Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty-five rape victims who had been assaulted from 2 to 46 years earlier were interviewed to determine the long-term effects of sexual assault. Victims were compared to 110 nonabused matched control subjects on their scores on the State-Trait Anxiety Inventory, the Beck Depression Inventory, and the modified Fear Survey Interview. An analysis was also conducted to determine which of the factors characterizing the rape situation had an influence on the victims' scores. Rape victims were found to be significantly more depressed, generally anxious, and fearful than control subjects. Only one rape situation variable, the survivor having been a prior victim of sexual assault, was found to be related to a higher degree of depression and anxiety.
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PMID:Long-term psychological effects of rape in 35 rape victims. 406 92

The Beck Depression Inventory was used to assess depressive symptoms in 178 sexual assault survivors and 50 control subjects who had never been sexually assaulted. The sexual assault survivors reported significantly more depressive symptoms than the control subjects, and further analyses strongly suggested that the depressive symptoms were caused by the sexual assault. Investigation of the relationships between depression scores and survivor and assault characteristics indicates that the nonspecifics of the assault and the use of a weapon by the assailant were most highly correlated with development of depressive symptoms.
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PMID:Depressive symptoms associated with sexual assault. 651 70

1. Military personnel exposed to war-zone trauma are at risk for developing PTSD. Those at greatest risk are those exposed to the highest levels of war-zone stress, those wounded in action, those incarcerated as prisoners of war, and those who manifest acute war-zone reactions, such as CSR. 2. In addition to problems directly attributable to PTSD symptoms per se, individuals with this disorder frequently suffer from other comorbid psychiatric disorders, such as depression, other anxiety disorders, and alcohol or substance abuse/dependence. The resulting constellation of psychiatric symptoms frequently impairs marital, vocational, and social function. 3. The likelihood of developing chronic PTSD depends on premilitary and postmilitary factors in addition to features of the trauma itself. Premilitary factors include negative environmental factors in childhood, economic deprivation, family psychiatric history, age of entry into the military, premilitary educational attainment, and personality characteristics. Postmilitary factors include social support and the veteran's coping skills. 4. Among American military personnel, there are three populations at risk for unique problems that may amplify the psychological impact of war-zone stress. They are women whose war-zone experiences may be complicated by sexual assault and harassment; nonwhite ethnic minority individuals whose premilitary, postmilitary, and military experience is affected by the many manifestations of racism; and those with war-related physical disabilities, whose PTSD and medical problems often exacerbate each other. 5. The longitudinal course of PTSD is quite variable. Some trauma survivors may achieve complete recovery, whereas others may develop a persistent mental disorder in which they are severely and chronically incapacitated. Other patterns include delayed, chronic, and intermittent PTSD. 6. Theoretically primary preventive measures might include prevention of war or screening out vulnerable military recruits. In practice, primary preventive measures have included psychoeducational and inoculation approaches. Secondary prevention has been attempted through critical incident stress debriefing administered according to the principles of proximity, immediacy, expectancy, and simplicity. Tertiary prevention has included psychotherapy, pharmacotherapy, dual diagnosis approaches, peer counseling, and inpatient treatment. Few treatments have been rigorously evaluated. 7. There are both theoretical reasons and empirical findings to suggest that military veterans with PTSD are at greater risk for more physical health problems, poorer health status, and more medical service usage. Much more research is needed on this matter. 8. Despite the potential adverse impact of war-zone exposure on mental and physical health, there is also evidence that trauma can sometimes have salutary effects on personality and overall function.
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PMID:Post-traumatic stress disorder in the military veteran. 793 58

The effect of the victim-offender sexual assault relationship on women's psychological symptomatology was examined in a randomized community survey. Fourteen and one-half percent of women (N = 240) experienced a sexual assault in adulthood. Assaults committed by strangers, acquaintances, and intimates were compared using both chi-square and two-way analyses of variance. Few differences were found in sexual assault experiences according to the victim-offender relationship. Offender use of violence showed a curvilinear relationship with degree of closeness of the victim-offender relationship, whereas victim resistance did not vary according to the victim-offender relationship. Analyses of psychological symptom measures showed that sexual distress was more common for women attacked by intimates, fear/anxiety was more common for women assaulted by strangers and depression did not vary according to the victim-offender relationship.
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PMID:Victim-offender relationship and sexual assault. 819 54

Although the majority of childhood sexual abuse victims are women, male children are also at risk for sexual assault and consequent long-term effects including major psychiatric disorders, substance abuse, sexual dysfunction, and somatization syndromes. Male patients sexually abused in childhood or adolescence may present to the primary-care physician with specific interpersonal or developmental crises or with persistent depression, anxiety, or somatic complaints. The physician can serve a therapeutic role by validating the patient's experience and can provide the patient with information on the prevalence and consequences of male sexual abuse. Assessment of the impact of sexual abuse will rely on the sensitive and systematic evaluation of critical variables related to the abuse. More severely traumatized patients will require assessment for suicide potential and referral for mental health services.
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PMID:Men sexually abused in childhood. Sequelae and implications for the family physician. 825 33

The purpose of this study was to evaluate the functional impact of sexual assault history in two general population surveys (pooled N = 6,024). Sexual assault was associated with functional impairment regardless of gender, ethnicity, and study site. Repeated assaults, spousal assaults, physically threatening assaults, and those resulting in intercourse or sexual disturbances were most strongly related to impairment. The greater numbers of severe physical symptoms experienced by sexually assaulted persons accounted for their poorer functioning. Depression did not account for this association despite its mediating role. Physical symptoms and depression had similar relationships to functioning for assaulted and nonassaulted persons.
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PMID:Sexual assault history and limitations in physical functioning in two general population samples. 855 1

Sexual abuse consists of two discrete traumatic elements; the repeated infliction of sexual assault that is superimposed on a chronic background of pathological family interaction, including betrayal, stigmatization, role reversal, and violation of personal boundaries. The acute episodes of sexual assault may be overwhelming to the child and result in anxiety-related symptoms, including PTSD. The long-standing family dysfunction leads to a pathological defensive organization that becomes woven into the victim's personality structure, resulting in long-term characterological changes. As the sexually abused child progresses through adolescence into adulthood, and the immediacy of his or her victimization recedes to the background, the acute posttraumatic anxiety symptoms are gradually replaced by more enduring symptoms and characterological defenses. Traumatic memories of the abuse become repressed or dissociated from consciousness. Identifications, attitudes, and affects derived from the abusive environment are usually organized around victimization experiences, leading to identifications with the aggressor or victim, which contribute to sadomasochistic object relationships and problems with the regulation of sexual behavior. The repressed or dissociated traumatic memories of sexual abuse carry the potential for producing future psychopathology through displacement in the form of conversion symptoms or somatization, and by generating delayed PTSD when these memories are elicited by current experiences. Anxiety and depression triggered by the emergence of these traumatic memories often lead to alcohol and drug abuse. These substances may be used for their anxiolytic and antidepressant effects.
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PMID:Comparing child victims and adult survivors: clues to the pathogenesis of child sexual abuse. 880 26

Flunitrazepam (Rohypnol) is a benzodiazepine sedative-hypnotic that has generated significant media attention in the United States because of its abuse and its association with "date rape." A field investigation was conducted in south Texas to ascertain the nature and consequences of the abuse of flunitrazepam. In semistructured interviews, 66 subjects identified as flunitrazepam users were asked about their use of alcohol and other drugs and their sexual behaviors. Many subjects identified the drugs they had used as "roches" and gave descriptions of tablets of other benzodiazepines that were not consistent with flunitrazepam. Almost all subjects used other drugs, primarily alcohol and marijuana. Adverse consequences included amnesia, discoordination, automobile accidents, sexual assault, and respiratory depression or arrest. A significant proportion of the subjects reported that continued use was unappealing to them. The abuse of sedative-hypnotics in southeast Texas involves several benzodiazepines and is not limited to flunitrazepam.
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PMID:Abuse of flunitrazepam (Rohypnol) and other benzodiazepines in Austin and south Texas. 881 86

Cigarette smoking may be conceptualized as a strategy to cope with negative affect. Therefore, rates of cigarette use might be expected to be greater in individuals experiencing events that produce negative affect, such as assault. To test this hypothesis, a national sample of 3,006 women aged 18 and older was assessed for lifetime and current cigarette use, previous history of physical and sexual assault, lifetime and current incidence of depression, and lifetime and current incidence of PTSD. Results indicated that the odds of active smoking in women with a lifetime history of assault were 1.82 times those of women with no previous history of assault. Similarly, risk of active cigarette use in women with a previous history of depression or PTSD was 2.22 and 1.34 times those of women with no depressive or PTSD history, respectively. Recent assault, current PTSD, or current depression status were not associated with increased cigarette use.
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PMID:Violent assault, posttraumatic stress disorder, and depression. Risk factors for cigarette use among adult women. 887 12

The purpose of this study was to determine the prevalence of sexual harassment as defined by the AMA among female family practice residents in the United States. Of all 1,802 U.S.FP female resident physicians surveyed, a total of 916, or 51%, completed a survey of which 32% reported unwanted sexual advances, 48% reported use of sexist teaching material, 66% reported favoritism based on gender, 36% reported poor evaluation based on gender, 37% reported malicious gossip, 5.3% reported punitive measures based on gender, and 2.2% reported sexual assault during residency. Thirty two percent of respondents reporting sexual harassment experienced negative effects including poor self-esteem, depression, psychological sequelae requiring therapy, and in some cases, transferring training programs. Sexual harassment is a common occurrence among family practice residents during residency training. Further studies are needed to examine the effect of sexual harassment policies instituted by the American Graduate Council on Medical Education on the prevalence of sexual harassment in medical training since the time of this study.
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PMID:The prevalence of sexual harassment among female family practice residents in the United States. 893 12


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