Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The last stages of HIV infection are marked by increasing pain, gastrointestinal discomfort, and depression. These conditions should be treated aggressively with restorative and prophylactic therapies. Patients who are bedridden or are suffering from an inflammatory or infiltrative process may suffer from somatic or visceral pain, which can be treated with analgesics. Patients with chronic pain and a history of narcotic abuse are not likely to develop addictions to opiates, and narcotics can be prescribed. Meanwhile, neuropathic pain, characterized as burning and tingling, is treated with tricyclic antidepressants and antiepileptic drugs. Also, depression, which affects up to 30 percent of HIV-positive patients, should be treated with the selective serotonin reuptake inhibitors. As a patient approaches death, talking with the patient, providing physical contact, and encouraging spiritual reflection can be beneficial. Current hospice care for AIDS patients needs to be improved, and palliation of the HIV disease should be predicated on patient preference, ease of administration, and minimization of side effects.
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PMID:Palliative care and HIV, part II: systemic manifestations and late-stage issues. 1136 57

Our objectives were to compare behaviour problem scores (BPS) for Icelandic adolescents admitted for detoxification treatment for alcohol and narcotic abuse as compared with the general population, in accordance with the Youth Self Report (YSR), and to describe psychosocial functioning and psychiatric comorbidity for the treated adolescents. The case series consisted of 103 adolescents, ages 12-18 years, who completed the YSR at the end of a 10-day stay at the National Hospital of Addiction Medicine. The total BPS tallied from the YSR items was compared with scores for the general population. The psychiatric comorbidity and psychosocial functioning of the case series were assessed through diagnostic interviews in accordance with DSM-IV and ICD-10 criteria. The BPS for the 36 treated girls was significantly higher than for the general population (104 versus 36) and higher than for the 56 treated boys (82 versus 56) with 2 standard deviations above the norm for the population. Three-quarters of the adolescents had psychiatric comorbidity: conduct disorder (44%), depression (28%), or posttraumatic stress disorder (11%). The findings support the discriminative validity of the YSR as part of a structured global assessment of substance-abusing adolescents, in particular to identify the frequently present psychiatric comorbidities.
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PMID:Psychosocial functioning and psychiatric comorbidity among substance-abusing Icelandic adolescents. 1182 6