Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An investigation has been made with regard to the clinical picture of 87 terminally ill patients with lung cancer. It has yielded the following points. 1) Seven patients had been informed of their diagnosis. 2) Intravenous hyperalimentation was administered in 78 cases (90%), oxygen therapy in 68 cases (78%), and morphine in 35 cases (40%). 3) The most frequent cause of death in these patients was respiratory failure, due to progress of cancer, then infection, pleural, or pericardial effusion, or interstitial pneumonitis. 4) Psychic disturbances involved anxiety over breathing, depression, and delirium. In only 12% of the patients did the mental condition seem normal until death. 5) To deal with the dying patient's needs, it is necessary to establish proper treatment for the control of sensory dyspnea and for psychosocial support by a psychiatrist and other professionals for members of the family.
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PMID:[The clinical picture of terminally ill patients with lung cancer]. 250 34

The sensitivity of human melanoma and lung cancer strains transplanted to nude mice to the synthetic hormone of hypothalamus--melanostatin has been defined. Correlation has been noted between the rate of melanoma growth inhibition, decrease in the rate of Na-fluorescent accumulation in the tumor and the tendency towards depression of the activity of energetic metabolism enzymes (SDH and alpha-GPDH) in the treated tumors as compared to control. Moderate lymphopenia and absence of effect on the same enzymes of the lymphocytes was also observed. Fluorescent probes can be used in the estimation of the drug action on the tumor and organs.
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PMID:[The action of hypothalamic hormone on athymic mice with transplantable strains of human tumors]. 290 87

Several animal studies have demonstrated that pain is modulated by spinal mechanisms involving prostaglandins and that acetylsalicylic acid (ASA) administered intrathecally has an analgesic effect. We report our experience of this treatment in 60 patients with proven and advanced cancer. An isobaric solution of lysine acetylsalicylate was administered by lumbar puncture in doses ranging from 120 to 720 mg of ASA. The results were evaluated using the habitual criteria: scoring system, behaviour, consumption of analgesic drugs. In this trial the method proved astonishingly effective (78% of the cases). Analgesia was strong, almost immediate and without influence on motricity. No thermic or neurovegetative changes were noted. The effect of one injection lasted from 3 weeks to 1 month on average; it was reproduced and often more prolonged after a repeat injection. Pain associated with bone metastases seems to constitute the best indication, notably in breast and lung cancer and in myeloma. Visceral (pancreas) or neural pain requires higher doses to respond. Failures (22%) were due to such factors as insufficient dosage at the very beginning of our experience or severe depressive syndrome. The perineal and sphincteral pain of rectal cancer often resists treatment. This simple, inexpensive and very effective method with no other complication than a frequent tendency to fatigue should rank among other analgesic measures in cancer. The lack of respiratory depression is a major advantage over catheter spinal opiate analgesia. We consider that its main indications are pain associated with osteolytic metastases of adenocarcinomas, and myelomas. Owing to the absence of formal toxicological data, its use must be limited to cancer pain and to patients with a life expectancy of less than 2 years.
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PMID:[Chronic refractory pain in cancer patients. Value of the spinal injection of lysine acetylsalicylate. 60 cases]. 295 75

Phytohemagglutinin (PHA)-induced interleukin 2 (IL-2) production and lymphocyte proliferation were measured in former workers of the Okunojima Poison Gas Factory (poison gas workers), who have a high incidence of lung cancer, and the efficacy of administration of Nocardia rubra cell wall skeleton (N-CWS) was studied. In comparison with normal controls and poison gas workers receiving N-CWS, lymphocyte proliferation in poison gas workers not receiving N-CWS showed a significant decrease, while IL-2 production showed a slight though not statistically significant decrease. When N-CWS was administered to poison gas workers, IL-2 production and lymphocyte proliferation were significantly elevated, with a peak two weeks after administration. N-CWS, by elevating IL-2 production of lymphocytes, is considered to have improved the depression of lymphocyte proliferation.
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PMID:Effects of Nocardia rubra cell wall skeleton on interleukin 2 production and lymphocyte proliferation in former poison gas factory workers. 308 31

Cytotoxic activities of regional lymph node lymphocytes (RLNL) and peripheral blood lymphocytes (PBL) of 49 primary lung cancer patients who were subjected to surgical resection were examined by 4 h 51Cr release assay. PBL showed significantly lower cytotoxicity against autologous tumor cells than against K562 and QG-56. On the other hand, RLNL exhibited the same level of cytotoxicity against autologous tumor cells as PBL, although the cytotoxicities against K562 and QG-56 were low. Cytotoxicity of RLNL against autologous tumor cells exhibited a significant degree of depression with the advance of stage, T and N factors. Cytotoxicity of PBL did not significantly change as the stage progressed. When both PBL and RLNL were cultured with purified interleukin-2 (p-IL2) in vitro, their cytotoxic activities were markedly augmented and the cytotoxicities could not be diminished by the treatment with anti-Leu-7 + anti-Leu-11b + C'. These facts indicate that the augmented cytotoxicity may be due to lymphokine activated killer (LAK) cells.
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PMID:Antitumor activity of regional lymph node lymphocytes in patients with lung cancer. 326 Jun 43

Twenty-two (16%) of 134 lung cancer patients had symptoms of a major depressive illness at the time they first presented to hospital. This was a higher prevalence than that found in patients with non-malignant chest conditions, or in controls without serious disease. A past history of psychiatric illness, and the presence of metastatic disease, were the most significant correlates of depression. The depressive symptoms had often preceded the physical ones and apparently arisen in reaction to social stress.
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PMID:Depressive illness and lung cancer. I. Depression before diagnosis. 398 8

Today there seems to be sufficient data to incriminate benzene as a potent carcinogenic agent causing leukemia, malignant lymphoma, multiple myeloma and lung cancer, as well as numerous disorders of the bone marrow depression. Other factors (such as genetic and individual susceptibility) may have a role in the development of these different types of malignancies and hematologic disorders. In this paper, data concerning all these problems are presented and discussed.
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PMID:Benzene as a leukemogenic and carcinogenic agent. 402 42

Life table analysis and partial correlation analysis have been used to examine the importance and interaction of those factors reported to affect prognosis in lung cancer, in a group of men taking part in a recent trial (Anthony et al. 1978). In patients with squamous carcinoma the lymphocyte count at diagnosis was a genuine correlate of survival, those with higher counts living longer. Patients who had smoked more heavily were younger when their tumours were found, had better differentiated carcinomas and longer survival. Those with poorer differentiation had weaker skin test reactivity but the expected shorter survival was seen only when controls for symptom pattern history and resectability were applied. These data could be explained by control of tumour extension by cell-mediated immunity, earlier induction of better differentiated tumours in heavier smokers, more insidious onset of symptoms in those with better differentiated tumours and the depression of cell-mediated immunity by poorly differentiated tumours. In contrast, the longer survivors among patients with oat cell carcinoma had lower lymphocyte and monocyte counts at the time of diagnosis. Lymphocyte and monocyte counts contributed independently to survival in keeping with oat cell carcinoma being lymphodependent (Prehn 1977) and resistant to immune cytolysis.
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PMID:Lung cancer, immune status, histopathology and smoking. Is oat cell carcinoma lymphodependent? 626 45

Thirty-one patients with metastatic brain tumors were treated with Radiotherapy (RT) and CCNU or with RT, CCNU and Levamisole (LMS) in a randomized clinical trial. Twenty-seven were evaluable. All patients were submitted to whole brain radiation (50 +/- 5 Gy) and CCNU (130 mg/m2 p.o. every 8 weeks). 15 also received Levamisole (2.5 mg/kg p.o. daily for 3 weeks in the first month, for 2 weeks in the second, and then once a week monthly until progression). Primary tumor was predominantly lung cancer (22/27) and brain lesions were generally multiple (24/27). The overall response rate was 35% in the RT plus CCNU treated group and 38% in the RT plus CCNU plus LMS treated group. The median survival time was similar and not statistically different in both groups (7 versus 6 months). No important side effects were observed either in the RT + CCNU or in the RT + CCNU + LMS treated groups. The absence of combined depression of T-cell levels and responsiveness of lymphocytes to mitogens suggests that thymus dependent immunity could be improved by LMS administration. However, such improvement had no impact on duration of survival in patients with metastatic brain tumors.
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PMID:Radio-chemo-immunotherapy (CCNU plus levamisole) for treatment of metastatic brain tumors. A pilot study. 633 42

The immune responses of patients with lung cancer undergoing therapeutic irradiation were evaluated. Absolute lymphocyte counts, PPD skin test, PHA skin test and in vitro lymphocyte transformation test with PHA were performed on each patient before and after 40 Gy irradiation. The values of these parameters were depressed as the increment of the irradiated dose, OK-432 and PS-K administration combined with radiotherapy suppressed the depression of the PHA skin test reactivity and in vitro lymphocyte transformation with PHA. Adding to the effect on immune response of the whole body, the local radiation effect on immunological reaction of tumor tissue was also evaluated.
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PMID:[Effect of therapeutic irradiation on the immune responses]. 666 63


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