Gene/Protein
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Pivot Concepts:
Gene/Protein
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Target Concepts:
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Query: UMLS:C0011570 (
depression
)
172,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Stress is an inevitable part of life in today's society. Some stress may be beneficial and can lead to improved productivity. Unless suitably managed, however, stress may contribute to physiological and psychological dysfunctions such as
depression
, fatigue, obesity, coronary heart disease, suicide, or
violence
. The impact of stress on the Nation's physical and mental health may be considerable. Tens of thousands of premature deaths annually are consequences of suicide and homicide. It is estimated that 2,000 deaths to children and up to four million injuries inflicted by abusing parents occur each year partially as a result of stress. Recent years have focused a considerable amount of public and professional interest upon the relationship between stress and physical and mental health. Scientific inquiry has demonstrated various associations between stress and health and disease and has provided evidence that stressful factors can be assessed. Much remains, however, to be elucidated about vulnerability to stress and its control. Some groups such as teenagers, the elderly, and the economically disadvantaged appear to be more vulnerable to stress, and the public in general has limited information about what can be done to reduce stress. There is a clear need to investigate the psychological, environmental, and biological interactions which link stress to health disorders.
...
PMID:Health promotion: Control of stress and violent behavior. 641 16
Cocaine is a powerful euphoriant and it relieves, though only transiently,
depression
, dread and dysphoria. New patterns of cocaine abuse, such as the inhalation of vaporized cocaine base, the intravenous injection of cocaine hydrochloride and the smoking of coca paste, produce a brief elation that quickly gives way either to a return to the baseline mood or to displeasure, resulting in a strong desire to return to the momentary ecstatic experience, a cycle that leads to compulsive use. The enormous profits made from illicit traffic in cocaine lead to corruption,
violence
and political destabilization. The individual costs of cocaine abuse include loss of personal fortunes, jobs and families. The safety of cocaine use is a myth. There are a number of ways in which cocaine can be lethal. The high doses of cocaine abused today induce physical dependence, but this is less a contributory factor than the intense psychological craving to perpetuate cocaine use. There is no specific way to treat dysfunctional cocaine use; instead the treatment plan must deal with the individual's specific situation. Except for a reduction of cocaine supply at the source, preventive measures are only feasible in the context of abstinence from all abusable drugs.
...
PMID:Recent developments in the abuse of cocaine. 644 Jun 13
Several studies are summarized in which the relationship of high prolactin levels and self-rated anger-hostility was examined. The Symptom Questionnaire, a state measure which contains an anger-hostility scale, was included in all studies. Women with hyperprolactinemic amenorrhea were found to have higher hostility scores than amenorrheic women with normal prolactin levels. In another study, hyperprolactinemic women were found to have higher hostility scores than female family practice patients, random employees and there was a nonsignificant trend for higher hostility scores than in female nonpsychotic psychiatric outpatients. In both studies,
depression
and anxiety were also significantly higher. When bromocriptine, a prolactin lowering drug, was administered to hyperprolactinemic women in a double blind crossover study, there was a significant and progressive decrease of hostility,
depression
and anxiety while on bromocriptine, parallel with the decrease in prolactin and no change on placebo. Post-partum women who had high prolactin levels were significantly more hostile than a control group of employees and as hostile as hyperprolactinemic women. Hyperprolactinemic males were no more hostile than controls. The relationship of prolactin to post-partum aggression in mammals is briefly reviewed. The findings are inconclusive; in the three species studied, postpartum aggression is perhaps enhanced, but does not depend on high prolactin levels. There are no studies on the relationship of prolactin levels and
violence
in women. Hostility associated with high prolactin levels in postpartum women is perhaps a phylogenetic remnant which may have had the evolutionary advantage of protecting the young.
...
PMID:Prolactin, aggression and hostility: a discussion of recent studies. 648 49
To test the hypothesis that suicidal and self-destructive behaviour correlate with subjective and objective measures of hostility and
violence
, these behaviours in hospitalized schizophrenics were correlated to self-report (Buss-Durkee) and observer-rated (Lion Scale) measures. Self-destructive acts were significantly correlated with six of the seven of the Buss-Durkee self-report hostility subscales. The observed measures of hostility and
violence
correlated with seclusion and with restraint as a self-protective measure. Neither the Lion nor the Buss-Durkee measures correlated with
depression
measures. Thus, our data indicate that self-destructive acts in hospitalized schizophrenics may be better predicted by feelings of anger and hostility than by
depression
, a finding with relevance for clinicians who treat schizophrenic patients.
...
PMID:Relationships between measures of direct and indirect hostility and self-destructive behaviour by hospitalized schizophrenics. 661 17
Suicidal and other self-destructive behavior was correlated with self-report (Buss-Durkee) and observer rated (Lion Scale) measures of hostility and
violence
in 45 male inpatients with major depressive episodes by DSM III criteria (296.2, 296.3, 296.5). Self-destructive acts were significantly correlated with a Buss-Durkee Indirect Hostility factor. Measures of directly expressed hostility and
violence
correlated with seclusion and restraint for self-protection. None of the Lion or Buss-Durkee measures correlated with
depression
measures, nor did self-destructive acts correlate with degree of
depression
in these severe patients. Thus our data indicate that, in patients with moderate to severe
depression
, self-destructive acts in hospital may be better correlated with feelings of anger and hostility than with
depression
itself.
...
PMID:Direct and indirect hostility and self-destructive behavior by hospitalized depressives. 665 Feb 12
This study suggests a conceptual framework for examining the impact of stress (i.e., level of
violence
), personal resources, social support, institutional responsiveness, and coping upon the psychological health (i.e.,
depression
, mastery, and self-esteem) of battered women. Respondents were 60 women who had sought assistance from a shelter for battered women. Results indicated that increased levels of
violence
, minimal personal resources, lack of institutional and informal social support, and greater avoidant coping styles were related to lowered self-esteem and more severe depressive symptoms. Exploratory analyses suggested that stress (i.e., level of
violence
) and personal resources may have indirect effects upon functioning through their impact on coping responses and the availability of social support. In particular, women who had fewer social contacts unaccompanied by their partner were less likely to receive supportive responses from friends. Implications for research and practice are discussed.
...
PMID:Coping with domestic violence: social support and psychological health among battered women. 666 51
A review of the literature has been made on the diagnostic, management and administrative procedures adopted by military psychiatrists during the Vietnam conflict. Initial reports of low rates of psychiatric attrition probably concealed much combat-related psychopathology by labelling these problems as administrative disciplinary infractions. In the later stages of the war, explosive outbreaks of substance, particularly heroin, abuse were noted as well as reports of serious
violence
directed towards superior officers and Vietnamese civilians. Successful coping styles adopted by the troops against combat stress, culture shock and anomie have also been described as have their stratagems for managing a return to a politically divided community. Studies on returned veterans point to ongoing psychopathology in the areas of post traumatic stress disorder and
depression
in proportion to the severity of the combat to which they were exposed. Increased rates of
violence
and alcoholism have yet to be demonstrated. The therapy of veterans with adjustment problems and post-combat psychiatric disorders has also been reviewed.
...
PMID:The Vietnam veteran ten years on. 696 Aug 83
Although an association of psychiatric symptoms with vitamin B12 deficiency is well accepted, the incidence and nature of these symptoms is not established. To help illuminate the natural history of this illness we review the literature regarding psychopathology associated with B12 deficiency and examine 15 cases, including one of our own, that meet specified criteria for B12-responsive psychosis. In the accepted cases the most common psychiatric symptoms were organic brain syndrome, paranoia,
violence
, and
depression
. Several of the patients were not anemic and had no neurologic deficit. Examination of blood smears or obtaining of serum B12 levels should be considered for patients with the symptoms described.
...
PMID:B12 deficiency and psychiatric disorders: case report and literature review. 701 36
Young chronic patients are faced with the same concerns and life-cycle stresses as others in their age group. They strive for independence, satisfying relationships, a sense of identity, and a realistic vocational choice. Lacking the ability to withstand stress and intimacy, they struggle and often repeatedly fail. The result is anxiety,
depression
, psychotic episodes, and hospitalizations; gradually many begin to give up the struggle. Such concerns may become intensified during the reassessment of life that takes place at about age 30. Denial of illness, the rebelliousness of youth, and issues of control and
violence
compound the problems. Since deinstitutionalization, patients can no longer take asylum from stresses in a lifetime of hospitalization. Many patients drift from one city to another, or from one living situation to another. Some ways of approaching these problems, such as working with younger patients while they may still be motivated to make changes, helping them develop appropriate rationalizations, and supporting realistic goals, are discussed.
...
PMID:Young adult chronic patients: the new drifters. 709 68
This article describes a large group in a district general hospital serving a defined catchment area. Fifteen consecutive meetings were studied and three types of meeting were observed; manic meetings, depressed meetings and, thirdly more balanced meetings not dominated by any powerful affect. The main topics discussed in the meetings included
depression
, illness, anxieties about treatment or recurrence, doctors, bereavement, loneliness, religion, and death, the more medical subjects possibly reflecting the medical orientation of the treatment programme. The principal themes in this meeting differ from those described in therapeutic communities, when themes of
violence
, rejection, sexuality and dependence conflicts figure more prominently. In the setting of the district general hospital, the character of the meeting appeared to be largely determined by the composition of the ward at the time, and patients with affective disorders. by virtue of their powerful moods, often assumed a dominant role.
...
PMID:A large group in a district general hospital. 731 9
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