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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sixty-five cases of mental depression were treated with maprotiline (Ludiomil), including 46 cases of endogenous depression, 18 cases of neurotic depression and 1 case of depression in association with hypertension and cerebral arteriosclerosis. Ludiomil of 50-200 mg/d was given for 4 weeks and clinical pictures evaluated weekly. Clinical results showed complete recovery in 33 cases (50%), improvement in 22 cases (34%), fair in 7 cases (11%) and poor in 3 cases (5%). Dry mouth, constipation and faintness were the commonest side effects. Seizure occurred in 1 case and skin rash in 3 cases. The authors suggest that Ludiomil at a maximal dosage of 150 mg/d can be considered a relatively safe and effective antidepressant.
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PMID:Maprotiline (Ludiomil) treatment of mental depression--a clinical report of 65 cases. 259 36

48 consecutive male patients of potency disorders were examined and classified as 'Dhat' syndrome, impotence or premature ejaculation. The age range of these cases was found as 20-38 years (mean 23.5 +/- 3.3 years) while age of onset was 16-24 years (mean 20.6 +/- 4.5 years). Majority of cases were unmarried (54.2%) and educated 5th class or above (79.1%). 31 cases (64.6%) had Dhat syndrome with or without impotency and/or premature ejaculation while 7 cases (14.6%) had only premature ejaculation and 10 cases (20.8%) only impotence. The cases with 'Dhat' syndrome or with impotence scored maximally on neuroticism and depression scales. Neurotic depression was the commonest associated psychiatric illness (39.5%) followed by anxiety neurosis (20.8%) while 31.3% did not have any possible diagnosis. The common presenting symptoms of 'Dhat' syndrome include weakness (70.8%), fatigue (68.7%), palpitations (68.7%), sleeplessness (62.4%) etc. Among the four groups on the basis of type of treatment (antianxiety drug, antidepressant, placebo, psychotherapy), the best response was seen in those receiving antianxiety or antidepressant drugs while those receiving psychotherapy showed minimal response. 7 cases (14.6%) dropped out of treatment and the maximum dropout (40.6%) was seen in psychotherapy group.
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PMID:'Dhat' syndrome--a useful clinical entity. 263 75

This study reports the antidepressant efficacy and the safety of amineptine (Survector 100) in a national multicenter open clinical trial (32 hospital centers). Three hundred twenty-four patients with depressive disorders, selected according to DSM-III Diagnostic Criteria and INSERM classification, were treated with amineptine (200 mg/day) for 40 days (mean). Amineptine proved to be significantly effective with a rapid onset of action (beginning on the 7th day) on depressive symptoms, as shown by the decrease in the Hamilton Depression Rating Scale total score. The assessment of the results in the different diagnostic subgroups confirmed the wide-spectrum antidepressant activity of amineptine. Particularly in reactive and neurotic depression (nonpsychotic depression according to INSERM) and dysthymic disorders according to DSM-III, amineptine induced an improvement in 90% of patients. Nevertheless, amineptine was also effective in psychotic depression (INSERM) and in major depressive episodes (DSM-III), in which improvement occurred in 76% of patients. The low frequency of side effects and the remarkable acceptability (clinical, biological, and cardiovascular) of amineptine were also confirmed.
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PMID:A multicenter Italian study of amineptine (Survector 100). 269 70

The authors analyse the findings of a clinical simple-blind trial of the drug Insidon--Geigy in depressive states. This drug was administered in monotherapy for 28 days in average doses of 150 mg daily in a series of 20 inpatients of both sexes and aged 20-60 years, diagnosed with neurotic depressive state. The efficiency of the treatment and its tolerance were estimated on a special Ciba-Geigy Pharma International investigation card through clinical observation, scoring of clinical items, psychological check-up and Hamilton's scale for depression at 0-7-14-21 and 28 days, paraclinical investigations, computer processing (TIM-S) on the basis of a program (in BETA BASIC language in 3.1 version) necessary for determining the polynomial functions for the significant items of the psychopathological syndrome (anxiety, depression, insomnia). The corroboration of the data of clinical and paraclinical observations with the psychologic examination and the computer-processed data reveals the clinical efficacy of Insidon--Geigy in neurotic depression, its good tolerance and low incidence of side effects.
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PMID:[The treatment of depressive states with opipramol (Insidon--Geigy)]. 281 12

One hundred twenty-nine patients who were treated by lumbar laminectomy for discogenic disease were evaluated preoperation by means of the Millon Clinical Multiaxial Inventory (MCMI) and the Minnesota Multiphasic Personality Inventory (MMPI). At follow-up evaluation, there were 71% good, 18% fair, and 11% poor surgical results. Patients with fair or poor outcomes scored significantly higher in the hypochondriasis, depression, hysteria, and psychasthenia scales in preoperative MMPI testing. These patients also showed significant differences on the MCMI asocial, gregarious, and neurotic depression scales. The MMPI profiles had a higher correlation with successful treatment than did those of the MCMI. The MMPI can help identify patients whose pain syndrome has a significant psychosocial component, and it can easily be used by orthopedic surgeons to facilitate referral and treatment planning.
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PMID:A comparison of the Millon Clinical Multiaxial Inventory and the Minnesota Multiphasic Personality Inventory as predictors of successful treatment by lumbar laminectomy. 293 95

Low parental care and parental overprotection have been incriminated as risk factors to depression in adult life. The relevance of these parental characteristics to broad depressive 'types' with their varying imputed aetiologies was assessed by having 26 patients with endogenous depression (ED) and 40 with neurotic depression (ND) complete the Parental Bonding Instrument (PBI) self-report measure. In comparison to their controls, the EDs did not differ on the parental care and overprotection scales. The NDs, by contrast, were more likely than their controls to report their parents as uncaring and overprotective. A PBI care scale score of less than 10 was particularly discriminating, being reported by 3.8% of the EDs and 37.5% of the NDs. While findings support the binary view of depression in terms of broad imputed aetiological factors, several response biases which might influence the findings are considered.
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PMID:Parental representations of neurotic and endogenous depressives. 295 3

Ninety-one subjects diagnosed clinically as having a 'neurotic depression' were interviewed and then re-assessed at 6 weeks and 20 weeks. Four symptom profiles of clinical features were derived: 'negative cognition', 'lack of drive', 'anxiety', and 'arousal', the last being independent of the other three dimensions and of the severity of depression. Symptom profile scores were then examined against antecedent risk variables and outcome. Links between profile scores and personality variables suggest that personality may colour the clinical presentation of neurotic/reactive depressions, and challenge the assumption that a typology of these depressive disorders based on clinical features is achievable. The break-up of an intimate relationship in the preceding 12 months was a strong predictor of a good outcome. Further analyses suggested, firstly, that there was a distinct subgroup delineated by this life event, with features weighted to the 'arousal' symptom profile, including many symptoms often associated with diagnosis of 'endogenous depression'; and, secondly, that this life event and a good outcome were directly linked, being uninfluenced by personality or other mediating variables.
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PMID:Neurotic depression: delineation of symptom profiles and their relation to outcome. 316 32

Contrasting the classification systems ICD-9 and DSM-III-R, a comparison of diagnoses for unipolar depressive disorders is presented from a sample of 168 psychiatric outpatients. A relatively clear correspondence existed between ICD-9 endogenous depression and DSM-III-R major depression. Neurotic depression (ICD-9) divided into either dysthymia or major depression in DSM-III-R. A generally greater variety of corresponding ICD-9 diagnoses was observed for DSM-III-R categories, since patients with eating disorders, alcohol or drug dependence, or with neuroses other than depressive type often received an additional specific DSM-III-R diagnosis for depression. For ICD-9 diagnostics, a decreased threshold was found for diagnosing depressive reaction, as compared with the equivalent DSM-III-R diagnosis of adjustment disorder with depressed mood. A new technique is introduced in order to adjust corresponding proportions according to base rate differences.
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PMID:Divergence and convergence of diagnoses for depression between ICD-9 and DSM-III-R. 321 19

To study manifestations of the depressive personality development, the authors followed up 48 women (of the total number of 143 patients) exposed to long-term objectively unsolvable psychogenically traumatizing situation related to a child's disease. The symptomatology of depressive neurosis had undergone a typical course by the moment of examination: the acuteness, vividness and lability of the affect had disappeared, being replaced by its monotony; depression of the psychic activity in all spheres of life had deepened and strengthened, faith in a favourable resolution of the situation had been fully lost; new traits related to anxiety-dysthymic attitude toward people and events had formed; psychosomatic diseases had developed in the presence of marked vegetative manifestations. Clinical variants of depressive personality development are described. A conclusion is drawn about the typical eventuality of a depressive neurosis in the depressive development of the personality.
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PMID:[Clinical characteristics of the depressive development of personality]. 324 81

One hundred and forty-five patients with primary depressive illness admitted to a university hospital between 1966 and 1970 were followed up an average of 15 years later. Adequate data were obtained on 133 (92%) of the 145. During the follow-up period, 7% of the 133 had suicided, 12% had remained incapacitated by illness and only 20% had remained continuously well. Patients for whom the index admission was not their first were especially likely to be readmitted during the follow-up period. Patients with endogenous depression, none of whom developed schizophrenia during the follow-up period, were more likely to need readmission than patients with an index diagnosis of neurotic depression. In all other respects the prognosis for the two types of depression was the same, with considerable morbidity evident in both.
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PMID:The long-term outcome of depressive illness. 249 26


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