Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An 11-year-old girl developed a subacute illness characterized by fever, malaise, depression, and meningoencephalitis. The etiology remained elusive until her agglutinin titer against Brucella abortus rose from 1:20 to 1:320. Brucellosis is an uncommon illness in children, an neurological involvement has been described in only ten cases. Brucella meningoencephalitis is characterized by a lymphocytic pleocytosis and elevated protein in the cerebrospinal fluid. Patients respond well to specific therapy; it is important, therefore, to consider the diagnosis of brucellosis in patients with subacute meningitis of unexplained etiology.
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PMID:Brucella meningoencephalitis in childhood. 680 35

The acute intraperitoneal toxicity of ochratoxin A (OA) for adult female Swiss mice is presented. The seven-day LD(50) was calculated to be 48 +/- 3.2 mg/kg. Daily intraperitoneal administrations of 10 mg OA/kg resulted in 50% mortality by the tenth day of injection. Clinical symptoms included depression, huddling, roughened hair coats, humped backs and reduced weight gains. Mice injected intraperitoneally daily for 50 days with 5 mg OA/kg had a significantly (P<0.01) depressed antibody response to killed Brucella abortus. In contrast, oral administrations of OA at 4 ppm in feed for 50 days did not depress titre levels. Ochratoxin A also significantly (P<0.01 intraperitoneal; P<0.05 oral administrations) reduced body weight gain over the period of the trials. Neither oral nor intraperitoneal administration of OA for 50 days affected the response of mice to sheep red blood cells although both the number of antibody-forming cells and the number of cells per spleen were significantly lowered (P<0.01) by cyclophosphamide. Both spleen and body weights were significantly lowered (P<0.05) in the groups given OA. There was a significant depression of blast transformation (P<0.01) in mice treated intraperitoneally with either OA or cyclophosphamide and stimulated with concanavalin A; oral administration of OA did not depress blast transformation. It would appear that lower levels of exposure, e.g. 4 ppm OA in feed, do not cause depression of the immune response of mice. The depressive effect seen at much higher levels may be a result of a nonselective toxic effect.
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PMID:The effects of ochratoxin A on the immune response of Swiss mice. 680 72

The immunodepressive effect of a single, carcinogenic dose of dimethylnitrosamine was tested in a potent model of renal cancer induction using two antigens which differ in their cellular processing. Responsiveness to sheep red blood cells (SRBC), an antigen requiring the collaboration of both thymus-dependent (T) and thymus-independent (B) lymphocytes was determined by a plaque-forming assay; antibody production to Brucella abortus antigen, a thymus-independent antigen was measured in an agglutination test. The results suggested that DMN exerted little or no effect on B lymphocytes in the anti-SRBC antibody response. This effect commenced immediately following the carcinogenic insult from 24 h, with a degree of depression for the first 10 days equivalent to antilymphocyte globulin in terms of numbers of anti-SRBC antibody-forming cells. From 2 weeks there was gradual recovery with full restoration of normal responsiveness at 8 weeks. During the ensuing period of emergence of neoplastic foci in the kidney, and with the progression of such foci to tumors of macroscopic dimensions, there was no accompanying depression of antibody response. The differential effect was discussed in terms of selectivity of action, and lymphocyte subsets.
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PMID:Effect of single carcinogenic dose of dimethylnitrosamine on antibody responses in the rat. 700 60

A high frequency of occurrence of a wasting disease, unthriftiness, and retarded growth was observed in a group of inbred Weimaraner dogs. Affected pups had a small thymus gland, with a marked absence of thymic cortex. A litter of eight pups from a sire and dam that were known to have produced affected offspring was chosen for further study. The pups had normal concentrations of WBC and gamma-globulins and were able to produce antibody in response to Brucella abortus. Two pups in the litter developed a wasting syndrome and responded well to therapy with thymosin fraction 5. One pup that survived the wasting syndrome had a significant (P < 0.05) depression of its lymphocyte blastogenic response to phytohemagglutinin compared with its surviving littermates. Pups from this litter also lacked a normal increase in plasma growth hormone concentration after the injection of clonidine HCl. These pups had concurrent abnormalities of the thymus-dependent immune function and in growth hormone metabolism. The syndrome in these pups has some features in common with the syndrome in the Ames or Snell-Bagg strains of immunodeficient dwarf mice.
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PMID:Thymic abnormalities and growth hormone deficiency in dogs. 744 21

Ten Newcastle disease virus (NDV) and 10 NDV and infectious bronchitis virus (IBV) combination vaccines (NDV/IBV) were evaluated for their effect on the head-associated lymphoid tissue (HALT) of 2-wk-old chicks. After vaccination, the chicks were subjected to an in vivo assay that measures the ability of the gland of Harder (GH) to respond to killed Brucella abortus antigen given in the eye by titering B. abortus antibodies in the tears. Following this, several sites in the HALT and trachea were examined histologically and scored for microscopic changes. The results indicated that three of the NDV/IBV combination vaccines (one BI/Mass&Conn and two LaSota/Mass&Conn) interfered with the GH response to killed B. abortus, whereas none of the NDV vaccines did Histologically, several changes were noted in the vaccinated chicks; however, no changes in the GH were observed that could explain microscopically the GH depression. With the IBV-only vaccines reported earlier (16), and the NDV-only and NDV/IBV combination vaccines reported here, a total of 36 vaccines have been evaluated using the same testing protocol. The conclusions of these combined studies suggest that several of the modified live virus vaccines containing IBV, either alone or in combination with NDV, interfere with the ability of the GH/HALT to respond to antigenic stimulation.
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PMID:Effects of Newcastle disease vaccines and Newcastle disease/infectious bronchitis combination vaccines on the head-associated lymphoid tissues of the chicken. 920 6

Broiler breeder hens were fed diets amended with 0 and 10 mg/kg (Trial 1) or 0, 0.2, 1, or 5 mg/kg (Trial 2) of aflatoxin (AF). Fertile eggs collected during 14 d of AF feeding were examined for AF residues. Various immunological endpoints were examined in chicks hatched from these eggs. Eggs collected at 7 d of AF feeding (Trial 1) had 0.15 to 0.48 ng/g of AFB1 and 0.22 to 0.51 ng/g of aflatoxicol, whereas eggs collected at 14 d of AF feeding had 0.05 to 0.60 ng of AFB1/g and 0.19 to 1.20 ng of aflatoxicol/g. In both trials, AF dietary exposure resulted in embryonic mortality and reduction in hatchability compared to controls. The AF progeny chicks in Trial 2 had total anti-SRBC antibodies similar to the controls during the primary antibody response. However, at 5 and 7 d after secondary SRBC injection, the antibody levels in the 1 and 5 mg/kg AF groups were lower than those of controls. Depression in anti-Brucella abortus antibodies occurred only in chicks from the 5 mg/kg AF group. Furthermore, phagocytosis of SRBC and reactive oxygen intermediate production by macrophages from AF progeny chicks were reduced as compared with the control chicks. The findings of this study imply that the progeny chicks from hens consuming a AF-amended diet may be increasingly susceptible to disease owing to suppression of humoral and cellular immunity.
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PMID:Dietary exposure of broiler breeders to aflatoxin results in immune dysfunction in progeny chicks. 962 28

The purposes of this study were to study the prevalence and incidence of depression in elderly Thais. A field survey study was implemented. The sample consisted of 1,713 elderly people in 35 communities from 4 districts surrounding Siriraj Hospital Bangkok Noi, Bangkok Yai, Taling Chun and Bang Plud. These areas are the peripheral part of Bangkok and most of them have extended family. The Thai Geriatric Depression Scale (TGDS) and the Thai Mini Mental State Examination (TMSE) were used as screening tests, for data collection. The prevalence of depression was 12.78 per cent, of which 8.23 per cent had only depressive symptomatology (male 5.43%, female 9.63%) while 4.55 per cent had both depression and cognitive impairment (male 2.8%, female 5.54%). The point incidence (one year) of depression was 7.27 (male 1.58%, female 5.68%). The major contributing factors in depression were financial, poor family relationships and physical illness. The prevention and management of these factors may bring about a better quality of life for the elderly in Thailand.
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PMID:Prevalence and incidence of depression in the Thai elderly. 1218 82

The purposes of this study were to develop an effective manual for the early self detection of depression in the Thai elderly, to detect the comorbidity of depression (pattern of drug and alcohol abuse, suicidal idea) and to ascertain the quality of life. A quasi experimental field research methodology (Randomized Control Group Pretest-Posttest Design) was implemented. The sample consisted of 1,390 elderly people in 35 communities from 4 districts surrounding Siriraj Hospital-Bangkok Noi, Bangkok Yai, Taling Chan and Bang Phlat. These areas are the peripheral parts of Bangkok and most of them have extended families. The result showed that: 1. The internal consistency reliability of the nine criteria of the manual for the self detection of depression in the Thai elderly ranged from 0.84 to 0.94. The validity tested by epidemiological methods, disclosed that the sensitivity was 82.14 per cent and the specificity was 97.56 per cent. 2. There was a statistically significant difference in the incidence of depression between the study and the control group (p<0.000); self referred cases = 86.7 per cent and 9.8 per cent respectively. The study group was able to detect depression in 42 days, while the control group did so in 122 days. In addition, in the associated comorbidity, there were differences in the patterns of drug and alcohol abuse, suicidal ideas and quality of life after the experiment. These findings showed a decreasing pattern of self medication for depression, and suicidal ideas and an improvement in the quality of life in the study group.
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PMID:Research on development of the manual for self detection of depression in the Thai elderly. 1218 83

Efforts to eradicate brucellosis caused by Brucella abortus in the United States began in 1934 as part of an economic recovery program to reduce the cattle population because of the Great Depression and concurrent severe drought conditions. A number of states saw this as an opportunity to reduce the level of brucellosis, which was the most significant livestock disease problem in the US at the time. In 1934 and 1935, the reactor rate in adult cattle tested was 11.5%. In 1954, the magnitude of the brucellosis problem in the United States in terms of economics to the cattle industry and human health prompted Congress to appropriate funds for a comprehensive national effort to eradicate brucellosis. The brucellosis eradication program was designed as a cooperative effort between the federal government, the states, and livestock producers. As the science and technology of brucellosis has developed over the years through research and experience, the eradication program has been modified many times. As of 31 December 2000, there were no affected cattle herds in the United States. This was the first time in the history of the brucellosis program that the United States had no known brucellosis affected herds. However, brucellosis has a variable, sometimes quite lengthy incubation period, so it is expected that additional affected herds will be disclosed. It is likely that additional affected herds will be disclosed before brucellosis is finally eradicated from cattle. Animal health officials remain prepared to aggressively pursue any newly disclosed affected herds to eliminate the disease as quickly as possible. The State-Federal Brucellosis Eradication Program has made tremendous progress since its inception. In an eradication program, it is critically important to recognize that, despite all the tools that are available to eliminate the disease, an effective surveillance system is the critical first step that must be in place in order to be successful. It is imperative, not only to be able to find the disease and eliminate it, but to find it before it spreads to susceptible herds. When brucellosis can be identified, contained, and eliminated before spread occurs, eradication can be achieved.
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PMID:The Animal and Plant Health Inspection Service (APHIS) brucellosis eradication program in the United States. 1241 29

Neonatal and weaner Gulf Coast Native (Native) lambs were studied to determine whether an immunological basis underlies their natural resistance to Haemonchus contortus infection. Neonatal Native lambs (n = 8) and weaner Native lambs (n = 15) were randomly assigned to a treatment or a control group. Lambs in the treatment group received dexamethasone by intramuscular injection three times a week for 10 weeks (neonatal) and 15 weeks (weaners). All lambs were monitored for fecal egg count (FEC), blood packed cell volume (PCV), and white blood cell differential counts on a weekly basis for the duration of the studies. Neonatal lambs were kept on pasture with their dams and weaner lambs were dewormed at weaning and kept in pens where they received trickle infections. Serum antibody titers to H. contortus whole worm antigen (WWA) were determined using ELISA. Lymphocyte proliferation assays on peripheral blood mononuclear cells (PBMC) were done to assess lymphocyte function. All lambs were vaccinated with killed Brucella abortus strain 19 to assess the effect of dexamethasone treatment on antibody response. All lambs were necropsied at the end of each study to recover the contents of the gastrointestinal tract for nematode enumeration and identification. The results showed that mean FEC and mean PCV of the treatment group was significantly higher and lower, respectively, than in the control group in both neonatal and weaner lambs from weeks 6 and 5, respectively. At necropsy, total nematode count was significantly higher in treatment groups than in the control groups. Serum antibody titers to H. contortus WWA were significantly lower in treated groups than in control groups. Treatment groups showed a consistent depression in lymphocyte percentage being significantly lower from week 6 in both neonatal and weaner lambs. No differences were found in the response of PBMC to mitogen stimulation between the groups. Lambs in the control groups showed strong positive brucellosis card tests and the treatment groups did not. Dexamethasone treatment resulted in depression of the immune response and loss of natural resistance of Native lambs to H. contortus infection. The results of these studies suggest that some aspects of the immune response may underlie the natural resistance of Native sheep to H. contortus infection.
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PMID:Effect of dexamethasone treatment on the immune response of Gulf Coast Native lambs to Haemonchus contortus infection. 1474 81


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