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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Suicide is more common among the elderly than any other age group. Elderly white males constitute the group at highest risk for suicide in the United States. Older persons typically choose means of high lethality in suicide attempts. Previous suicide attempts, bereavement, alcohol abuse, depression, psychosis, physical illness, and social isolation are all risk factors for suicide in the elderly. Clinicians who treat this patient group should have a high index of suspicion for suicidal ideation.
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PMID:Suicide in the elderly. 235 47

Thirteen famous writers who completed suicide during this Century were analyzed for common themes in their lives. Affective disorder and depression were found to be common. In addition, alcohol abuse was present in about a third of the writers. For six of them, the possibility of being unable to continue to write productively played a role in their depression and eventual suicide.
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PMID:An analysis of poets and novelists who completed suicide. 236 41

Depression and alcohol abuse have been associated with alterations in cell-mediated immune function. This study directly compared the effects of depression, alcoholism, and their joint contribution to reduce natural killer cell cytotoxicity. Natural killer cell activity was significantly lower in both depressed (n = 18) and alcoholic (n = 19) patients compared with control subjects (n = 50). In addition, patients with a dual diagnosis of either alcohol abuse and secondary depression (n = 9) or depression with a history of alcohol abuse (n = 26) demonstrated a further decrease in natural killer cell activity compared with that found in patients with either depression or alcoholism alone. While both depression and alcoholism are separately associated with a reduction of natural killer cell activity, subgroups of patients in whom the diagnoses of alcoholism and depression coexist show a further decrement in natural killer cell function.
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PMID:Major depressive disorder, alcoholism, and reduced natural killer cell cytotoxicity. Role of severity of depressive symptoms and alcohol consumption. 237 42

Thirty seven consecutive applicants to methadone maintenance were assessed for depression and for level of opiate dependence using a 0.8-mg naloxone challenge. Nineteen of the applicants met DSM-III-R criteria for current major depression. At 3-month follow-up, high naloxone challenge test (NCT) scores at intake (high levels of opiate addiction) were found to predict poor program retention and elevated symptoms of depression at follow-up. Reports of heavy current drug use at intake were also associated with poor program retention and with high frequencies of positive urine screens for illicit substances during treatment. Level of addiction and reported amount of drug use at intake independently predicted program retention with a multiple correlation of 0.46 (P less than .01). Although NCT predicted depression at follow-up, depression at intake did not significantly predict treatment outcome, and NCT score predicted outcome independently of psychopathology.
Am J Drug Alcohol Abuse 1989
PMID:Naloxone challenge as a biological predictor of treatment outcome in opiate addicts. 259 40

In a cross-sectional study, the psychological profile of light social drinkers was compared with that of heavy social drinkers and alcohol-dependent patients who showed no evidence of clinical depression. The selection of psychological tests was based on the hypothesis that alcohol abuse and depression may sometimes be different expressions of the same disorder, and that the relationship between the two disorders may in part be explicable in terms of shared psychological vulnerability factors. The tests chosen were those thought most likely to predict vulnerability to depression. Dependent patients demonstrated significantly greater distortion of cognitive style than heavy social drinkers, who in turn rated significantly higher than light drinkers. Heavy social drinkers occupied a middle ground with regard to psychological profile between light drinkers and 'alcoholics', sharing some attributes with each. Possible implication for interventions by general practitioners are discussed.
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PMID:Psychological profile of social drinkers. 259 9

Two hundred and four subjects, 22-35 years old, were selected from a suburban part of Khartoum. They were assessed using the Self-Rating Questionnaire, the Eysenck Personality Inventory, and a Sudanese rating scale of anxiety and depression. Socio-economic information was collected. A psychiatric interview and a medical examination were carried out. It was found that 40.3% had at least one psychiatric symptom, and 16.6% received clinical diagnoses according to DSM-III. The most common diagnoses were depressive illness (neurotic and endogenous) (8.4%) and generalised anxiety (3.4%). Alcohol abuse was very rare (0.4%). There was no sex difference.
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PMID:Epidemiology of mental disorders in young adults of a newly urbanized area in Khartoum, Sudan. 260 31

While suicide is the most dramatic cause of premature death in depressed older persons, it is a rare event in old age. Most of the excess mortality associated with late-life depression is due to "natural causes," especially cardiovascular illness. In the past much of the premature death related to psychiatric disorders was the result of epidemics in large, overcrowded institutions, and even today institutional factors may account for some excess mortality. A recent prospective study comparing depressed patients with nondepressed controls found that neither the initial level of physical health nor social factors explained the excess mortality, but it suggested that some of the excess is due to physical causes not readily apparent or disabling. The effects of grief, tricyclic antidepressants, chronic dysphoria, smoking and alcohol abuse, and organic brain disease are considered. Evidence suggests a complex interaction between depression and physical illness (particularly cardiovascular disease) that develops throughout life. Pursuant to these findings, some questions for future research are offered.
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PMID:Nonsuicidal mortality in late-life depression. 260 89

The influence of white rats of alcohol abuse formation of immunization by covalent conjugates of serum albumin with psychostimulant sydnophen was investigated. Immunization by conjugates where the molar sydnophen: protein ratio was 18:1-33: 1 results in significant depression of 15% ethanol consumption (in the condition of free choice between water and ethanol solution).
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PMID:[The immunization of white rats with a covalent conjugate of sidnofen and serum albumin suppresses chronic ethanol consumption]. 263 42

Differentiating between anorexia (loss of appetite) and weight loss (documented loss of pounds) can be difficult, but the same causes and treatments apply to both. Gastrointestinal and metabolic disorders, cardiopulmonary disease, the presence of a neoplasm or infection, and use of certain drugs are possible medical causes. Inadequate nutritional intake can result from the inability to obtain and prepare foods, dietary restrictions, intolerance to certain foods, and poor oral and dental health. Social factors that can greatly reduce an elderly person's interest in food include loneliness, depression, isolation, and self-consciousness because of hearing and visual impairments. Some problems, such as alcohol abuse or inappropriate use of certain medications, may be revealed only with difficulty, and some of the problems mentioned may overlap. Although the physician may find assessment of anorexia or weight loss in the elderly a challenge, it usually responds well to corrective measures.
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PMID:Anorexia and weight loss in the elderly. Causes range from loose dentures to debilitating illness. 264 36

Buspirone is a unique anxiolytic drug with established efficacy in the treatment of anxiety. In animals, buspirone has been shown to alter drinking preference from alcohol to water. The following study was conducted to evaluate the behavioral effects of buspirone in patients meeting the Diagnostic and Statistical Manual of Mental Disorders (3rd ed.; DSM-III) criteria of alcohol abuse. These patients were motivated to reduce or stop drinking, though none were abstinent at baseline. Buspirone was compared with placebo in a double-blind, 8-week trial in 50 outpatients with mild to moderate alcohol abuse. Patients were assessed at baseline and at end point using the following psychometric and alcohol behavior measures: Drinking Behavior Interview (DBI), Alcohol Craving Scale, the Hamilton Anxiety (HAM-A) Rating Scale, the Hamilton Depression (HAM-D) Rating Scale, and the Physician Questionnaire. Dosage was initiated at 5 mg buspirone 3 times a day (15 mg/day), with a flexible regimen to a maximum of 30 mg/day. The mean daily dose was 20.5 mg buspirone, which is comparable to the anxiolytic dose. Efficacy measures were available for 45 patients (24 buspirone, 21 placebo). The treatment discontinuation rate was markedly lower (p = 0.002) on buspirone; 12 placebo patients and 2 buspirone patients discontinued due to lack of effect (p = 0.001). No patients discontinued due to adverse effect. Buspirone reduced alcohol craving by 40% (p = 0.001), in association with reduced HAM-A and HAM-D scores (p = 0.006) and improved the physician's assessment of global psychopathology. Buspirone treatment was also associated with a 57% decrease in DBI scores; statistical comparison of the DBI data with placebo was precluded by the high discontinuation rate in the placebo group. While these results should be interpreted with caution due to the limited sample size and high placebo discontinuation rate, the findings suggest that further evaluation of buspirone in the management of alcoholism, especially abstinent alcoholics, is warranted.
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PMID:Buspirone in the treatment of alcoholic patients. 265 38


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