Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient with acquired immunodeficiency syndrome (AIDS) who required aggressive nutritional intervention via home parenteral nutrition therapy is described, and nutritional status, etiology and therapeutic management of AIDS-associated malnutrition, role of nutrition support, and factors for consideration in using parenteral nutrition in AIDS patients are discussed. Parenteral nutrition therapy was initiated in a 30-year-old AIDS patient with Kaposi's sarcoma lesions of the gastrointestinal tract because of rapid weight loss, low serum protein levels, and malnutrition. He had previously undergone a small-bowel resection and a jejunojejunostomy, and radiation and antineoplastic-drug therapy was planned. During parenteral nutrition therapy, the patient demonstrated increased physical strength and was able to care for himself during most of the time spent at home or in a long-term-care facility. Aggressive measures, including parenteral nutrition therapy, were discontinued 11 days before the patient's death. Complications of therapy included one episode of sepsis and a tear in the external catheter tubing. Malabsorption and diarrhea mainly caused by gastrointestinal disease, reduced food intake because of oral and esophageal infections, adverse effects from medication, and depression are factors that can contribute to AIDS-associated malnutrition. Also, hypermetabolism resulting from infections and fevers may contribute to malnutrition in AIDS. The extent to which this malnutrition affects the underlying immune dysfunction occurring in the syndrome and the response to other more direct drug therapies in AIDS is not known. Available methods for nutritional intervention are based on clinical experience and anecdotal reports. Because of gastrointestinal disease, an oral diet, supplements, and enteral tube feedings may not meet nutritional goals for an AIDS patient.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Parenteral nutrition in the management of gastrointestinal Kaposi's sarcoma in a patient with AIDS. 313 64

We have studied the prevalence of mental disorder in a variety of patients with head and neck cancer in different stages of disease and treatment. All together, 59 patients were studied according to a comprehensive psychopathologic rating score and nutritional status. Six patients refused to answer the comprehensive psychopathologic rating score questionnaire. Of the remaining 53 patients, 13 patients were classified as mentally disordered. Five patients were classified as mentally depressed according to a specific comprehensive psychopathologic rating scale depression score. We found that depression was significantly linked to malnutrition. In total, 30% of our patients with cancer with weight loss demonstrated features that were consonant with depression. This suggests that mental depression is associated with physical improvement rather than with the malignant condition per se.
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PMID:Mental depression is associated with malnutrition in patients with head and neck cancer. 319 Aug 74

The influence of dietary protein on the efficiency with which mice could be immunized against infection with the nematode Heligomosomoides polygyrus was investigated. Immunization with irradiated larvae did not protect outbred mice fed synthetic diets containing 2% or 4% protein against a challenge infection, while animals fed a diet containing 8% protein were significantly resistant. In further experiments with high-responder NIH mice, protein malnutrition was again found to cause a significant depression in immunity. Immunization primed all mice for an intense production of antibody against larval worms in a challenge infection, and although a slightly higher titre of antibody was detected in the plasma of mice fed a 16% compared with a 2% protein diet it seemed unlikely that this was sufficient to account for the reduced resistance of the malnourished mice. The development of eosinophilia in the blood of immunized mice was significantly delayed in malnourished animals following challenge, and it is suggested that a reduction in the number of granulocytes attacking larval worms contributed to the low level of resistance observed in these animals. Protein malnutrition thus markedly suppresses the effectiveness of immunization of mice against an intestinal nematode, and it is suggested that this result may be of general significance with regard to the potential for widespread immunization of people against infections of this type.
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PMID:The influence of protein deficiency on immunity to Heligmosomoides polygyrus (Nematoda) in mice. 319 48

The following list is presented as a summary of guidelines that may be helpful in the investigation of a nutritional disorder. 1. Identify the perceived herd or flock problem. The client's complaint usually reflects an appearance of clinical signs or a depression in production parameters. The practitioner should also identify subclinical manifestations and other concurrent problems. 2. Identify the affected population or subpopulation. Groups should be identified according to breed, sex, age, reproductive status, growth phase, and lactation status. It is critical to identify the affected population, as a diet can be adequate for one population and deficient or excessive for another. For example, 24-month-old Angus heifers in the first 60 days of lactation would have greater risk of protein-energy malnutrition than would 5-year-old Angus cows in their second trimester of gestation if both were fed a marginal hay ration. 3. Identify the nutritional requirements for the affected population. The National Research Council publications serve as a guideline in determining nutrient requirements. 4. Identify factors that influence nutrient requirements and feed intake. Environmental factors, such as ambient temperature, can affect both nutrient requirements and feed intake of the population. Housing conditions, such as muddy lots, can increase maintenance requirements. 5. Sample and evaluate the feedstuffs. Nutrient(s) must be bioavailable--that is, they must be in a form that can be ingested, digested, and absorbed by the animal. 6. Sample and evaluate water sources for quantity and quality. 7. Evaluate feed bunk management practices. 8. Examine the herd. Both affected and normal populations should be examined. 9. Evaluate and submit to a laboratory any animal samples that may relate to the disorder. 10. Assemble the data and develop a hypothesis to support a diagnosis. 11. Provide a written account of all recommendations for the producer.
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PMID:The investigation of nutritional disorders. 325 54

Depression of cell-mediated immunity is well established in most malignancies and especially in head and neck cancers, and much information is available concerning the defect in helper T lymphocyte function. We now report on impairment of the monocyte-macrophage system. Compared with normal controls we found that patients displayed, on one hand, an increased number of peripheral blood monocytes and, on the other hand, a smaller percentage of HLA-DR+ monocytes. Such peripheral blood monocytes normally failed to secrete factors, including interleukin 1 (IL-1). In addition, we observed that the in vivo induced blastogenesis of peripheral blood lymphocytes from patients, which is spontaneously depressed, is partly restored by medium containing IL-1. We cannot exclude, however, that the observed monocyte dysfunction involves other cytokines. Whether such an immune deficiency is due to secondary malnutrition or to the malignancy (or both) remains unclear.
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PMID:Impairment of monocyte functions in advanced head and neck cancer. 326 77

Nutritional deficiencies are believed to be instrumental in producing reduced immune responses in a variety of animal species. Malnutrition may result in an increase or a decrease in immune functions, depending upon its degree, and also the timing and severity of the nutritional protein deprivation. Our experimental data suggest that there is a significant impairment of cytotoxic activity against K-562 and of the ability of spleen cells to produce interferon in protein-deprived mice in comparison with control mice. Paradoxically accelerated tumor growth after administration of OK-432 or Lentinan was also noted in protein-deficient tumor-bearing mice. In addition, a clinical randomized study of advanced or recurrent gastric cancer patients treated with MMC and FT(MF) with or without lentinan was performed. We recognized excellent end-point results only in the lentinan-treated patients with normal protein levels, while no effect of this agent was seen in patients with low serum protein levels (below 5.9/dl). Aggressive postoperative chemotherapy for cases with distant lymph node metastasis was performed under active nutritional support without any depression of metabolic and immunological states, resulting in a good 5-year survival rate (36.9%).
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PMID:[Anti-cancer effects of BRMs associated with nutrition in cancer patients]. 338 33

Mortality occurs from a burn injury because of infections which result from the metabolic and bacterial consequences of a large open wound, depression of the host's resistance, and both protein and total caloric malnutrition. Systemic antibiotics, topical wound therapy, and gentle wound debridement constitute traditional burn therapy. The systemic antibiotics and topical wound therapy do not solve problems presented by large open wounds and the related protein and caloric deprivation. A more rational approach uses antibiotics and topical wound therapy only as adjuncts to a program of early operative removal or excision of the devitalized, burned tissue and immediate closure of the wound. The excised wound is normally closed with available autograft, but in massive burn injuries, donor skin is insufficient. In these massive injuries, artificial skin can provide that immediate wound closure. As long as devitalized, burned tissue remains present in the setting of depressed host resistance, cross infection tends to colonize those remaining devitalized burn wounds with more virulent organisms than those that were already present. Bacterial controlled nursing units (BCNU) provide strict protection against that cross infection. Though inevitably a catabolic response occurs with massive injury, intensive nutritional support provides the calories necessary for the response to injury to avoid a prolongation of that negative nitrogen balance.
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PMID:Burn therapy 1985: acute management. 353 Dec 77

The effects of food restriction or 20 ppm NO2 exposure on humoral immunity were investigated in normal and adrenalectomized C57Bl/6 mice. The thymic and splenic weights of sham-operated mice were similarly diminished after 4 days of NO2 exposure or 4 days of food depletion. The responses of corresponding adrenalectomized mice were less depressed. Undernutrition induced lymphoid organ involution and corticosteroids were partly involved. Plaque-forming cells (PFC) per spleen and per 10(6) cells were markedly depressed after 4 days of NO2 exposure, but less so after food deprivation. The same significant suppression of PFC was observed in adrenalectomized groups. Depression of humoral immunity was independent of stress-induced endogenous steroids. Moreover, NO2 had a specific effect on humoral immunodepression, food restriction being an associated factor.
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PMID:Evidence for humoral immunodepression in NO2-exposed mice: influence of food restriction and stress. 356 84

Phenobarbital appears to produce similar behavioral effects on mice and humans with excitation at low and sedation or depression at higher doses. If plasma concentrations of phenobarbital reflect levels in other tissue, then brain concentrations producing excitation (near 10 micrograms/g) and depression (near 20 micrograms/g) are not substantially different for the two species. The doses needed to produce these levels are much higher in mice than man. Plasma concentrations of phenobarbital decline during pregnancy in humans. Whether this decline is accompanied by increased seizure frequency has not been confirmed empirically and whether pregnancy influences the frequency of seizures at all is controversial. The reduction in phenobarbital levels in plasma or serum during pregnancy has been confirmed in rodents. Two of these studies however reported no difference brain concentrations of the drug during pregnancy. One study indicated increased potency of the drug, however this was not confirmed by the other two reports. The effects of phenobarbital on the progression of pregnancy and on offspring is not well defined in humans partly because the disease and the treatment effects are confounded. There are a few studies however which suggest that the effects might be drug specific. Animal studies in this area differ substantially from humans in design making any comparison tentative. The effects of the drug on pregnancy and neonates in rodents depends on the method of administering the drug and dose. Drug administration via the diet can provide high blood levels in the dams and causes lowered birthweight as well as several anatomical and hormonal abnormalities in offspring. This procedure, however, also severely reduced food intake and weight gains during pregnancy which might confound drug effects with nutritional deficiency. The drug can be injected in doses which produce plasma levels well within the therapeutic range for humans. Under these conditions the drug is less detrimental to the progression of pregnancy, however, the higher doses can increase neonatal mortality and reduce body weight of surviving offspring. Although mortality and body weight are not adversely effected by lower doses, changes are still apparent in the behavior as well as several biochemical parameters. Fostering studies on animals suggest that the effects of maternal injections of phenobarbital on offspring are due to the IN UTERO exposure rather than postnatal maternal factors and that effects produced by fostering itself may be confounded with the drug effects.
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PMID:Phenobarbital during pregnancy in mouse and man. 378 54

Inpatient geriatric consultation services have the potential for educating large numbers of health professionals and influencing the clinical care of large numbers of patients. Such consultation can identify new diagnoses and recommend treatment of conditions whose appropriate management can improve patients' functional level. At San Francisco General Hospital, the most frequent recommendations were medication adjustment, management of dementia, delirium or depression, rehabilitation, and treatment of malnutrition. Of 35 patients slated to go to nursing homes at the time of consultation, 18 were rerouted to lower levels of care, and 14 eventually went home. Preliminary findings at the Palo Alto Veterans Administration Medical Center replicate these data.
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PMID:Inpatient geriatric consultation. 381 44


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