Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To determine whether gains from exposure therapy are lasting in patients with chronic obsessive compulsive disorder, the authors followed up 34 (85%) of 40 such patients who had been treated 6 years earlier with exposure therapy for 3 or 6 weeks and with clomipramine or placebo for 36 weeks. Severity of obsessive compulsive disorder was assessed by rating the discomfort caused by the time devoted to four target rituals, the Behavioral Avoidance Test, and the Compulsion Checklist. Mood was assessed by the 17-item Hamilton Rating Scale for Depression, the Wakefield Self-Assessment Depression Inventory, and the Anxiety scale. In addition, the patients' general adjustment was assessed. The authors found that the group as a whole remained significantly improved on obsessive compulsive symptoms, work and social adjustment, and depression; however, the group returned to pretreatment levels (slight to moderate) of general anxiety. They found that neither clomipramine nor placebo affected long-term outcome and that the majority of patients who were taking clomipramine or other antidepressants at follow-up were no more improved that those who were not taking antidepressants. Better long-term outcome correlated with more exposure therapy (6 weeks of therapy vs. 3 weeks) and with better compliance with the exposure therapy homework. The best predictor of long-term outcome was improvement at the end of treatment. Subjects who had initially been most depressed were more likely to receive psychotropic medication during follow-up. Initial severity of illness did not preclude benefit from exposure therapy.
 ...
PMID:Six-year follow-up after exposure and clomipramine therapy for obsessive compulsive disorder. 201 46

In the present paper, the results are summarized of MMPI measurements in 210 cases of neurosis. They, by the criteria of Chinese T score, show an increase in the scales 1, 2, 3 and 7 and have an identical rate of 87.5%. Hence, it is reasonable for the scales above to be designated as the coding model of neurosis. In every type of neurosis the scales 1, 2, 3 and 7 have a tendency to increase, but there is a slight difference in their highest point and kurtosis. In depression neurosis, neurasthenia and anxiety neurosis the scale 2 (D) increases dominantly; in hysteria, the scale 3 (HY); in hypochondria, the scale 1 (HS); in phobic and compulsion neurosis, the scale 7. Therefore, MMPI measurements can be useful for clinical classification of neurosis.
 ...
PMID:[Analyzing MMPI examination in patients with neurosis by the criteria of Chinese T score]. 225 3

Experience at University Hospitals of Cleveland with 71 cases of Gardner and Diamond's syndrome of autoerythrocyte sensitization is reviewed. Gardner and Diamond attributed the pathogenesis of the inflammatory bruises typical of this syndrome to sensitization to the stroma of the patients' own erythrocytes, as demonstrated by reproduction of the lesion on intracutaneous injection of erythrocytic stroma. Nearly all the cases my colleagues and I have seen were in adult women, in whom the onset of inflammatory bruising could often be precisely dated, frequently some weeks after an injury or surgical procedure or, more often, severe emotional stress. Bouts of bruising were often preceded by sensations localized to the affected site. Cutaneous responses to the injection of erythrocytes were erratic. The patients described a wide range of both hemorrhagic and nonhemorrhagic complaints, including, among others, severe headaches, paresthesias, repeated syncope, diplopia (sometimes monocular), and "nervousness." Psychiatric studies indicated that patients had overt depression, sexual problems, feelings of hostility, and obsessive-compulsive behavior. The patients had traits that can be described as typical of a hysterical character disorder. Therapy of autoerythrocyte sensitization--that is, psychogenic purpura--has been difficult; in younger individuals, psychiatric therapy has appeared to be beneficial.
 ...
PMID:Psychogenic purpura (autoerythrocyte sensitization): an unsolved dilemma. 248 28

Mandatory testing for AIDS is controversial. Such screening has been suggested for prisoners, immigrants, prostitutes, military personnel, and persons contemplating marriage or pregnancy. Quarantining and even tatooing have also been recommended for persons with AIDS. The advent of mass testing raises the issues of (1) proper allocation of scarce AIDS resources; (2) the need for confidentiality of examination reports; (3) the value of this assessment without the existence of a definitive treatment; (4) the possibility of both false positive and false negative results; and (5) the provision of counseling for people with positive testing. Other concerns involve public health needs versus individual rights, and the confidentiality of the doctor-patient relationship. Past epidemics serve as paradigms for the role of mandatory screening and quarantine in a public health crisis. As testing for AIDS is expanded, anticipate that adverse reactions such as panic, depression, grief, compulsive behavior, and suicide attempts will increase. The physician must provide counsel on such matters as "safe sex" practices, avoidance of needle sharing, and early warning signs of AIDS and ARC.
 ...
PMID:What about mandatory AIDS testing? 272 20

Seven cases of nightmare were treated by simple rehearsal of the nightmare and/or rehearsal with an altered ending, followed by earlier introduction of the ending. One-year follow-up of five patients showed complete relief from nightmares in the four patients who achieved early introduction of a 'masterful' ending, and marked improvement in the patient who could only imagine a neutral ending. All but one of the patients also presented with neurotic symptoms (anxiety, phobias, depression and compulsion/obsession). These were treated by rational discussion and the formulation of positive 'threat-eliminating' statements to be repeated as homework and in times of stress.
 ...
PMID:Therapeutic manipulation of nightmares and the management of neuroses. 286 8

The author examined 60 patients with attack-form schizophrenia whose clinical picture was predominantly characterized by definite compulsions (dromomania, kleptomania, suicidomania, homicidomania, compulsive sexual disturbances, compulsion in relation to eating). Compulsions were most often first manifested at the age of 14 to 30 years. The results have shown that in the majority of cases compulsions developed in the presence of affective states in the form of melancholic, dysphoric, apathetic or adynamic depression, less commonly in the structure of affective delirious syndromes.
 ...
PMID:[Psychopathology and clinical picture of impulsive tendencies during schizophrenia]. 342 83

To assess conduct in Tourette syndrome (TS), 47 controls, 246 TS patients, 17 attention-deficit-disorder (ADD), and 15 ADD patients with minor tics or a family history of TS (ADD 2(0) TS) were compared for the following behaviors: running away from home, lying, stealing, starting fires, vandalism, being in trouble with the law, fighting, shouting at parents or peers, attacking others, lack of respect for adults, short temper, hurting animals, feeling full of hate, being unable to stop fighting, and problems with drugs and alcohol. With the exception of running away from home and being in trouble with the law, TS patients were significantly different from controls in all other behaviors. When the components were combined for a total conduct score, only one (2.1%) of the controls had a score greater than 13, and he had TS. By contrast, 35% of the TS patients had scores greater than 13 (P less than .0005). The correlation coefficient between the total conduct score and ADD score was .48. Although the presence of ADD was an important factor in determining conduct in TS, other factors such as depression and compulsive behavior also played a contributing role. There was little correlation between the total conduct score and the number of tics. It is estimated that among non-economically disadvantaged children, 10%-30% of conduct disorder may be due to the presence of a TS gene.
 ...
PMID:A controlled study of Tourette syndrome. II. Conduct. 347 13

The fear questionnaire (Marks and Mathews) is presented in an original french translation. The questionnaire's validity, sensibility and reliability are studied in four groups: agoraphobia with panic attacks, obsession-compulsion, social phobia and control. The scale has a good empirical validity especially for agoraphobia measurement. However in our study the boundaries between obsession compulsion and social phobia appear questionable. Principal components analysis yields four factors similar to those found by Marks and Mathews: agoraphobia, blood and injury phobia, social phobia, and anxiety-depression (including one panic item).
 ...
PMID:[Validation and factor analysis of a phobia scale. The French version of the Marks-Mathews fear questionnaire]. 358 63

The purpose of this study was to compare the emotional symptoms and physical health of parents whose children had died suddenly in an accident, parents whose children had died following a chronic disease, and nonbereaved parents. Data for this retrospective survey were collected by mailed questionnaires: the Hopkins Symptom Checklist (HSCL), Bereavement Health Assessment Scale, Review of Life Experiences Scale, and a personal-situation questionnaire. Subjects were 30 bereaved parents who had experienced the death of a child following a chronic disease; 31 bereaved parents whose children died in an accident; and 81 nonbereaved parents. Findings indicated significant differences between the bereaved groups and the control group on the total scale score of the HSCL and on the subscales measuring Depression, Anxiety, Somatization, Obsession-Compulsion, and Interpersonal Sensitivity. However, there were no differences on these variables between the two bereaved groups. Bereaved parents with higher concurrent life stresses and parents from a lower socioeconomic background were at higher risk for emotional symptomatology. There were no significant differences among the three groups on the number of physician/nurse visits, number of hospital admissions, number of new or recurrent illnesses, or drug usage. Bereaved parents, however, more frequently reported appetite and sleep problems.
 ...
PMID:Emotional symptoms and physical health in bereaved parents. 384 35

Presented here is a model for the diagnosis and treatment of cocaine dependence. Intrinsic in the understanding of this model is the use of the disease concept of chemical dependence. Within the construct of this model we regard cocaine dependence or "cocainism" as a disease process and part of the spectrum of the disease of chemical dependence. We note that "pure" cocainism is rare and cocaine is usually just another chemical used in the polyaddicted patient. We call cocaine the "Great Precipitator" as it often brings the polyaddicted chemically-dependent person into a crisis that requires a treatment intervention. Cocainism, with its overwhelming compulsion and destruction, often precipitates a crisis in a matter of months from first use. As psychiatrists practicing addictionology, we understand the need to deal with cocainism as a primary disease process rather than a symptom of an underlying psychiatric illness. We deal with cocainism as we deal with alcoholism. While the DSM-III requires withdrawal and tolerance changes to be an essential feature for dependence, we more easily identify the disease of cocainism by its production of intense psychological addiction. Thereby the diagnosis of the disease of cocainism, as with other drugs (including alcohol) in the spectrum of chemical dependence, is characterized by the persistent, uncontrolled, compulsive use of cocaine. This illogical, irrational compulsion with continued, repeated use of cocaine as it destroys the individual's life, is the primary symptom of this disease. In regards to specific considerations, the psychiatric complications of cocainism, which can include cocaine induced psychosis, can persist beyond the intoxication period. We also note the depression that can accompany abstinence from cocaine and often has a protracted course following initial abstinence as well. We advocate the very cautious use of any psychotropic medications after an alloted period of time since we find that many of these additional symptoms seem to dissipate during the treatment process when involved in our suggested setting. In the cases of where it is determined that additional psychiatric illness co-exist with cocaine and chemical dependence such as in "dual diagnosis" patients, we have had that success by treating both illnesses concomitantly and aggressively. The "contract" with the dual diagnosis patient has afforded excellent results in this instance. The treatment modalities most effective in this model include a treatment team with its multidisciplinary and recovering and non-recovering characteristics, and the use of the group process and peer group therapy.(ABSTRACT TRUNCATED AT 400 WORDS)
 ...
PMID:Cocainism--a workable model for recovery. 387 Jul 54


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>