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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hyponatremia with simultaneous renal sodium loss was associated with the inappropriate secretion of antidiuretic hormone in a dog with heartworm disease. Antidiuresis caused expansion of extracellular fluid volume, which induced renal salt wasting and a negative sodium balance. The combination of water retention, salt wasting, and inactivation of intracellular solute contributes to the decrease in serum sodium concentration. Water intoxication due to hypotonicity of body gluids induced anorexia, depression, weakness, and incoordination.
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PMID:Inappropriate secretion of antidiuretic hormone in a dog. 50 Apr 39

In 12 patients with coronary artery disease and typical exercise-induced angina pectoris hemodynamic and ECG studies were performed at rest and during ergometer load in supine position. During the attacks of angina there was a significant ST-depression in all cases accompanied by elevated pulmonary capillary wedge pressures (PCP) and pulmonary artery mean pressures (PAM). Intravenous administration of 40 mg furosemide showed consistent hemodynamic changes. Cardiac output (CO) dropped significantly by 15.9 per cent at rest (p is less than 0.001) and by 6.9 per cent during exercise (p is less than 0.005). The PCP during exercise following furosemide decreased from 32.9 mmHg to 11.8 mm Hg (p is less than 0.001) and was paralleled by a significant decrease of PAM, indicating reduction of ischemia-related hemodynamic impairment. Furthermore, there was a striking improvement of Ecg findings during ergometer load in 9 of 12 patients as well as a relief of anginal pain in 11 of 12 patients. The present demonstration of antianginal properties of furosemide may be explained by the reduction of ventricular volumes and pressures, resulting in a decrease of myocardial wall stress. These effects are suggested to be related to the peripheral venodilator capacity of furosemide in conjunction with its diuretic properties. Thus, in patients with left ventricular dysfunction secondary to ischemia, intravenous furosemide may have salutary effects on myocardial oxygen requirements resembling the action of nitroglycerin, but without its oxygen-wasting effects on tachycardia.
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PMID:[Effects of furosemide on hemodynamic, electrocardiographic, and symptomatic responses to exercise in patients with angina pectoris (author's transl)]. 63 18

A mortality in muscovy ducklings caused by infection with the intestinal fluke, S. globulus, is described. The disease was characterised by depression, anorexia, wasting, diarrhoea and high mortality. The major pathological lesions were associated with the attachment sites of the flukes and consisted of severe enteritis with ulceration, principally affecting the jejunum, but also involving the duodenum and ileum. Experimental infections were produced in ducklings by oral administration of either G. austrialis infected with S. globulus metacercariae or S. globulus metacercariae or S. globulus metacercariae. The small, dextral, operculate snail G. australis was identified as the intermediate host and G. australis and an unidentified planorbid as transport hosts. L. tomentosa was also able to be a transport host. The epidemiology of the outbreak and aspects of acquired resistance are presented.
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PMID:The occurrence of the intestinal fluke Sphaeridiotrema globulus in domestic ducks in New South Wales. 84 14

Defective potassium excretion with clinical acidosis, associated with fixed moderate sodium wasting, has been found to be a common abnormality in lead nephropathy. Lead poisoning has been shown by others to be associated with depression of the renin-aldosterone system and of sodium and potassium activated adenosinetriphosphatase (ATPase). Since these hormonal defects may contribute to the hyperkalemia and are reversible, lead poisoning should be treated aggressively. Management also requires proper regulation of dietary sodium, correction of acidosis, limitation of dietary potassium, and minimal use of antihypertensive agents, as well as the administration of allopurinal for urate control.
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PMID:Hyperkalemia and acidosis in lead nephropathy. 94 Oct 56

The identification of marginal magnesium deficit, such as we have detected in a patient with anxiety, depression, and psychomatic complaints, is a difficult diagnostic problem. Electromyography of a limb, rendered acutely ischemic either just before or after hyperventilation, can elicit latent tetany in this condition, as well as in calcium deficiency. We have demonstrated iterative electrical activity in our patient, whose magnesium deficit is attributable to renal wasting of magnesium. We have elicited similar patterns in several other patients, who had marginally low serum magnesium and who also exhibited weakness, anxiety, and psychosomatic disorders. This preliminary report suggests the need for further consideration of the possibility that chronic magnesium-deficit may contribute to the syndrome of latent tetany, psychosomatic complaints, and weakness.
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PMID:Latent tetany and anxiety, marginal magnesium deficit, and normocalcemia. 116 68

Polymyalgia rheumatica should be considered when a syndrome of constitutional symptoms, especially weight loss, low-grade fever, weakness, wasting proximal muscles, fatigue, malaise and depression, is seen in the elderly. Giant-cell arteritis plays a part later in the course. Thus the need for biopsy of a long segment of the temporal artery to help in determining diagnosis and therapy. An elevated erythrocyte sedimentation rate (ESR) is an important clue. The usual high value is about 80 mm/hour; if it is over 100 mm/hour, giant-cell arteritis should be suspected. Salicylates, indomethacin, phenylbutazone and hydroxychloroquine produce some clinical improvement but do not lower the high ESR; moreover, the patients are prone to experience relapses. Prednisone, however, not only produces clinical improvement but lowers the high ESR. Potassium p-aminobenzoate may be useful in maintaining the remission.
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PMID:Polymyalgia rheumatica. 124 88

To test for oxygen wasting by norepinephrine (NE) without relying on normalization by measures of performance such as the pressure-volume area, myocardial oxygen consumption (MVO2) was determined for isovolumic beats at five different left ventricular (LV) end-diastolic volumes (EDV) in nine isolated cross-perfused canine hearts in each of three states: a basal anesthetic state (B); after depression with halothane (H); and after adding NE to increase contractility back to the B state (H+NE). The end-diastolic and peak systolic pressure-volume lines were identical for B and H+NE. The R2 for a linear regression of MVO2 per beat for B vs. H+NE for beats originating at the same EDV and developing similar (within 10%) peak isovolumic pressures for all hearts was 0.85. The slope and intercept were 0.83 and 0.01, which are significantly less than one (P less than 0.001) and greater than zero (P less than 0.001), respectively. These data suggest that NE increases both the economy of pressure development as well as activation energy of an isovolumically contracting LV.
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PMID:Norepinephrine increases the economy of pressure development in isolated canine hearts. 141 95

During this experimental work, we studied the immunological recuperation in CD1 mice in whom a weakening disease was induced using intraperitoneal injections of a sterile mixture of dead staphylococci. After a deep depression of the synthesis of anti-sheep red blood cell antibodies (SRBC) during the following 10 days after the induction of wasting, the animals regained their capability to produce anti-SRBC antibodies, significantly increasing. Two weeks after the injections were applied, the average number of antibody producing cells rose significantly and even doubled in the control group of healthy mice. Finally, after two weeks after this "rebound", the number of antibody forming cells return to normality. The article includes a discussion on the biological significance of this carried out in experimental animals while offering a hope for children with secondary immunological deficiencies or for those with repeatedly severe infections.
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PMID:[Induction and recovery of immunologic weakening]. 195 76

To characterize type and age distribution of malnutrition and to determine the usefulness of anthropometric indices in children with chronic liver disease (CLD), 56 children (aged 1 mo-10 y) with CLD underwent anthropometric evaluation when they were clinically stable. Mean-height Z score was depressed, whereas mean-weight Z score was closer to normal and mean-weight/height Z score was normal in patients with extrahepatic biliary atresia, idiopathic neonatal hepatitis, and other liver disorders. Patients with arteriohepatic dysplasia showed more severe depression of all three variables. In all patients, triceps skinfold (TSF) thickness Z scores were significantly more depressed than were weight/height Z scores. Depressions of midarm-circumference and midarm-muscle-area Z scores were intermediate. Mean-head-circumference Z score was depressed in children aged less than 24 mo. We conclude that acute (wasting) and chronic (stunting) malnutrition are common in childhood CLD and that weight/height values underestimate the degree of acute malnutrition compared with TSF thickness, most likely because of the inflated patient weight caused by organomegaly.
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PMID:Anthropometric evaluation of children with chronic liver disease. 237 85

The plasma concentrations of cortisol and corticosteroid-binding globulin and the adrenal synthesis capacity of cortisol were analysed in 10-week-old healthy and age-matched wasting or unthrifty pigs. Crypt cell multiplication, villus height and intestinal mucosal alkaline phosphatase (ALP) activity were also investigated. Furthermore, the effect of amperozide, a psychotropic drug with specific effects on emotional behaviour, was analysed for its effect on plasma ALP activity and villus height. Although the wasting pigs exhibited an increased cortisol synthesis capacity, there was a decreased plasma concentration of cortisol in these pigs. Furthermore, the plasma cortisol binding capacity was found to be significantly lowered in wasting pigs. There was also a reduced crypt cell proliferation, a reduced villus height and a decreased ALP activity in the ileal mucosa. Treatment with amperozide resulted in a normalisation of plasma ALP activity in unthrifty pigs, indicating a stimulation of body growth. The results indicate that the growth depression of wasting pigs is most probably a chronic stress syndrome caused by the inability of these animals to cope with the events following weaning and mixing.
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PMID:Subclinical characteristics of the wasting pig syndrome. 238 58


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