Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors have examined all of the hospitalized patients who were over sixty years old in all psychiatric clinics in Gifu Prefecture, Japan, on December 31, 1968, and many of them were reexamined on June 30, 1973. Through these both serial examinations, the following results are obtained: 1) Of the total 187 patients who underwent the first examination, 62 patients were still hospitalized and subjected to the second examination. 2) Twenty nine of the 62 patients were schizophrenics. One fourth of them were in remission, the rest being in a desolate or paraphrenic condition. Thirty six schizophrenics have discharged hospitals: 12 patients have left off hospitals getting a considerable improvement and 15 patients were dead. 3) Of the thirteen manic-depressives, only three were still hospitalized, and two of them were in remission. There were 10 discharged cases: three cases dead and six cases improved. 4) Six of the 24 patients diagnosed as senile dementia were still hospitalized. The diagnosis of two cases has been changed into paranoid reaction and depression respectively. Of 18 discharged patients, 14 cases were dead and the remaining four were improved. 5) Of the 22 patients diagnosed as senile psychosis, only two patients were still hospitalized, and the diagnosis has been changed into schizophrenia and epilepsy respectively. The 20 patients have left hospitals: nine cases dead and another nine improved. As the beginning symptoms, these patients showed paranoid-hallucinatic aspects which were similar to those of schizophrenia. In some cases, certain incidents that had preceded onset of the illness were found. 6) Most of the aged patients with the diagnoses associated with the physical conditions due to aging were dead.
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PMID:[Disease course and outcome in hospitalized patients over 60-years old]. 117 73

In two years of clinical practice, the authors saw 47 cases of gonorrhoea of strictly psychological origin--25 patients with anxiety neurosis, 10 with hypochondriasis, 7 with depression, and 5 with paranoid reaction, 25 with impotence initially presented for surgical opinion rather than psychiatric assessment. Socio-demographic factors and 4 clinical details are given, including possible related factors, course, treatment and outcome. Liaison between the veneorologists, surgeons and psychiatrists is strongly advocated.
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PMID:Gonorrhoea neurosis. 139 16

The abrupt appearance of clozapine discontinuation symptoms represents a particularly unique situation that has not been characterized in a double-blind, placebo-controlled trial. A randomized, double-blind comparison of placebo (N = 53) and olanzapine 10 mg (N = 53) for 3 to 5 days following the abrupt discontinuation of clozapine (< 300 mg/day) was carried out. Subjects were assessed with the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression Scale of Severity, the Montgomery-Asberg Depression Rating Scale (MADRS), and the Mini-Mental State Evaluation. Subsequently both groups received open-label olanzapine (10-25 mg/day) for an additional 9 weeks. Statistically significantly more placebo-treated (24.5%) than olanzapine-treated (7.5%) patients experienced clozapine discontinuation symptoms (p = 0.017). Core symptoms included delusions, hallucinations, hostility, and paranoid reaction and translated into a significantly higher worsening from baseline on the PANSS total, PANSS General Psychopathology subscale, and MADRS among subjects randomly assigned to receive placebo. After open-label treatment with olanzapine for 9 weeks, both groups were clinically stable, suggesting that the discontinuation symptoms were transient. However, subjects who had been randomly assigned to the 3- to 5-day placebo discontinuation segment achieved somewhat less global clinical improvement. Although a pharmacologic interpretation is speculative, evidence of a clozapine discontinuation syndrome was apparent. In most cases, the direct substitution of a pharmacologically similar agent (olanzapine) prevented the syndrome. Clozapine discontinuation or noncompliance should be considered in the differential assessment of an acutely emergent psychosis. The possibility that subjects who experience a clozapine discontinuation syndrome may take longer or are less likely to clinically restabilize warrants further investigation.
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PMID:Controlled, double-blind investigation of the clozapine discontinuation symptoms with conversion to either olanzapine or placebo. The Collaborative Crossover Study Group. 1050 85