Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this paper is to review ways in which the neurohormonal system can interact with the immune system and to outline the main mechanisms which are involved in this interaction. Experimental as well as clinical evidence is presented to support the existence of a close interaction and bi-directional communication between the central nervous and immune systems. The role of major endocrine mechanisms and hormones is discussed. The evidences from experimental work to support the roles of the nervous system with neurotransmitters, the endocrine system with hormones, and the immune system with cytokines are presented. Aging, depression and cancer have a high degree of co-association and share mechanisms which result in cellular immune deficiency. Hormone therapy, zinc replenishment, antidepressants, immunomodulators like MDP act on these pathways to upregulate and improve cellular immunity. The authors believe that the central nervous system (CNS)-immune interaction is an important new frontier to be considered for new combination therapy in diseases with cellular immune deficiency such as cancer particularly in the aged with depression.
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PMID:Neuroendocrine immune interactions in health and disease. 1286 Jan 79

Depression can be disguised by somatic symptoms, chronic pain, hypochondriacal or psychosomatic disorder. The predominant somatic presentation may render such cases to be misdiagnosed, wrongly investigated and treated. In this study 30 consecutive patients diagnosed as MDP Depression, who lacked sadness but presented with chronic pain have been described. The patients were mainly female, middle aged and from urban background. Pain, usually at multiple sites, was reported to be severe by most patients. Predominant depressive symptoms were lack of interest in surrounding (97%), though this was not directly reported, early morning a wakening (87%), loss of appetite (93%), suicidal ideas (67 %). None had marked sadness or weeping spells. Lack of reactivity of mood was present in only two cases. The clinical implications of such patients is discussed.
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PMID:Depressive psychosis presenting as chronic pain disorder. 2192 44

Complete clinical data of 50 consecutive patients of MDP registered at the Hospital for Psychiatric Diseases Srinagar from 1st December 1970 onwards was examined retrospectively in 1986 to determine the relationship between seasonal variations and occurence or recurrence of affective disorders. The highest number of attacks of mania occured during summer, whereas the highest number of attacks of depression occurred during later half of winter and early half of spring.
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PMID:10-15 years retrospective study of 50 patients of mdp for seasonal variations. 2192 19


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