Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The incidence and morbidity factors as regards non-psychotic depression during the puerperium (puerperal blues or maternity blues or post-partum blues) has been investigated in 50 females at random. Puerperal blues was diagnosed as the presence of depression in keeping with Kellner's symptomatic questionnaire. Approximately two-thirds of women experience depression during the early puerperium. Primiparas, patients who have had traumatic delivery (cesarean delivery) and those who have had considerable traumatic experience during pregnancy, and/or presented a previous history of psychopathological disorders, are more subject to puerperal blues.
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PMID:[Early puerperal depression: the puerperal blues]. 279 99

Panic attacks occurred for the first time in a patient suffering from delusional depression during treatment with a combination of an antidepressant and a neuroleptic. His anxiety proneness along with a dysphoric response to the neuroleptic were deemed responsible for these attacks. It is proposed that neuroleptic-induced dysphoric responses may be responsible for therapeutic failure in some cases of psychotic depression.
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PMID:Neuroleptic-induced panic attacks in a patient with delusional depression. 288 74

Antipsychotic drugs have an important place in pharmacologic treatment of depression. Major depression with psychotic features responds poorly to treatment if an antipsychotic is not used in addition to an antidepressant; however, an antipsychotic confers no additional benefit in nonpsychotic depression. Antipsychotic drugs do have significant short- and long-term side effects, including pseudoparkinsonism, dystonia, akathisia, and tardive dyskinesia. The possibility of a good therapeutic response with minimal side effects can be increased if psychotic depression is diagnosed accurately and the antipsychotic is prescribed according to established clinical guidelines.
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PMID:Use of antipsychotic drugs in depression. Problems and opportunities. 289 Nov 24

Forty-three inpatients with RDC schizo-affective depression were given structured interviews and then followed to 1 year using a design closely resembling that of another recent follow-up of schizo-affective patients. In replication of the earlier study, patients with either 'chronic' or 'mainly schizophrenic' schizo-affective disorder had significantly worse outcomes than did patients with nonchronic or 'mainly affective' schizo-affective depression and bipolar patients were significantly more likely to develop manic syndromes. The preceding duration of schizophrenia-like symptoms and a history of schizophrenia-like prodromes appeared to be the most important components of these two distinctions. In both studies, diagnostic subtype was the most robust of various potential outcome predictors. Also in both studies, 'mainly affective' and 'nonchronic' schizo-affective patients had outcomes no different from patients with psychotic depression.
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PMID:Diagnosis and outcome in schizo-affective depression: a replication. 297 Apr 89

Mental-hospital admission rates in Edinburgh for mania, schizophrenia and psychotic depression were studied from 1970 to 1981, a 12-year period during which long-term lithium therapy was increasingly employed in affective illnesses. If this treatment had been effective admission and readmission rates for mania, and perhaps also for depression, should have fallen progressively. In fact, they rose steadily, while the admission rate for schizophrenia fell. These changes could not easily be attributed to changing diagnostic criteria, to the admission of milder affective illnesses, or to poor and deteriorating lithium surveillance. Their explanation is uncertain, but they cast some doubt on the efficacy of lithium prophylaxis in ordinary clinical practice.
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PMID:Does maintenance lithium therapy prevent recurrences of mania under ordinary clinical conditions? 309 48

A sample of 31 schizophrenic patients free of anti-psychotic drugs was examined on admission to hospital. 14 (45%) exhibited depressed mood. The course of depressive symptoms and psychotic symptoms was followed weekly while the patients received increasing doses of haloperidol in a standardised regime. In 11 of the 14 patients there was a close correspondence between the course of depressive and psychotic symptoms, suggesting that in these cases, depression was an integral part of the schizophrenic illness. In the other three cases, clinical course of the various symptoms gave some support to the concepts of 'pharmacogenic' and 'post-psychotic depression', although it was not possible to choose between them.
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PMID:The clinical course of depressive symptoms in schizophrenia. 315 2

The authors examined the fluphenazine decanoate dose and the fluphenazine plasma levels in comparison with measures of severity of depression in schizophrenic and schizoaffective patients. All patients were selected for study on the basis of having stable, syndromally defined, antiparkinsonian non-responsive syndromes of post-psychotic depression. No meaningful relationships were found. The implications of this observation with regard to the notion that depressive symptomatology in such patients is neuroleptic-induced is discussed.
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PMID:Fluphenazine decanoate dose and severity of depression in patients with post-psychotic depression. 315 4

The occurrence of mood changes in the postpartum period is common. This presentation will discuss three cases of postpartum mood changes illustrating the "normal" changes, depression with suicidal ideation requiring brief hospitalization, and psychotic depression requiring intensive psychiatric treatment.
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PMID:Postpartum depression. 334 Aug 74

Ninety-one consecutively admitted patients with schizophrenia (n = 21), schizoaffective depression (n = 43), or psychotic depression (n = 27) entered a blind family study along with 36 never-ill controls. Though schizophrenia spectrum disorders clustered within families, they were not significantly more prevalent in the families of schizophrenic probands. In contrast, morbid risks for affective disorder clearly separated the families of psychotically depressed probands from the families of both schizophrenics and controls. Family study data for schizoaffective probands indicated links to both affective disorder and schizophrenia and suggested, as well, that a small number of patients with schizoaffective disorder may carry a genetic liability to both conditions.
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PMID:The heritability of schizophrenia and schizoaffective disorder. A family study. 335 19

Despite substantially greater levels of impairment during the five years preceding intake to this study, patients with nonbipolar psychotic depression (n = 55) were as likely to recover as were patients with nonpsychotic depression (n = 451) during a 2-year follow-up. Though patients with psychotic depression were more psychosocially impaired at 6 months, these differences resolved during the ensuing 18 months. In replication of an earlier study, early outcome was more predictive of later outcome in psychotic patients than it was in nonpsychotic patients.
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PMID:The importance of psychotic features to major depression: course and outcome during a 2-year follow-up. 357 43


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