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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A deficiency of dietary zinc during the suckling period of the rat results in a depression in normal growth, which is, in part, due to the inanition experienced by the dam. The pups from such zinc-deficient dams have smaller forebrains at all of the time intervals investigated in comparison with pups from both zinc-adequate controls. The cell number of the forebrain of the zinc-deficient pup was also reduced in comparison with the zinc-adequate pups. RNA concentration did not appear to be affected, although the total RNA content was reduced because of the smaller brain size. The amount of protein per cell was reduced at 6 and 15 days in the zinc-deficient forebrain and polysomal profiles displayed abnormal distribution of material between monosomes and polysomes in the zinc-deficient brain. Zinc deficiency during the suckling period thus appears to disadvantage the animal in terms of body, brain growth, accretion of cells into the forebrain, and normal protein metabolism.
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PMID:Some effects of postnatal zinc deficiency on developing rat brain. 111 96

The depression of immunity to various antigens in chronic uremia is a frequently encountered phenomenon. Zinc deficiency might well be an important factor in its genesis. The aim of this study was to investigate the role of zinc deficiency in this reduced immune response. Two groups of 7 patients on haemodialysis who had failed to respond with seroconversion to an earlier vaccination against hepatitis B were revaccinated. One group received zinc by the addition of zinc chloride to the dialysate. Before initiation of the study zinc in plasma and leucocytes was measured. No difference in plasma and leucocyte zinc was observed between the two groups. Zinc in leucocytes was lower in patients than in a group of healthy volunteers (61.5 pmol/10E6 cells +/- 4.6 versus 73.8 +/- 5.6, p less than 0.005). Plasma zinc showed no difference between patients and healthy volunteers. During zinc supplementation zinc in plasma rose in the patient group receiving zinc (10.4 mmol/L +/- 1.5 to 14.2 +/- 1.9, p less than 0.005). However, no rise in leucocyte zinc was seen. At the end of the trial seroconversion had occurred in 2 patients in each group. It is concluded that zinc supplementation in haemodialysis patients does not lead to the restoration of leucocyte zinc to normal levels. Neither did it lead to an enhanced antibody response in our population after revaccination of haemodialysis patients against hepatitis B.
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PMID:Effects of zinc supplementation on zinc status and immunity in haemodialysis patients. 182 9

Zinc deficiency was diagnosed in a sheep farm in Khartoum Province; the young sheep and lambs were mostly affected. Skin lesions, depression, wool eating, flexed knees and a markedly stiff gait were observed. Histopathology of the skin revealed mainly hyperkeratosis accompanied sometimes by parakeratosis. The animals responded rapidly to oral administration of zinc oxide.
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PMID:Zinc deficiency in sheep: field cases. 335 59

Zinc deficiency is associated with depression of a number of immune responses. To assess the relationship of zinc and natural killer activity, we studied natural killer activity in adults with sickle cell disease and in two normal volunteers rendered zinc deficient by dietary restriction. Natural killer activity was significantly lower in patients with sickle cell disease and zinc deficiency (5.1 +/- 2.9 lytic units per 10(6) cells) than in controls (11.7 +/- 5.0 lytic units per 10(6) cells). In the two volunteers, natural killer activity declined during zinc restriction and returned to near initial levels with zinc repletion. These results suggest that zinc deficiency is associated with a lowering of natural killer activity.
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PMID:Decreased natural killer cell activity in patients with zinc deficiency with sickle cell disease. 396 62

1. Zinc deficiency was studied in mice infected with Trypanosoma musculi. 2. In all dietary groups, the infected animals consumed more food and gained more weight than the uninfected controls. 3. In all studies, at the peak of parasitemia, the zinc-deficient animals showed three times the number of trypanosomes as that of the complete and pair-fed mice. 4. The average coefficients of variation in body lengths of T.musculi cells indicated that the formation of the reproductive-inhibiting antibody (ablastin) occurred later in zinc-deficient animals compared to animals fed complete diets. The degree and duration of parasitemia in the zinc-deficient animals indicated a delay in the synthesis of the terminal lytic antibody. 5. Irrespective of diets, severe depression in the primary and secondary antibody responses to in vivo immunization of sheep erythrocytes was observed in infected animals over non-infected controls.
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PMID:Interaction of nutrition and infection: effect of zinc deficiency on resistance to Trypanosoma musculi. 634 33

Zinc deficiency was diagnosed in 2 flocks of sheep and a herd of goats. Alopecia and eating of wool were observed. Skin lesions were hyperkeratosis and parakeratosis. Abnormal hoof growth and a closed stance with arched back and bowed hindlimbs were seen. Anorexia, depression, and foot soreness diminished quickly after zinc supplementation. Skin lesions healed and hair and wool growth resumed. A cause for the deficiency could not be established.
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PMID:Zinc deficiency in sheep and goats: three field cases. 673 71

Zinc deficiency was produced experimentally in guinea-pigs fed on a diet containing 1.03 mg Zn/kg over a period of 45 days. Clinical signs exhibited in Zn-deficient (ZnD) animals were depression with abnormal posture, scaly skin lesions on various parts of the body, oedematous swelling on hind limbs and marked alopecia. There was no effect on food intake. Serum studies in ZnD group revealed significant decreases in the concentrations of Zn from 20 days onwards, and tri-iodo-thyronine (T3) and thyroxine (T4) from 30 days onwards. Thyroid glands of ZnD animals were smaller in size and pale or whitish pale in colour. Histopathologically, these glands showed changes of atrophy and degeneration in the follicles. It could be concluded that the depletion in serum T3 and T4 due to Zn deficiency was related to thyroid lesions.
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PMID:Effect of experimental zinc deficiency on thyroid gland in guinea-pigs. 949 Nov 94

Zinc (Zn2+) is an elementary ion which plays a fundamental role in a wide range of biological processes. Zinc is an essential component of various proteins and is an important modulator in the mammalian central nervous system (CNS). In CNS, zinc is found at high concentrations in hippocampal and cortical neurons. These neurons possess mechanisms for Zn2+ uptake and storage in synaptic terminals, and stimulation release Zn2+ ions along with neurotransmitters. Zn2+ modulates predominantly the excitatory (glutamatergic) and inhibitory (GABA ergic) amino acid neurotransmission pathways in CNS. Zinc deficiency impairs neuro- and immunoactivity of the mammalian organisms. In the present paper, alterations in the blood and brain zinc concentration in relation to depression and the mechanism of antidepressant therapy are discussed.
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PMID:Alterations in zinc homeostasis in depression and antidepressant therapy. 966 32

Zinc deficiency is not an uncommon nutritional disorder in the elderly. It should be suspected in patients who have conditions associated with zinc deficiency (Table 1) or who have one of the potential causes of zinc deficiency (Table 2). A low serum-zinc level indicates zinc deficiency unless an acute phase response is present. The acute-phase response should be suspected in a patient with an acute illness. A C-reactive protein level is helpful in identifying the acute-phase response. Our initial treatment of zinc deficiency centers on increasing dietary zinc. Often, however, because of other common problems of geriatric patients such as dementia or depression, the patient is unable to alter his or her diet. Then, zinc supplementation may be required. Copper, iron, and lipoprotein status should be monitored if long-term zinc supplementation is needed because they may be effected by the zinc supplementation.
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PMID:Case report of zinc deficiency in an elderly woman. 1015 Apr 66

Studies have shown that there is a relationship between zinc levels and depression. Thalassemic patients are at risk of zinc deficiency due to various causes including Desferal injection. The aim of this study, therefore, is to investigate hair zinc levels in thalassemic patients and their association with depression. For the purposes of this survey, 50 patients with major thalassemia between 10-20 years old were selected randomly. The patients' hair zinc concentration was compared with a control group of similarly aged healthy individuals. Simultaneously, their psychological status was evaluated with either the "Beck" or "Marya Kovacs" test (according to age) so that the relation between depression and zinc concentration could be assessed. The mean hair zinc concentration in patients was more than the controls (193.96 +/- 92.4 ppm vs 149.6 +/- 72.21 ppm). Zinc deficiency was present in 10% of the patients, and 52% had some degree of depression. There was a reverse correlation between zinc deficiency and blood transfusion rate (p < 0.05). Also, while there were more incidences of depression among the zinc deficient patients, the difference was not significant. Regarding the high prevalence of depression and insignificant relation to the zinc deficiency in these thalassemic patients, this research suggests the need for further consideration concerning patients' psychological status, the risk factors of zinc deficiency, as well as extended assessment into other causes of depression.
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PMID:Zinc in thalassemic patients and its relation with depression. 1833 12


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