Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We relate two cases of amineptine (Survector) overconsumption by patients cured for atypical depression with asthenia and activities deficit as the prevalent symptoms. Prescription of two tablets a day (0,200 g) was respected in one case during six months, and in the other case during two years, with therapeutic benefit on apragmatism. To no obvious reason, within few months both patients had gradually raised the doses to twenty tablets (2 g) and thirty tablets (3 g) respectively: we observed subexcitation, insomnia, sensorial hyperaesthesia, irritability, tachyphemia with dysarthria, anorexia with weight lost of more than 10 kg and amphetamine-like troubles without confusion or delusion, as a result of which both patients were treated for their addiction, in hospital. Treatment with clorazepate perfusions did not cause any physical dependence problems. However, psychological dependence was strong enough for one of the patients to go out, on the third day, against medical decision. As far as we know, in France, only one such case of addiction use at high doses and in single intakes is mentioned in the existing literature. However, our observations suggest that it might be necessary to re-assess the place of amineptine among new antidepressive molecules with psychostimulant abilities.
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PMID:[2 cases of amineptine dependence]. 614 28

Street opiate addiction produces a significant depression in the absolute number of total T lymphocytes in peripheral blood as measured by the ability of the lymphocytes to rosette sheep red blood cells (SRBC). Associated with the decrease in T cells, there is an increase in the absolute number of null lymphocytes but no significant changes in B lymphocytes or total white blood cell count. The T cell values for 2 different populations of addicts (n = 12 and 32) are 31.8% and 23.1%, whereas the null cell values are 51.1% and 57.6%, respectively. The values for comparable control populations (n = 18 and 10) are: T% = 70.7% and 67.4%, and null % = 9.2% and 14.5%. Self-reported use of marihuana does not significantly alter the distribution of cell populations. A 1- to 3-hr incubation of addicted-derived lymphocytes with 10(-6) to 10(-7) M Naloxone reverses both T cell depression and null cell increase by allowing the null cells to express SRBC receptors. Cyclic AMP and dibutyryl cyclic AMP can also convert the null cells to T cells. The conversion of null to T lymphocytes has additionally been measured by monitoring the increase in PHA-stimulated growth in 72-hr cultures as determined by tritiated thymidine incorporation into DNA. These results support the hypothesis that opiates can alter T lymphocyte number and function in vivo, and that this alteration may produce a significant degeneration in the immune competence of street opiate addicts.
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PMID:Alteration of T and null lymphocyte frequencies in the peripheral blood of human opiate addicts: in vivo evidence for opiate receptor sites on T lymphocytes. 625 68

One hundred and eighty patients (American Society of Anesthesiologists rating 1-2) received one of three oral analgesics--ciramadol (Wy. 15705) 20 mg, ciramadol 60 mg or codeine 60 mg--on a double-blind random basis for the relief of pain 24-48 hours after major general surgical, gynaecological or orthopaedic operations. All three analgesics proved equally effective and caused mild sedation only. No patient showed signs of clinical cardiorespiratory depression, and other side-effects were infrequent. Ciramadol may therefore prove a useful clinical alternative to conventional oral analgesics provided its lack of respiratory depressant properties and addiction potential in monkeys can be substantiated in humans.
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PMID:Ciramadol--a new synthetic analgesic. A double-blind comparison with oral codeine for postoperative pain relief. 635 86

Opiate addicts and polydrug, but nonopiate, substance abusers were assessed for depression on the Raskin rating scale for a clinical interview and several self-report measures of depression including the Hamilton, SCL-90, and the recently developed Depressive Experiences Questionnaire (DEQ), which differentially assesses depression focused around neediness from a depression focused around self-criticism (guilt and shame). Opiate addicts were consistently more depressed than polydrug drug abusers on all the measures. On the DEQ, opiate addicts were significantly (p less than .001) more depressed than normals and even somewhat more depressed than psychiatric patients. This depression, however, was focused primarily around issues of self-criticism, guilt, and shame rather than issues of dependency, abandonment, rejection, and neglect. Even further, depression focused around self-criticism, as measured on the DEQ, was significantly correlated (p less than .001) with the extent to which the polydrug, non-opiate-addicted substance abusers had begun to experiment with opiates. These data suggest that intense depression, particularly depression focused around issues of self-criticism, has an important role in opiate addiction.
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PMID:The psychodynamics of opiate addiction. 654 6

Children who were born in the early 1980s in the Stockholm suburb that was studied had a home environment that may be described as follows. The material standards in the area were good, the dwellings were spacious and modern, the outdoor environment was pleasant for children and the municipal service facilities were well developed. The transport services to the city are frequent, comfortable and convenient. In a typical case, the parents are about 30 years old, they are of old Swedish stock and are living together, married or unmarried. They received a good education and usually also occupational training. Generally, both parents have a job outside the home. In quite a few such cases the mother has shift- or nightwork. Although both parents have jobs, the family surprisingly often has financial problems. Thus more than one family in five needed financial assistance from the authorities. The financial difficulties may be due to illness and addiction in the parents. About one in ten of the mothers has been hospitalised for a chronic somatic disease and about one in ten of the fathers is in the records for alcoholism. Criminality is also common, every sixth or seventh father having a police record. About every fourth child born in this suburb will grow up in a home where either the father or the mother is known for an addiction and/or criminality, and/or has been treated for mental illness. To conjure up and describe the atmosphere in a home in this suburb is not easy but in the present study information was obtained supporting the suspicion that many homes are characterised by insecurity, isolation and hopelessness and a serious unsatisfied need for help. Many of the mothers have grown up in rather special social conditions--for instance, in "broken homes", or with an alcoholic father or a mentally ill mother. As a result, nearly every tenth mother had been placed outside the home at an early age (in a foster-home or suchlike). In later years also, many of the mothers have had the burden of sick, malformed or mentally retarded children in their home, or have experienced the serious illness or death of some person close to them. Particularly in the period before their child's birth many women have had reason to feel anxious. About one woman in three has already had a miscarriage and/or abortion, and during pregnancy she may have suffered from serious nausea or depression. Quite a few also needed to take medicines during that time. In many families, it is reported, the man and woman have had trouble in living together, with resultant divorce situations, quarrels and assaults.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Home environment of children in a new Stockholm suburb. A prospective longitudinal study. 658 82

Data collected by the Quebec Board of Physicians show that during the 5 years from 1974 to 1978 the prevalence of addiction to opiates among Quebec physicians was 2.8/1000. The physician addicts had greater mobility and a higher attrition rate than their peers. The typical addict was male, a general practitioner and married. He often suffered from pain, fatigue, overwork, and financial and marital difficulties. His addiction had begun at approximately 35 years of age and had become evident about 3 1/2 years later. Meperidine was the preferred opiate. Some of the physicians lost their licences to practise for variable periods of time; for these the prognosis was gloomy. Depression was the main psychiatric disorder diagnosed.
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PMID:Drug addiction among Quebec physicians. 707 90

Personality measures are known to differentiate alcoholics from nonalcoholics, and the pattern of addiction displayed by alcoholics also appears to be related to personality factors. In the present study anxiety, depression, and self-esteem were measured in 22 gamma alcoholics, 16 delta alcoholics, and 20 social drinkers. Alcoholics were found to be more extreme than social drinkers on all three questionnaire measures. Gamma alcoholics tended to be more deviant than delta alcoholics, but their lower self-esteem was the only measure that reached statistical significance. Generally, the results are consistent with previous findings that indicate a relationship between abnormality of drinking pattern and degree of personality deviance.
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PMID:Personality measure in gamma and delta alcoholics: a brief note. 739 Dec 52

Fifty physicians were evaluated and treated in a psychiatrically oriented, short-term addiction program. Psychopathology ranged from overt schizophrenia to no demonstrable psychiatric syndrome other than the addiction. Physicians experiencing addiction problems before age 40 years were more likely to exhibit serious psychopathology in the borderline range, while physicians older than 40 years were more likely to exhibit organic brain impairment and depression. Treatment outcome had some relation to psychiatric diagnosis but no relation to the addictive agent.
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PMID:Addicted physicians. A closer look. 745 50

Previous research has shown that a majority of drug-dependent subjects respond to drug cues in the laboratory with increased craving; however, approximately one-third are not cue responsive. The current study examined differences between responders and nonresponders to cocaine cues in a sample of 69 cocaine-dependent methadone patients. Subjects completed questionnaires assessing selected dimensions of addiction and participated in a cue-reactivity protocol that assessed both cocaine craving and cocaine aversion in response to cues. Four groups of subjects were identified on the basis of their cue responses: (a) increased craving plus decreased aversion; (b) increasing craving only; (c) decreased aversion only; (d) no increase in craving and no decrease in aversion ("nonresponders"). No group differences were found in severity of cocaine dependence, depression, or on any demographic variable, with the exception of parental status. Group differences were found on measures of cocaine expectancies and self-efficacy. There is a discussion of the bearing of these findings upon explanations offered in the literature for nonreactivity to drug cues.
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PMID:Differences between responders and nonresponders to cocaine cues in the laboratory. 748 15

Thought-intrusions, automatic inferences, and other unintended thought are beginning to play an important role in the study of psychiatric disease as well as normal thought processes. We examine one method for the study of task-unrelated imagery and thought (TUIT). TUIT likelihood was shown to be reliably measured over a wide range of vigilance tasks, to have high short-term and long-term test-retest reliability, and to be sensitive to information processing demands. Likelihood of TUITs was shown to be different as a function of aging, hyperactivity, time of the day, and level of depression. Thus, we now can reliably measure the influence of endogenous and exogenous influences on TUITs. In addition, TUIT measurement was proposed as a minimally interfering and natural second task for determining resource utilization in a primary task. Finally, this method was offered as a reliable approach to quantification of such mental states as obsessions and drug craving and addiction.
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PMID:A laboratory method for investigating influences on switching attention to task-unrelated imagery and thought. 749 92


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