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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The conditioning problems of suicidal acts of aged people were described by demonstrating the results of investigations in 125 patients (over 65 years). The control group consisted of 3004 suicidal patients below 65 years. Depression has been the prevailing psychiatric diagnosis (50% in contrast to 33% in the control group). 24% of the patients alleged conflicts with partners or other relatives as a motivation for the suicidal act. Fear of somatic illness or social isolation follows next. It is remarkable that vocational or economical conflicts were not mentioned. At last prevention problems were discussed. The need for modifying the attitude toward the aged was stressed.
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PMID:[Causes, motivations and tendencies of suicidal acts in old age (author's transl)]. 2 35

The relationship between diagnosis and abnormally high fasting blood sugar levels was reviewed for 4,994 patients in a mental hygiene clinic. Fifty-four patients exceeded the criterion level of fasting blood sugar abnormality, FBS greater than or equal to 145 mg%. There was no evidence of relationship between psychiatric diagnosis and the presence of an abnormally high fasting blood sugar level. This held true for the diagnosis of depression despite observations made elsewhere that a significant association exists between the depressions and diabetes.
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PMID:Relationship between high fasting blood sugar and depression in a mental hygiene clinic population. 42 99

Confidence in the assignment of lifetime psychiatric diagnosis is of great importance to genetic studies of psychiatric illness. To establish the credibility of a lifetime psychiatric history obtained via a structured interview, two paradigms were constructed to estimate reproducibility of the interview recording process. The first paradigm, simultaneous coding, was used to test comparability of four interviewers independently coding an interview form. Low variance/high reliability was demonstrated. The second paradigm, test-retest, provided for each subject to be interviewed twice, with a mean interim time of 6.7 months (SEM = .39). This paradigm demonstrated high reproducibility of psychiatric diagnosis over time. The overall k value for measurement of diagnostic agreement was .79. Only the diagnostic category of minor depression seemed to evade reliability. It was shown across both paradigms that an interviewer need not be blind (naive to previously held diagnosis) to obtain an unbiased interview. However, it is still recommended that the diagnosis of each interview should be determined by an independent diagnostician.
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PMID:Blindness and reliability in lifetime psychiatric diagnosis. 43 12

The evidence for disturbances of tryptophan and 5-hydroxytryptamine in depression and for various mechanisms by which such disturbances could occur is discussed. Two recent relevant studies in the author's laboratory are described: a) non-esterified fatty acid and total and free tryptophan were determined in plasmas of psychiatric patients unselected with respect to psychiatric diagnosis before and after a stress situation. Retarded patients had significantly low total and free tryptophan values which correlated negatively with agitation. Total tryptophan fell significantly after stress in the non-retarded subjects. The only biochemical abnormality significantly associated with a diagnosis of primary depression was the rise of plasma non-esterified fatty acid after stress. Thus tryptophan abnormalities were associated more with psychiatric rating scores than with diagnoses. b) Determinations on plasma and lumbar and ventricular CSF from psychiatric patients undergoing psychosurgery indicate that low plasma free tryptophan concentrations are associated with decreased 5HT turnover in the central nervous system.
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PMID:Study of disturbed tryptophan metabolism in depressive illness. 44 10

Non-esterified fatty acid and total and free tryptophan were determined in the plasma of psychiatric patients unselected with respect to psychiatric diagnosis and in the plasma of normal subjects before and after physiological and psychiatric tests. Retarded patients had significantly low total and free tryptophan values which correlated negatively with agitation. Total tryptophan fell significantly after testing in the non-retarded subjects. The only biochemical abnormality significantly associated with a diagnosis of primary depression was the rise of plasma non-esterified fatty acid after testing. Thus, tryptophan abnormalities were associated more with psychiatric rating scores than with diagnoses.
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PMID:Tryptophan disposition in psychiatric patients before and after stress. 48 68

Functional overlay is not a recognized psychiatric diagnosis. Evaluating functional overlay and differentiating between this concept and organic conditions is important in medicolegal areas in which financial values are placed on pain and disability. Functional overlay is not malingering: the former is based on preconscious or unconscious mechanisms, the latter is consciously induced. In considering psychologic reactions to pain and disability, a gradient of simulation, malingering, symptom exaggeration, overvaluation, functional overlay and hysteria is useful. The dynamics of overlay are a combination of anxiety from body-image distortion and depression from decreased efficiency of the body, as well as the resulting psychosocial disruption in a patient's life.
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PMID:Functional overlay: an illegitimate diagnosis? 51 98

At least one psychiatric diagnosis was made for 205 of 220 children whose psychiatric evaluation had been requested by the medical service. Only 78 of 242 psychiatric diagnoses given the 205 patients were reflected correctly in the medical discharge diagnoses. In addition, seven of fifteen patients considered to be "normal" by the consulting psychiatrist had a psychiatric or mixed medical-psychiatric diagnoses included in the discharge diagnoses. Psychophysiological disorders, psychoses and special symptom diagnoses were likely to be correctly reflected in the discharge diagnoses, while depression and adjustment reaction were not. Possible reasons why the psychiatrist's diagnostic opinion is not correctly reflected in the discharge diagnosis in over one-half of the referrals are discussed. Pediatricians may be reluctant to label their patients "neurotic" for life, or may consider the problem transient-that is, only a "passing phase". But these theories are discounted by the fact that seven patients considered to be emotionally normal when assessed by the psychiatrist were discharged with a psychiatric or mixed medical-psychiatric diagnosis.
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PMID:Pediatric referrals to psychiatry: III. Is the psychiatrist's opinion heard? 64 73

During a six-month period, physical disorder was found among 50 per cent of the 133 patients at a day hospital. Few of these cases (5) had organic brain syndromes. Among the remainder (62) physical disorder was not associated with sex, formal psychiatric diagnosis or time of referral to the hospital; of those 33 patients with a neurological disorder, one-third had previously been diagnosed to be hysterical. For this 'hysterical' group, however, associations with folate deficiency, organic brain disease, and depression were noted. The need is demonstrated for routine investigations among day hospital patients with particular attention for those with atypical features.
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PMID:Physical disorder among day hospital patients. 66 4

A 36-year-old pilot took his plane on a brief, unauthorized flight that ended in a high-speed vertical crash next to the runway. A retrospective "psychological autopsy" yielded strong presumptive evidence of an unrecognized depression in a man with manipulative and mildly antisocial characteristics. His withdrawal from his usual patterns of behavior was, instead, regarded as a desirable return to "normal" behavior. This case report includes comments on the role of the psychological autopsy in aircraft accident investigation, anniversary reactions, the use of psychiatric diagnosis to support the agreed-upon decision on the desired disposition, some aspects of subintentional suicidal behavior, a brief review of the literature on suicide by aircraft, and consideration of the role of the flight surgeon in preventing such occurrences through early recognition of depression.
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PMID:Suicide by aircraft: a case report. 88 Jan 84

It has been mentioned that herpes simplex antibodies are increased in depressed patients. In the present study, serums from 21 patients with reactive depressions, nine with psychotic depression, 33 schizophrenic and 15 normal controls were studied, and herpes simplex antibodies were measured. Neither was statistically significant difference found between any of the groups nor could antibody titres be correlated with severity of depression measured by a psychiatric rating scale. The authors review the pertinent literature, and state that although antibody tires do not correlated with psychiatric diagnosis, there still exists the possibility that latent brain viral infections might trigger depressive episodes in some cases.
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PMID:[Depression and Herpex simplex infections]. 125 8


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