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Query: UMLS:C0011570 (depression)
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Two questionnaires totalling 370 questions were used to compare 61 male patients who had survived a first myocardial infarction with a group controlled for age and social status who had not had an infarction. The questionnaires included the Edwards Personal Preference Schedule, providing a measure of 15 personality variables, the Anxiety and Depression Sub-Scales of the MMPI, and the Cochrane and Robertson Life Events Inventory, as well as originally-designed questions based on known risk factors. Significant differences were found in several dimensions of personality as well as in the family histories of myocardial infarction and in certain life styles. The patient group showed a greater sense of independence, greater difficulty in relaxing, and a sence of personal inferiority. Suggestions are offered for the modification of life styles in susceptible individuals as a possible aid to prevention.
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PMID:Psychosocial factors and myocardial infarction. 26 28

Fifty-eight women, desiring to lose at least 45 kg, participated in a diet group and completed a battery of personality inventories. Their scores differed significantly from normative data on several subscales of the personality inventories. As a group, these extremely obese women scored low on the Tennessee self-concept scales, particularly on the physical self-concept scale. On the Edwards personal preference schedule, they scored low on the deference, order, affiliation, nurturance, and endurance scales, and high on the dominance and heterosexuality scales. On the Minnesota multiphasic personality inventory, they scored high on the depression, hysteria, psychopathic deviate, and paranoia scales, and they scored low on the masculinity-feminity scale. The most striking finding was that these extremely obese women, who were not alcoholics, showed scores on alcoholism scales which are typical of an alcoholic population.
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PMID:Psychosocial aspects of extremely obese women joining a diet group. 52 27

Several researchers have found anxiety and depression to be indistinguishable in nonclinical samples and have suggested that both constructs may be components of a general psychological distress process. Another possibility is that overlap is due to the psychometric limitations of scales used. A series of exploratory factor analyses were conducted in a nonclinical sample (N = 605) using the Beck Depression Inventory (BDI; Beck, 1978), the State-Trait Anxiety Inventory (STAI; Spielberger, 1983), and the Endler Multidimensional Anxiety Scales (EMAS; Endler, Edwards, & Vitelli, 1991). Both state and trait anxiety and depression could be differentiated with the BDI and the EMAS but not with the STAI. Some theoretical models of negative affectivity or general psychopathology may be premature.
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PMID:Self-reports of depression and state-trait anxiety: evidence for differential assessment. 144 95

The purpose of our study was to reanalyze the Depressive Experiences Questionnaire (DEQ; Blatt, D'Afflitti, & Quinlan, 1976, 1979) and to evaluate relationships between the questionnaire's factors and other construct-related measures, the Beck Depression Inventory (Beck, Ward, Mendelson, Mock, & Erbaugh, 1961) and the Edwards Personal Preference Schedule (Edwards, 1959). We argue that composite scores derived from this study's principal components analysis are more interpretively useful than the original factor scales reported by Blatt et al. (1976; Blatt, Quinlan, Chevron, McDonald, & Zuroff, 1982). Correlational evidence reported in this study does not support the Dependency and Self-Criticism factors as adequate representations of anaclitic and introjective depression (Blatt, 1974). The third DEQ factor scale, Efficacy, as revised for this study, demonstrated moderate to strong associations with other personality measures.
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PMID:Subtypes of depression, efficacy, and the Depressive Experiences Questionnaire. 149 63

In a previous paper (Rake and Edwards, 1987) it was shown that the majority of the chromatin from trisomic mouse cells has nucleosomes with a smaller repeat length of DNA than the nucleosome repeat length of normal cells. Here it is shown that the RNA content of the total cell and of the nuclei is the same in all tissues studied, in both normal and trisomic cells. However, the amount per unit time or rate of RNA synthesis is depressed in the trisomic liver and brain nuclei. The depression of RNA synthesis could not be specified to the small trisomic section of the chromatin but instead must reflect the overall nuclear activity. These results, along with those of Devlin et al. (1988), indicate that the trisomic condition alters a substantial part of nuclear organization and activity, not just the small trisomic part.
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PMID:Effect of a partial trisomy in the mouse upon cellular and nuclear RNA. 248 29

34 patients scheduled for coronary artery bypass graft (CABG) surgery were studied during postoperative period. Right ventricular performance was specially performed with use of cardiac output computer REF-1 Edwards Lab., before Anaesthesia (T1) and at 6 investigation times after surgery during and after mechanical ventilation. The sixth first postoperative hours were marked by a decrease of cardiac index (2.56 +/- 0.4 to 2.41 +/- 0.41.mn-1.m2) and right Ventricular Ejection Fraction (RVEF) (0.48 +/- 0.07 to 0.37 +/- 0.09). The second period was the weaning period with a further drop of RVEF (0.43 +/- 0.1 to 0.36 +/- 0.07) without change in cardiac index (2.80 +/- 0.51.mn-1.m2, suggesting a ventricular post-operative and weaning depression, as previously described for the left ventricle. In addition, postoperative tachycardia (Heart rate = 59 +/- 9 at T1 to 95 +/- 14 at T7) may contribute to myocardial ischemia.
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PMID:Evolution of right ventricular performance after CABG. 326 4

The relationship between psychiatric disorder (as measured by severity of psychoneurotic status and depression) and decision-making behaviour was examined in a sample of 39 hospitalised patients. Measures based on the conflict theory of decision-making of Janis and Mann (1977) and the expectancy-value theory of decision-making of Edwards (1961) were administered. Patients who scored highest on measures of psychoneurotic disorder--the Middlesex Hospital Questionnaire and the Beck Depression Inventory--were least confident about their decision-making. They also reported a high use of maladaptive decision-making coping patterns, in particular decision avoidance. Slightly over one-half of the patients demonstrated an ability to make rational decisions, while the remainder made either irrational decisions or avoided making any decision at all. Observation in the test session revealed that patients were strikingly slow in answering the questionnaires and often attempted to make no response. The importance of this area of research for patient assessment and treatment is discussed.
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PMID:Psychiatric disturbance and decision-making. 346 65

A sample of 23 veterans entering the Pathological Gambling Treatment Program at the Veterans Administration Medical Center in Miami, Florida, were administered a battery of tests including the following: Wechsler Adult Intelligence Scale (WAIS), Minnesota Multiphasic Personality Inventory (MMPI), Edwards Personal Preference Schedule (EPPS), and the Personal Orientation Inventory (POI). Findings on the intelligence testing indicated that on the average the pathological gamblers were of bright normal intelligence with a mean WAIS Full Scale IQ of 116.78, mean Verbal IQ of 119.30, and a mean Performance IQ of 111.30. Group profile results on the MMPI showed significant mean clinical scale elevations on two of the nine clinical scales: Scale 2, Depression; and Scale 4, Psychopathic Deviate. Group profile results on the EPPS indicated relatively high scores on the variables of achievement, exhibition, autonomy, dominance, and heterosexuality; and relatively low scores on the variables of deference, order, and endurance. Group profile results on the POI were essentially within normal limits with a tendency toward time incompetency noted, suggesting difficulty living fully in the present here and now.
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PMID:Psychological test findings on pathological gamblers in treatment. 664 93

The 18th human chromosome is probably known mainly due to patients with Edwards syndrome, children dying usually during the first week of life, the syndrome being due to the presence of three chromosomes 18-trisomy. Some of its loci participate in oncogenesis either as cellular oncogenes (BCL2 in lymphomas), or antioncogenes (DCC--in colorectal carcinomas--Lynch I and Lynch II). It is assumed that some of the causes of maniac depression could be associated with chromosome no. 18.
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PMID:[The human genome--chromosome 18]. 748 75

This is a story by a woman about her life with panic, agoraphobia, and depression. She tells us about the clinical features, the heritable components, the environmental contributions, the developmental penalties, the social consequences, and the therapies for these conditions far more vividly than even the most dramatic of our systematic studies. But this is more than a clinical vignette. It is a human story of courage to proceed undaunted in the face of terror and despair to ultimately prevail over the most formidable internal obstacles. Nowadays I rarely see Mrs. Edwards. She is too busy living. I know she is productively and gratifyingly employed and engaged with her family. Usually I learn of her adventures here and abroad through letters written in the same captivating style as the autobiography below. I have witnessed Mrs. Edwards reading her story to others with similar problems, to medical students, and to psychiatric residents. The impact invariably was stunning. Making her acquaintance even in the dry print medium is an unforgettable learning experience.
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PMID:Panic disorder and agoraphobia: a sufferer's perspective. 971 83


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