Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The reliability and validity for use in psycho-geriatric practice of a short and experimenter-rated version of the Zung (Self-rating) Depression Scale, the Zung-12, was studied. The subjects (N = 237) were aged 62 years or older and lived independently, in adapted dwelling, in homes for the aged, or received psychogeriatric daycare in psychogeriatric nursing-homes. It was concluded that the Zung-12 was sufficiently reliable (Cronbachs alpha = 0.85). According to factor analyses the test had high loadings on a depression factor and there were no loadings on a dementia factor. Age did not correlate with depression-scores. In comparison with other living situations the percentage of depressive persons in homes for the aged appeared to be high. Norms in the form of percentile scores were calculated separately for the homes for the aged and the remaining living situations.
 ...
PMID:[The Zung-12: a questionnaire for depression in the elderly]. 144 Jul 60

1. Normal pressure hydrocephalus (NPH) is a rare but potentially treatable form of dementia. Shunting will improve functioning in 40% to 50% of patients. 2. The classic symptoms of NPH are dementia characterized by mild memory impairment and apathy, ataxic gait, and urinary hesitancy or incontinence. 3. The patient with NPH may present with psychiatric symptoms of depression, paranoia, visual hallucinations, irrational hostility, and aggression or mania. 4. Patients with NPH are indifferent about activities of daily living and personal safety and require close supervision.
 ...
PMID:Normal pressure hydrocephalus. A potentially reversible form of dementia. 161 84

The relationship between depression and dementia in Parkinson's disease (PD) has rarely been explored. Using a quantitative EEG (qEEG) parameter, we studied four groups of subjects: PD, demented Alzheimer's type and major depressed patients and normal controls. The qEEG data were compared with those of the Mini-Mental State and the Hamilton Depression Scale. The qEEG pattern was different in the four groups of subjects. Moreover, there was a significant correlation between the qEEG data and the other variables, and, particularly, with the cognitive performances. Our findings demonstrate that the qEEG method of assessment may give valuable data for a better classification of dementia syndromes and for a distinction between dementia and pseudodementia.
 ...
PMID:Quantitative electroencephalography in Parkinson's disease, dementia, depression and normal aging. 162 76

This study examined naming abilities in three groups of older adults with: I) major depression alone, II) major depression with reversible cognitive dysfunction, and III) dementia with depression. Groups I and II differed significantly from dementia patients in total correct responses to a visual-confrontation naming task (Boston Naming Test). Qualitative aspects of naming, specifically types of errors characterizing each patient group, were examined, but no statistically significant differences among groups were observed. The results support the contention that the presence of dysnomia may be useful in discriminating cognitive abnormalities secondary to dementia from cognitive dysfunction associated with depression.
 ...
PMID:Dysnomia in the differential diagnosis of major depression, depression-related cognitive dysfunction, and dementia. 162 65

The Folstein Mini-Mental State Examination (MMSE) and dementia screening measures developed by Benton (temporal orientation, oral word association, and visual reconstruction tasks) were compared for diagnostic efficacy with geriatric inpatients manifesting depression without dementia or mild or moderate dementias complicated by depression. Both instruments showed generally acceptable differentiation between dementia and depression-only cases overall. The MMSE was less sensitive in identifying mild and moderate multi-infarct dementias but showed better specificity than the Benton measures. The degree and type of dementia and the associated risk of classification error were found to be important factors in the choice of screening instruments.
 ...
PMID:Comparison of two cognitive screening measures for efficacy in differentiating dementia from depression in a geriatric inpatient population. 162 79

A battery of neuropsychological tests was examined to establish its value in differentiating mild dementia from depression. The battery was applied to 84 subjects: 31 dementia patients of several etiologies, 31 patients with major depression and 22 volunteers whose age and educational level was similar to that of the patients. The battery consisted of tests for immediate, recent and remote memory, the Mini Mental State examination, a screening test for language disorders, and tests measuring abstraction, calculation, judgement, praxic and gnosic functions. The results showed significant differences among the three groups in all memory tests. Deficits of abstraction, calculation, praxis and language functions were strongly associated with dementia. The epidemiological analysis of efficiency increment, with determination of sensitivity and specificity, showed a highly significant enhancement of efficiency for diagnostic purposes when the results of the tests were combined. These findings suggest that the entire battery of neuropsychological tests should be applied, and their results compared using the efficiency increment procedure, in order to establish a firm differential diagnosis between dementia and depression, and/or to detect the former when it is at a mild early stage.
 ...
PMID:Differential diagnosis between dementia and depression: a study of efficiency increment. 164 8

Previous studies have shown that general practitioners often fail to detect dementia and depression in their elderly patients. The present study aimed to find out how much knowledge general practitioners have of these disorders. The knowledge of 36 general practitioners was assessed and it was found that they had a limited knowledge of the symptoms and signs of dementia and depression. Furthermore, almost 60% of the general practitioners did not know that Alzheimer's disease is the most common dementing disorder.
 ...
PMID:General practitioners' reported knowledge about depression and dementia in elderly patients. 164 7

Providing long-term care for a demented relative profoundly affects caregivers' lives. We assessed changes in depression, immune function, and health in 69 spousal caregivers who had already been caregiving for an average of five years and 69 sociodemographically matched control subjects. Between the initial sample ("intake") and the follow-up data collected an average of 13 months later, caregivers showed decrements relative to controls on three measures of cellular immunity. Caregivers also reported significantly more days of infectious illness, primarily upper respiratory tract infections. Caregivers had a much greater incidence of depressive disorders than controls, with 25% of caregivers meeting syndromal criteria at intake and 32% at follow-up, compared with no cases among controls at intake and 6% at follow-up. Caregivers who reported lower levels of social support at intake and who were most distressed by dementia-related behaviors showed the greatest and most uniformly negative changes in immune function at follow-up.
 ...
PMID:Spousal caregivers of dementia victims: longitudinal changes in immunity and health. 165 78

Biogenic amine neurotransmitters and metabolites as well as choline acetyltransferase activity were quantified in eight brain regions from 37 demented patients, with or without major depression, and 10 controls with no history of dementia or depression. The middle frontal and temporal cortex, prosubiculum and entorhinal cortex of the hippocampus, substantia nigra, thalamus, amygdala, and caudate were examined. Demented patients with major depression exhibited a 10-fold to 20-fold reduction in the level of norepinephrine in the cortex, along with relative preservation of choline acetyltransferase activity in subcortical regions, compared with demented patients who were not depressed. Serotonin levels were reduced in all eight brain regions, but the reduction did not reach statistical significance in any region examined. A para-doxical increase in dopamine levels was observed in the entorhinal cortex of depressed, demented patients, although no consistent pattern of change in the level of this neurotransmitter emerged across brain regions. Our results indicate that the development of major depression in primary dementia is associated with a profile of concurrent neurochemical changes that is largely consistent with existing neurochemical hypotheses of idiopathic affective disorders, and qualitatively distinct from that associated with primary dementia.
 ...
PMID:Neurochemical correlates of major depression in primary dementia. 168 44

The first part of this article addresses the neuropsychiatric aspects of human immunodeficiency virus (HIV) infection in children and adolescents, including developmental delay, depression, and dementia. The specific clinical issues of disclosure of diagnosis and discussion of death with a child are examined. The second part presents aspects of the impact of AIDS on families, approaches to HIV antibody testing, and therapeutic interventions for the family.
 ...
PMID:Psychosocial aspects of AIDS in children and adolescents. 170 86


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>