Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Electrocardiographic ST-segment depression in the anterior precordial leads is a frequent observation during the initial hospital phase of acute transmural inferior myocardial infarction (MI), but is of uncertain significance. No available clinical studies have examined the prevalence of inferoseptal necrosis complicating inferior MI. Therefore, the clinical course, electrocardiographic features, radionuclide angiograms and cardiac enzyme changes in 57 patients with transmural inferior MI who did not have prior anterior or concomitant "true posterior" MI, associated anterior or posterolateral asynergy by radionuclide ventriculography, or left or right bundle branch block were reviewed retrospectively. Patients were categorized according to the presence (group A) or absence (group B) of precordial ST-segment depression and according to the presence (group I) or absence (group II) of radionuclide septal wall motion abnormalities. There were no significant differences in global left ventricular ejection fraction (group A, 49 +/- 8, group B, 52 +/- 41; group I, 51 +/- 7, group II, 51 +/- 6), right ventricular ejection fraction (group A, 45 +/- 9, group B, 42 +/- 7; group I, 43 +/- 8, group II, 41 +/- 8), or clinical outcome in the hospital. However, chi-square analysis revealed a significant (p less than 0.05) association between the presence or absence of septal asynergy and the presence or absence of precordial ST depression. In addition, average peak creatine kinase elevation (group I, 761 +/- 164 IU; group II, 698 +/- 178 IU) attained marginal significance by paired t test (p = 0.06). Precordial ST-segment depression during transmural inferior MI is frequently associated with septal asynergy by gated radionuclide angiography (15 of 26 patients, 58%).(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Inferoseptal myocardial infarction: another cause of precordial ST-segment depression in transmural inferior wall myocardial infarction? 650 93

Electrocardiographic abnormalities were found in 53 out of 73 patients (72,6%) affected with progressive systemic sclerosis or scleroderma. Along with some modifications of little value, like heart rate increase or decrease, sporadic premature beats, slight ST depression or T-wave flattening, other more important abnormalities were recorded. One patient had atrial fibrillation and one supraventricular tachycardia. In 21 cases (28.8%) conduction disorders were found, including A-V block, right bundle branch block, left anterior hemiblock and bifascicular block. Low QRS voltages were present in 15 cases (20,6%), confined in all but one to the peripheral leads. In 13 patients (17,8%) Q or QS aspects suggesting myocardial necrosis were observed, but a clinical history or clinical picture of myocardial infarction syndrome was lacking in all cases but one. Electrocardiographic patterns of myocardial necrosis in scleroderma may indicate not only myocardial infarction, which seems to be a rather rare occurrence in such disease, but also intraventricular conduction system defects or progressive replacement of myocardium by fibrous tissue.
 ...
PMID:Electrocardiogram in progressive systemic sclerosis. Analysis of 73 cases. 660 93

The prevalence of right bundle branch block (RBBB) according to clinical findings was investigated in 4210 randomly selected subjects of both sexes, aged 35 to 54, in 1969 and after a period of three years (1972). Rheumatic heart disease and decreased forced vital capacity were more often found in persons with RBBB than in persons without RBBB. The prevalence of RBBB was 0.24% in 1969 and 0.35% in 1972. Incomplete RBBB (iRBBB) was found in 2.95% in 1969 and in 1.64% in 1972. The R1 smaller than the R wave in V1 or V2 was seen in 3.37% in 1969 and in 2.72% in 1972. RBBB remained constant over a period of three years, iRBBB was constant in 40.8% and R1 smaller than the R wave in V1/V2 was constant in 34.8%. Hypertension and depression of the S-T segment and inverted T wave before and after exercise were not more frequent in subjects with RBBB than in those without RBBB.
 ...
PMID:Right bundle branch block in a prospective population study. 661 10

In a population reportedly excessively prone to ischaemic heart disease (IHD) i.e. South African (SA) whites, a 3-community study of 7188 subjects aged 15-64 showed a high prevalence of chest pain by questionnaire (9.5% of males, 7.7% of females) or by ECG findings suggestive of IHD (12.8% males, 6.7% females). In the oldest decile (55-64 years) the prevalence of chest pain and/or ECG findings was 33.4% of males and 26.1% of females. For all ages, 18.4% of males and 13.1% of females were apparently affected. Though females were as likely as males to have a history of chest pain they had fewer ECG findings suggestive of IHD and the history was less likely to have been confirmed by a doctor. The significance of individual findings, assessed by the strength of their associations with symptomatic history and age, appeared to differ between the sexes; though very common, medium S-T depression was not classed as suggestive of IHD in females, while left ventricular hypertrophy was unimpressive in males. Large and medium Q waves, large S-T depression, large and medium T wave inversion were positive in both sexes, but left and right bundle branch block only in males. There was little overlap between a history of chest pain and suggestive ECG findings; however, a previous diagnosis of IHD by the family doctor increased the overlap by up to 6 times.
 ...
PMID:The prevalence of ischaemic heart disease in three rural South African communities. 669 35

The electrocardiograms of 559 persons, 83% of the total population 85 years of age or over in the city of Tampere, were evaluated according to the classification of the modified Minnesota code. Electrocardiograms showed no codable item in only 3.6% of the subjects. The prevalence of the most frequent electrocardiographic findings was: T wave inversion 53.3%, counter-clockwise rotation 42.9%, ST junction depression 42.8%, premature beats 33.8%, Q-QS pattern 21.3% and atrial fibrillation 17.4%. The prevalence of left axis deviation, left anterior hemiblock and right bundle branch block was statistically significantly higher in men than in women. Electrocardiographic abnormalities suggestive of ischaemic heart disease were present in 45.3% with no statistically significant relation to sex or age. The results are discussed and compared with those of electrocardiographic studies concerning age groups over 80 and 90 years.
 ...
PMID:Prevalence of ECG findings in very old people. 672 87

The nitroglycerin (NTG) exercise test can help in detecting ischemia in the presence of right bundle branch block (RBBB), left bundle branch block (LBBB), or digitalis-induced exercise ST changes and in excluding ischemia when a falsely positive test is suspected. This treadmill test has 3-min stages at 10% grade starting at 1.5 mph and progressing in 0.5 mph increments until ST depression is observed. NTG is then given as exercise continues at the ischemia-provoking work load for up to 10 min. Among 3 patients with RBBB, 5 with LBBB, 1 on digitalis and 2 with presumed falsely positive tests, those whose ST depression lessened after NTG had ischemic thallium exercise scans; those with no change in ST depression after NTG had normal thallium images. Additional studies are needed to verify the consistency of these findings among a larger group of patients.
 ...
PMID:The nitroglycerin exercise test. 679 35

Electrophysiologic evaluation before and after the serial administration of verapamil, lidocaine, propranolol, and procainamide was undertaken in 4 young, asymptomatic patients with recurrent, sustained ventricular tachycardia (VT). No patient had obvious organic heart disease. The electrocardiogram during sinus rhythm showed S-T depression and T-wave inversion over the inferior and lateral precordial leads in 3 patients. QRS morphologic characteristics during episodes of VT showed a pattern of right bundle branch block and left axis deviation. In all 4 patients, VT could be both induced and terminated with electrical stimulation. Verapamil terminated VT and prevented the induction of sustained VT in 3 patients, and markedly slowed the rate of VT in 1 patient. Procainamide effectively prevented the induction of sustained VT in 2 patients, and although ineffective in preventing induction in 2 patients, it slowed the rate of tachycardia in both. Lidocaine and propranolol did not prevent the induction of VT in any patient. These findings suggest that slow-response tissues may be involved in the genesis of VT in these patients, and that VT in these patients may represent a unique clinical entity with distinct electrocardiographic, electrophysiologic, and electropharmacologic properties.
 ...
PMID:Idiopathic paroxysmal ventricular tachycardia with a QRS pattern of right bundle branch block and left axis deviation: a unique clinical entity with specific properties. 685 37

Thirty patients with variant angina pectoris (VAP) were analyzed for electrocardiographic features during episodes of VAP. Twenty-nine of these patients had cardiac catheterization, and an autopsy study was performed in one. The patients showed predominantly concave upright T-waves during pain. An increase of R wave amplitude (expressed as delta R) of more than 10% was seen in 17/30 patients (57%). The primary ST-T changes produced by the VAP episodes were conspicuous in two patients with pre-existent complete left and right bundle branch block. Serious dysrhythmias, including ventricular fibrillation (VF), ventricular tachycardia (VT), ventricular premature beats (VPBs) (more than five/min, multifocal and R on T phenomenon), and 2 degrees atrioventricular block were found in thirteen patients (43%). The development of dysrhythmias was related to the duration of VAP episodes. The average time to onset of dysrhythmias was 3.54 min. The dysrhythmias were not contingent upon pre-existing coronary artery anatomy (defined by Friesinger's coronary score), left ventricular ejection fraction or left ventricular segmental abnormalities. The location of the ST-segment elevation and the presence of dysrhythmias during the episodes of VAP (A-V blocks, ventricular tachycardia and fibrillation) were not predictive factors of the coronary anatomy. Eight patients (27%) developed myocardial infarction (MI). Five of them had nontransmural MIs and three developed transmural MIs. The development of MI was not related to the severity of the VAP attacks (appreciated by the magnitude of ST-segment elevation and R wave changes) but showed a relation to the development of an unstable pattern which preceded the infarction. Sixteen patients underwent exercise testing. In eight of them, the coronary arteriograms were normal (Group I); in the remaining eight, significant proximal coronary artery obstructive disease was found (Group II). Group I patients displayed a normal ST-segment response and functional aerobic capacity (FAI = 4.4 +/- 14) as well as normal heart rate (HR) and double product (SBP X HR) responses (HR = 154 +/- 21; SBP X 21; SBP X HR = 290 +/- 71). During exercise, a normal delta R was observed. With one exception, Group II patients showed an abnormal ST-segment response with an overall low exercise capacity (FAI = 57 +/- 17) and decreased hemodynamic response (HR = 27; SBP X HR = 130 +/- 40). FAI, HR, SBP X HR Group I vs. Group II = P less than .005/less than .02/less than .005. The abnormal ST-segment response included elevation in four patients and depression in three. During exercise, Group I with ST-elevation displayed a normal (negative) delta R response; while Group II with ST-depression displayed an abnormal delta R response (positive or no change). There was no difference in the coronary score between Group II patients with ST-segment elevation or depression.
 ...
PMID:Prinzmetal's variant angina: electrocardiographic and angiographic correlations. 714 73

The results of exercise stress test in 86 patients with intraventricular conduction troubles (BBBand or Emiblock) are discussed in order to asses the meaning of exercise induced ECG alterations and possibly of an etiopathogenetic interpretation. The AA. examined the following parameters during stress test and recovery: max heart rate, percent of teoric max heart rate, max BP, max heart rate x BP product, AQRS at rest and during recovery immediately after exercise test, QRS duration, ST depression, T amplitude. The majority (91,67%) of isolated RBBB patients had negative test; 30,43% of RBBB + LAEmiblock patients had ECG signs and clinical symptoms of myocardial ischemia. In LBBB patients the test was considered positive only if present ST depression and precordial pain. The AQRS tends during exercise to the right; in the 60% of RBBB + LAEmiblock patients it can be seen a tendency to left axis deviation; the amplitude of T-wave is increasing in more than 50% in LBBB. The conclusions are that in patients with intraventricular conduction troubles the interpretation of results is always difficult; the presence of clinical symptoms like precordial pain may give an aide when associated to the ECG variations.
 ...
PMID:[The exercise stress test in patients with intraventricular conduction troubles (author's transl)]. 746 61

The value of exercise testing in patients with right bundle branch block (RBBB) is uncertain. A retrospective review of 3609 patients who underwent exercise testing identified 163 (4.5%) with preexisting RBBB. After excluding those with coronary artery bypass graft(s), 133 patients remained and 48 (36%) had a prior myocardial infarction. Angiograms were available for 30 (23%) patients. After a mean follow-up of 33 +/- 23 months, seven patients had a fatal or nonfatal myocardial infarction. Twenty five (19%) patients had > or = 1 mm of non-upsloping ST depression in leads V5 or V6. With angiographic disease or previous myocardial infarction used as endpoints of coronary artery disease, the exercise test had a sensitivity of 27% (15/56), a specificity of 87% (67/77), and a predictive accuracy of 62% (82/133), (chi 2 = 4.04, p = 0.04). There were 24 deaths, a 10% annual mortality rate. Univariate analysis of clinical, exercise, and angiographic data revealed that nonsurvivors had a lower peak systolic blood pressure, a lower exercise capacity in METS, and a higher prevalence of coronary artery disease (p = 0.0001, p = 0.02, p = 0.03, respectively). Left ventricular ejection fraction and the amount of additional ST depression during exercise did not differ significantly (p = NS). Receiver operating characteristic curve analysis revealed that systolic blood pressure (area = 0.741, z = 5.22, p < 0.001) and exercise capacity (area = 0.66, z = 3.12, p = 0.009) were predictive of mortality, whereas additional ST depression during exercise (area = 0.588, z = 0.70, p = 0.24) was not.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Diagnostic and prognostic accuracy of the exercise electrocardiogram in patients with preexisting right bundle branch block. 819 78


<< Previous 1 2 3 4 5 6 Next >>