsive disorder.
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PMID:Delineating Characteristics of Maladaptive Repetitive Thought: Development and Preliminary Validation of the Perseverative Cognitions Questionnaire. 2835 81