Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ventilatory depression and apnea are well-known early pulmonary responses of sepsis in infants, yet their underlying mechanisms are not understood. To further elucidate the pathophysiology, we induced Escherichia coli septicemia in piglets and studied the sequential changes in intrapulmonary shunt (QS/QT), physiological dead space (VD/VT), minute ventilation (VE), and blood gases for up to 6 hours of lethal sepsis. Lung lymph was also collected and extravascular lung water (EVLW) was measured. Histology confirmed that interstitial edema developed 1 hour after E. coli infusion. These data suggest that high permeability pulmonary edema and hypoxemia following early intrapulmonary shunt increase may be the causes of septic ventilatory depression.
 ...
PMID:[An experimental study on the pathophysiology of septic ventilatory depression]. 165 Jun 39

The influence of a moderate, standardized trauma on bacterial and endotoxin kinetics in post-traumatic Escherichia coli septicemia was studied in a porcine model. Septicemia was induced by intravenous infusion of live E. coli (2.5 x 10(9) cfu/kg, rough:K5:H6) into 14 piglets. Seven of these animals had been exposed to moderate trauma 48 hours previously. Following the E. coli infusion, cardiovascular signs of severe septicemia appeared in all the piglets, associated with gradual increase in the blood bacterial count and the plasma levels of endotoxin. This increase was significantly less pronounced in the animals with prior moderate trauma than in the nontraumatized animals. Thus no depression of the host defense system was demonstrable 2 days after moderate trauma.
 ...
PMID:Depression of plasma endotoxin levels during gram-negative septicemia subsequent to moderate trauma. 266 91

Animal experiments were carried out to investigate whether a protective effect can be achieved in endotoxemia by intravenous (i.v.) application of a polyclonal immunoglobulin preparation (IVIG-IgG/A/M) enriched with 12% IgM and 12% IgA. Following administration of IVIG-IgG/A/M (500 mg/kg), endotoxemia was induced by intraperitoneal inoculation of a sublethal dose (5x10(8) CFU/kg) of Escherichia coli (E. coli) and subsequent i.v. administration of an antimicrobial agent (Imipenem). Plasma endotoxin activity, IL-6 activity, mean arterial pressure, and skeletal muscle oxygen pressure (tpO2) were measured at regular intervals over a total observation period of 7 h. Prophylactic administration of IVIG-IgG/A/M was found to significantly attenuate (P<0.01) the antibiotic-induced increase in endotoxin activity as compared to the albumin control group. Limited endotoxemia in the IgG/A/M group was associated with reduced levels of circulating IL-6 (P<0.01). Both lipopolysaccharide-induced hypotension and depression of tissue oxygenation were attenuated (P<0.01) by pre-treatment with IVIG-IgG/A/M. The experimental results suggest that in endotoxemia the polyclonal immunoglobulin preparation has a prophylactic protective effect on the acute phase responses and reduces the cardiodepressant effects of E. coli septicaemia.
 ...
PMID:Protective capacity of a IgM/IgA-enriched polyclonal immunoglobulin-G preparation in endotoxemia. 1036 88