Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors found that in a sample of 26 severely depressed hospitalized patients, 5 patients with low depression and psychasthenia profiles on the Minnesota Multiphasic Personality Inventory did not show an antidepressant response to lithium carbonate. Seventeen of 21 depressed patients with high depression and psychasthenia profiles did respond to the antidepressant effects of the drug. They tentatively conclue that by using the MMPI it is possible to delineate a subgroup of depressed patients who are refractory to lithium carbonate therapy.
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PMID:MMPI delineation of a subgroup of depressed patients refractory to lithium carbonate therapy. 23 49

A proportion of postcoronary patients seen 16 to 18 months after infarction are seriously depressed (high D score on Minnesota Multiphasic Personality Inventory). A follow-up of 44 such depressed patients showed a significant (p less than 0.001) decrease of standardized D scores, from 80 to 72 units over 4 years of exercise-based rehabilitation. There were associated decreases in scores for hysteria, hypochondriasis, and psychasthenia. A decrease of D score was associated with exercise compliance. An increase of D score was associated with a significant (p less than 0.05) worsening of ST segmental sagging, suggesting that progression of the disease process had contributed to the increase of depression. All of the patients had high (feminine) scores on the masculinity/femininity scale of the MMPI test. This finding was unrelated to the daily running distance or medication; it could represent a "feminine" personality, or be a typical response in a well-educated white collar group. Evidence of successful group interaction may be indicated by reduction in scores for social introversion and schizophrenic traits.
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PMID:Depression following myocardial infarction: the effects of distance running. 27 Sep 8

The author attempted to determine whether the Minnesota Multiphasic Personality Inventory (MMPI) would be sensitive to a symptom pattern unique to lithium-responsive patients regardless of diagnosis. Statistical analyses of the MMPI scores of lithium responders, lithium nonresponders, and a group of patients receiving other psychotropic drugs revealed that the depression, psychasthenia, mania, and social introversion scale scores significantly differentiated the lithium response and lithium nonresponse groups. No strong indications of significant difference were found between the MMPI scale scores of the lithium nonresponse and psychotropic groups. The results suggest that there is a lithium-responsive syndrome that exhibits a distinctive symptom pattern regardless of its varying phenomenological features in different individuals.
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PMID:The delineation of an MMPI symptom pattern unique to lithium responders. 42 45

The MMPI was administered to 209 obese women and 72 obese men before onset of a weight reduction regime. Obese subjects differ in a variety of MMPI-standard-scales from the standard population as well as from a control group of healthy women: 1. Scales Hypochondriasis (Hs) and Hysteria (Hy) have significant higher values for the obese. This somatic impairment grows in the group of obese women with increasing age and obesity. In men, scale Hs corresponds to the degree of overweight but the youngest male age group (up to 19 years) has a Hs-peak as well as men above 35 years of age. 2. Higher than normal values for obese men and women in scales Depression (D) and Psychasthenia (Pt) in the obese point towards emotional upset. 3. Obesity does not decrease Hypomania (Ma) values for men or women; to the contrary: obese men felt more active than the standard population. With growing age women had a decrease in Ma-values.
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PMID:[Psychological problems in obesity (author's transl)]. 84 Jan 40

The usefulness of combined elevation of the Depression and Psychasthenia scales of the MMPI as a predictor of psychological help-seeking was investigated for two classes at a small liberal arts college for men. Counseling service use rates during the 4 years of college for all students who scored at or above T = 60 on both MMPI scales (N = 83) were compared with rates for all other students (N = 269). Students in the high Depression-Psychasthenia group were significantly more likely to seek counseling during their freshman years than were other students (p less than .05). Among counselees the high MMPI group also made significantly more visits to the service (p less than .05). Application of a Bayesian rule disclosed that the MMPI measure would have improved decision accuracy only with respect to the prediction that a student would come in for counseling at some time during college. In this population, the MMPI measure is both a valid and a useful predictor.
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PMID:Prediction of help-seeking with the MMPI: the problem of base rates. 92 86

Subjects with a primary complaint of insomnia (N = 124) were evaluated with Minnesota Multiphasic Personality Inventories (MMPIs). A high percentage of subjects (85%) had one or more MMPI scales elevated to a pathological degree. The scales most elevated were, in order. 2 (depression), 7 (psychasthenia), and 3 (conversion hysteria). A striking finding was the preponderance of depression. This was indicated by the frequency in which scale 2 was elevated above 70, the frequency in which this this scale had the highest elevation, and the frequency of MMPI code types that included scale 2. Four common MMPI code types representing various types of depression were noted, indicating considerable homogeneity for code types in this sample. The predominant personality styles in this sample were characterized by the internalization of psychological distrubances rather than by acting out or aggression. We propose that this internalization produces a state of constant emotional arousal and resultant physiological activation and that this process is a psychophysiological mechansim underlyling insomnia.
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PMID:Personality patterns in insomnia. Theoretical implications. 96 95

This study compared repeat gonorrhea patients with nonrepeat patients and control patients not having venereal disease. Focus was given to current intellectual and personality attributes as well as a broad spectrum of background factors in social, familial, educational, and sexual history. One-tailed t-tests were computed on the myriad permutations of patient group and the multiple derived scores from the personality and intellectual assessments. The results show no significant differences between the patients having their first infection of VD and the patients with repeat VD; however, when these 2 groups are pooled and compared with the controls, the VD patients are significantly higher on the depression, schizophrenia, psychasthenia, hysteria, and psychopathic scales. A similar pattern exists on reasoning ability and internal versus external locus of control. The VD patients are seen to perceive themselves as much more externally controlled than do the controls. It is concluded that the VD patients might profit from psychologic treatment; such treatment resources might aid not only in the control of repeat infections but in the general social integration of the patients.
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PMID:Sociopsychiatric characteristic of clinic patrons with repeat gonorrhea infections. 101 Jul 64

The Minnesota Multiphasic Personality Inventory was completed by 101 patients 16 to 18 months after a proved myocardial infarction. The data suggested a bimodal distribution of patients. One class of patients had a relatively "normal" personality score apart from a tendency to hypomania. The second class had severe depression, with associated hysteria, hypochondriasis and psychasthenia. The severely depressed patients were older, with a greater tendency to hypertension and angina, and a tendency to smaller gains in aerobic power despite an equal intensity of endurance training. The distinction between "normal" and "depressed" postinfarction patients seems of some clinical importance, for the two classes of patients require opposite supportive techniques--restraint and encouragement, respectively.
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PMID:Depression after myocardial infarction. 114 70

27 women with rheumatoid arthritis had elevated depression and social introversion scores in the Minnesota multiple phasic personality inventory (MMPI) tests, whereas their somatic activity appeared reduced. Age of the patient at time of investigation apparently had no influence on the degree of psychological changes, but was reflected in an increased social introversion. Most important for the degree of psychological impairment was the height of the ARA index, which correlated positively with the neurotic triad as well as the psychasthenia scale in the MMPI. An elevation of the neurotic triad is common in many somatic disease. Patients with rheumatoid arthritis had an additional, introversion and depression, and decreased somatic activity.
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PMID:[Psychological tests of patients with chronic rheumatoid arthritis(author's transl)]. 115 93

Tianeptine is an effective antidepressant with original neurochemical properties. Tianeptine increases the serotonin (5-HT) reuptake after acute and chronic treatment. The efficacy of tianeptine (T) versus placebo (P) was evaluated in the treatment of psychasthenia, because of the role of 5-HT in obsessive-compulsive disorders, the last state of psychasthenia in term of severity. Patients were recruited using the psychasthenia scale; then, their MADRS scores limited those who turned out to the depression. Mean inclusion MADRS scores where 12 (T) and 11.8 (P). Tianeptine is an effective treatment for patients suffering from psychasthenia. Tianeptine is more effective than placebo in global score and in sub-scores (asthenia and somatic symptoms) of the psychasthenia scale. In spite of weak inclusion scores in MADRS, patients taking tianeptine also showed significant improvement, greater than with placebo. The percentage of patients with a reduction equal to or greater than 50% of their MADRS score was significantly more important in tianeptine group. These results could be the illustration of the decrease in associated depressive symptoms or the result of an improvement of symptoms common to MADRS and psychasthenia scales. The same favorable results were obtained in symptoms of anxiety scored by HARS. In term of safety, tianeptine is equivalent to a placebo if we consider somatic complaints expressed by the patients, global improvement evaluated by the patient and the investigator, weight and blood pressure. Interruption of treatment for side-effects concerns the placebo group only (3 versus 0). This excellent safety is particularly well-adapted to the treatment of these out-patients.
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PMID:[Efficacy of tianeptine in the treatment of psychasthenia. A study versus placebo]. 134 Aug 7


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