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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Exercise should be part of everyone's lifestyle, but may be a particularly important part of the treatment of patients with depression and chronic fatigue. It will reliably and consistently decrease feelings of tiredness and despondency, although it is seldom sufficient as a sole treatment intervention for such patients. When initiating an exercise program, a baseline assessment should be followed by an exercise prescription and an appropriate degree of patient education about exercise physiology. This should be followed, in addition to other treatment interventions, by regular follow-up visits to make appropriate adjustments; provide encouragement and motivation to continue; monitor weight, body fat, and nutrition; and assess the effectiveness of the program on the underlying problem.
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PMID:Exercise. Practical treatment for the patient with depression and chronic fatigue. 187 13

Among people with spinal cord injuries, death from suicide is two to six times more prevalent than in the general population. To determine if individual characteristics and behaviors present during rehabilitation can identify high-risk individuals, records of 5,200 spinal cord injured patients admitted to the Rocky Mountain Regional Spinal Injury System were reviewed. Of 489 deaths, 9% were due to suicide. They were compared with a control group of equal size, matched on age, gender, and injury level. The two groups differed significantly on postinjury despondency; expressions of shame, apathy, and hopelessness; and preinjury family disruption (p less than .01). They also differed on alcohol abuse, active involvement in the injury, preinjury depression or despondency, destructive behavior, and one aspect of etiology (p less than .05). Discriminant analysis yielded a predictive model that correctly classified 81% of the suicide group and 79% of the control group. Many of the demographic predictors identified in this study are similar to those reported in the scientific literature. However, when combined with specific behavioral characteristics manifested during rehabilitation, they comprise an array of variables that permits development of a clinical model for predicting suicide among persons with spinal cord injuries.
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PMID:Behavioral and demographic predictors of suicide after traumatic spinal cord injury. 205 21

Depression is a universal experience, which affects approximately 15 percent of the population at any one time. Depression can be conceptualized as occurring on a continuum from first-level transitory to middle-level to severe-level depression. It involves an alteration in mood characterized by feelings of sadness and loss of interest or pleasure in all, or almost all, the client's usual activities and pastimes. Alterations in thought, motor activity, somatic sensations, and social relationships are also associated with depression. Severe depression can also be associated with delusional thought patterns. Finally, depression can vary in length of duration; it can be transitory and short-lived or ongoing and chronic. Assessment of individual, family, and community factors is important in identifying the factors relevant to planning individualized care for the depressed client and his/her family. Nursing diagnosis includes problems of low self-esteem, feelings of despondency, suicidal thoughts/impulses, and vegetative signs of depression. Nursing interventions are guided by certain principles, and are best evaluated when expected client behaviors have been projected. In conclusion, the overwhelming majority of those who experience depression recover and achieve a higher level of wellness than before the depression; that is, if they use the opportunity to develop a more realistic view of self, others, and their world relationships.
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PMID:Signs and symptoms of depression and principles of nursing intervention. 350 69

Israeli Prime Minister Menachem Begin resigned shortly after the death of his wife. A classic portrait of the grieving widower, his despondency did not surprise mental health professionals. One psychiatrist explained that "Women take bereavement better than men because the widow keeps her domain" while the widower tends to become disoriented. This article examines the perception that men, specifically aging men, are more emotionally distressed than aging women by their spouse's death. A literature review reveals little evidence from behavioral or psychological studies to support the perception, along with mixed evidence of higher male mortality rates in some age groups. Data from a random probability community mental health survey are presented. Prevalence rates for the bereaved are significantly greater than are married rates for only one of the five measures of mental disorders. Widows report significantly more overall distress and depression, but these differences disappear when gender is examined, along with other sociodemographic variables in regression analyses. Clearly, these findings and those from studies of elders, do not support the perception that aging widowers experience more emotional problems during bereavement than do aging widows. Perceptions and mental health policies should be revised to reflect the reality of more similarities than differences among aging widows and widowers.
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PMID:Aging widows and widowers: are there mental health differences? 355 39

Although previous studies have reported that all patients with spinal cord injuries experience depression, they have not distinguished between despondency and depressive disorder. Of 30 patients with spinal cord lesions and depressive disorders diagnosed using the Schedule for Affective Disorders and Schizophrenia and the Research Diagnostic Criteria (RDC). 15 patients had RDC diagnoses before or after their injury. A depressive disorder developed in nine after injury. Eight depressive disorders developed within a month of the injury. Postinjury depressive disorders were more common in patients with complete spinal cord lesions but were divided equally between paraplegics and quadriplegics. Only one patient received antidepressants. The remainder recovered without treatment other than the rehabilitation program. The accident causing the injury seemed related to a psychiatric disorder before injury in six patients (four alcoholics and two hypomanics) and to drinking before the accident in 15 patients.
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PMID:Psychiatric disorders in patients with spinal cord injuries. 731 82

This paper reviews research methods for detecting and assessing depressive symptoms in peri-menopausal women. The paper is written from the standpoint of clinical psychiatrists and clinical psychologists. Problems of method arise in two main areas: (i) the selection of population samples; (ii) the choice of methods for defining, detecting and measuring depression. An important distinction should be made between depressed mood and depressive disorder. Depressed mood is familiar sadness, low spirits, or despondency. Depressive disorder is a syndrome which is much more serious. The failure to make this distinction can detract from research findings. Standardised measures should always be used. These measures may be either self-rated or interviewer-rated. It is emphasised that the choice of these measures should be based on four characteristics: criterion overlap, sensitivity, test-retest reliability, and utility. The scales already available can be valuable provided that they are chosen carefully and with particular regard to these four qualities.
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PMID:The assessment of depression in peri-menopausal women. 964 15

Depression is a common health problem in the adolescent population. The Reynolds Adolescent Depression Scale (RADS) is used to measure depression in clinical and community adolescent samples. Although there is available evidence for the reliability and validity of the RADS, there is insufficient documentation of its factor structure. This study examined the factor structure of the RADS in adolescent boys and girls (m-144). Internal consistency reliability ranged from .91 to .94 based on grade level, and was .91 for boys and .93 for girls. Factor analysis resulted in a 5-factor solution. Interpretation of factors were as follows: (a) Factor I--generalized demoralization; (b) Factor II--despondency and worry; (c) Factor III--externalized somatocism; (d) Factor IV--anhedonia; and, (e) Factor V--self-worth.
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PMID:Factor structure of the Reynolds Adolescent Depression Scale in a sample of school-based adolescents. 1102 64

Akita Prefecture, Japan, has consistently recorded the highest level of suicide rates in all of Japan. In this study, we attempted to determine whether genetic differences between suicide victims and the normal population in Akita exist. We also researched the geographical differences in polymorphisms of the genes between people living in Akita Prefecture and those living in other prefectures with lower suicide rates as recorded in previously-published studies. Specifically, we investigated two serotonin-related genes including three substitutions connected to human emotional states such as despondency and depression: the tryptophan hydroxylase (TPH) gene (A779C and A218C in the intron) and the serotonin1A (5-HT1A) receptor gene (Pro 16Leu in the cording region). 134 suicide victims and 325 healthy volunteers were examined. For this process, we used two analytical procedures: (1) polymerase chain reaction (PCR) followed by single-strand conformational polymorphisms analysis for the A779C of TPH and the 5-HT1A receptor genes and (2) PCR followed by restriction fragment length polymorphism analysis for the A218C of TPH gene. No significant differences of the genotypes and the allele frequencies between the suicide samples and those of the healthy controls were discerned. Moreover, the genotype distributions of the TPH and 5-HT1A receptor genes were compared between Akita Prefecture and other prefectures, but no significant differences were found. In conclusion, no significant relation could be established statistically concerning the serotonin related genes between the suicide samples and control samples in Akita.
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PMID:Polymorphisms of the tryptophan hydroxylase gene and serotonin 1A receptor gene in suicide victims among Japanese. 1499 6

Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism, anhedonia and sadness where these symptoms severely disrupt and adversely affect the person's life, sometimes to such an extent that suicide is attempted or results. Antidepressant drugs are not always effective and some have been accused of causing an increased number of suicides particularly in young people. Magnesium deficiency is well known to produce neuropathologies. Only 16% of the magnesium found in whole wheat remains in refined flour, and magnesium has been removed from most drinking water supplies, setting a stage for human magnesium deficiency. Magnesium ions regulate calcium ion flow in neuronal calcium channels, helping to regulate neuronal nitric oxide production. In magnesium deficiency, neuronal requirements for magnesium may not be met, causing neuronal damage which could manifest as depression. Magnesium treatment is hypothesized to be effective in treating major depression resulting from intraneuronal magnesium deficits. These magnesium ion neuronal deficits may be induced by stress hormones, excessive dietary calcium as well as dietary deficiencies of magnesium. Case histories are presented showing rapid recovery (less than 7 days) from major depression using 125-300 mg of magnesium (as glycinate and taurinate) with each meal and at bedtime. Magnesium was found usually effective for treatment of depression in general use. Related and accompanying mental illnesses in these case histories including traumatic brain injury, headache, suicidal ideation, anxiety, irritability, insomnia, postpartum depression, cocaine, alcohol and tobacco abuse, hypersensitivity to calcium, short-term memory loss and IQ loss were also benefited. Dietary deficiencies of magnesium, coupled with excess calcium and stress may cause many cases of other related symptoms including agitation, anxiety, irritability, confusion, asthenia, sleeplessness, headache, delirium, hallucinations and hyperexcitability, with each of these having been previously documented. The possibility that magnesium deficiency is the cause of most major depression and related mental health problems including IQ loss and addiction is enormously important to public health and is recommended for immediate further study. Fortifying refined grain and drinking water with biologically available magnesium to pre-twentieth century levels is recommended.
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PMID:Rapid recovery from major depression using magnesium treatment. 1654 86

The aim of the study was to investigate 'blues' during the first week postpartum in new mothers and fathers and to compare different instruments for measuring blues, as well as their ability to predict depressive symptoms at 2 months. Parents were informed while at the maternity clinic about the study and asked to independently answer questions for 5 days during the first week on the Blues Questionnaire, a VAS questionnaire and on the Edinburgh Postnatal Depression Scale (EPDS) at 1 week and 2 months. Of the parents who initially agreed to participate in the study 171 (38%) of the mothers and 133 (31%) of the fathers returned all questionnaires completely filled-out after the first week, and of these, 155 mothers and 113 fathers also completed the EPDS at 2 months. The results showed that mothers experienced more blues than fathers, and that mothers' blues peaked on day 3, while fathers' peaked on day 1 after the delivery-day. The Blues Questionnaire and the VAS subscale 'depressed mood' identified more women as having blues (64% and 52%, respectively) during the first week over the EPDS (24%), but the EPDS identified women with the highest scores on the Blues Questionnaire. At 2 months, 19 (12%) of the mothers, and one father scored 10 or more on the EPDS. All these women, except for one, had experienced severe blues according to the Blues Questionnaire, the first week. Regression analyses showed that the Blues Questionnaire subscale 'depression' was the best predictor for a high EPDS score at 2 months in mothers, while the subscales 'primary blues', 'hypersensitivity' and 'despondency' best predicted depressive symptoms in fathers. Our results indicate that the EPDS could be a valuable instrument to measure 'blues', as EPDS seemed to indicate women with the highest risk for depressive symptoms.
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PMID:Comparisons of different instruments to measure blues and to predict depressive symptoms 2 months postpartum: a study of new mothers and fathers. 1848 88


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