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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Phencyclidine use appears to be in a growth phase nationally. Factors contributing to the increasing popularity include the user's ability to control the dosage, an understanding of the immediate effects, and its availability. Those most at risk appear to be young Caucasian males. Phencyclidine-related problems are often like tips of icebergs, the underlying causes of which are hidden from public view. The problems often surface in the form of speech difficulties, memory loss, thinking disorders, personality changes, paranoia, severe depression, violence, accidents, suicides and homicides. Of particular concern to law enforcement personnel is the upsurge in phencyclidine-related violent crimes and carrying of weapons by users to protect themselves from their imagined persecutors. The evidence currently available supports the assumption that if there is a solution to the problem of phencyclidine abuse, that solution is prevention. Therefore, medical personnel and others within the helping professions must be alerted to the fact that phencyclidine is not just another drug problem. The findings from users we have already studied strongly suggest that phencyclidine is not an "upper" or a "downer," but perhaps an "insideouter", with longer term implications.
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PMID:Phencyclidine use among youth: history, epidemiology, and acute and chronic intoxication. 10 77

Violence is a symptom of an underlying mental state such as a psychosis, a characterological problem, or brain dysfunction. Thus drugs used to treat aggression in man exert effects by their specific pharmacological actions (e.g., antipsychotic, anticonvulsant). Most literature to date has dealt with animals and human models of aggression and lacks conceptual clarity. Aggression differs from depression, a coherent clinical entity, in its etiological diversity and its paroxysmal or impulsive basis, and this may account for the relationship seen in literature linking violence to epilepsy; yet literature on anticonvulsants is equivocal with regard to beneficial effects on aggression. Lithium has been shown to have positive effects, although its mode of action is unclear. A variety of antipsychotic agents and minor tranquilizers have been mentioned. Central nervous system stimulants have been found useful to treat hyperkinetic syndromes in both children and adults where aggression is a symptom. Hormonal agents are discussed. Drug treatment of aggression should not obscure the need for verbal therapies, and social and environmental factors should always be regarded.
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PMID:Conceptual issues in the use of drugs for the treatment of aggression in man. 23 9

Information was obtained from 95 incarcerated female prisoners on their history of violence, on their feelings of depression, their suicide attempts, and on their history of loss of parents. The data revealed that the loss of father before the age of 10 years was more highly correlated with signs of depression in these women prisoners than was loss of mother. Women who reported at least one suicide attempt in the past were significantly more depressed on the self-report measure of depression than the other women, and were more likely to be judged as violent on the basis of several independent indices. The results support the hypothesis that violence toward others and suicidal behavior are part of the same phenomenon of impairment in control mechanisms.
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PMID:Parental loss, depression and violence. III. Epidemiological studies of female prisoners. 85 75

This study investigated the effects of childhood sexual abuse and parental alcoholism in a sample of university women. Current symptoms of anxiety and depression were measured together with retrospective reports of subjects' families of origin. Using a 2 x 2 factorial design, main effects on symptoms were obtained for sexual abuse and parental alcoholism, but their interaction was not significant. With respect to family environment, a history of sexual abuse was associated with perceptions that families of origin had less cohesion, more conflict, less emphasis on moral-religious matters, less emphasis on achievement, and less of an orientation towards intellectual, cultural, and recreational pursuits. Similarly, subjects who had alcoholic parents reported less family cohesion, more conflict, and less emphasis on moral-religious matters. Results of analyses of covariance suggested that family environment was a mediator of current symptoms of anxiety, but not symptoms of depression.
Violence Vict 1992
PMID:Joint consequences of parental alcoholism and childhood sexual abuse, and their partial mediation by family environment. 130 38

The efficacy, safety, and performance of triazolam was compared with those of other shorter-acting hypnotics acting on the gamma-aminobutyric acid (GABA) receptor--zopiclone, zolpidem, midazolam, brotizolam, temazepam, lormetazepam, and loprazolam. In all, 5506 patients participated in 38 clinical and epidemiologic studies, of whom 2462 were treated with triazolam in parallel-design and crossover studies. To provide clinically relevant comparisons, only studies using comparator agents in doses equipotent to the triazolam doses were included. Two general findings emerged. First, "serious" central nervous system side effects, such as excitement and violence, were not demonstrated for any of the hypnotic agents, including triazolam. Other central nervous system side effects, such as depression and irritability, were reported with equal frequencies for all the hypnotics reviewed. Rebound insomnia, reported intermittently with most of these agents, was short-lived and not clinically significant. So-called early morning insomnia was noted only once and does not appear to be a valid clinical entity. Daytime anxiety was not observed in large numbers of triazolam-treated subjects studied, which is contrary to claims that the drug is anxiogenic. Second, a remarkable similarity was found among all of these shorter-acting agents in terms of efficacy, side effects, and performance-related effects. This was particularly of note for zopiclone and zolpidem. Although claims have been made suggesting differences, evaluation of the studies herein showed that these nonbenzodiazepine hypnotics were indistinguishable from triazolam and other benzodiazepine hypnotics in their clinical and pharmacologic activity. Thus, different chemical structures did not a priori predict different clinical profiles when drugs share a similar mechanism of action.
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PMID:Comparative clinical profiles of triazolam versus other shorter-acting hypnotics. 133 76

This study describes the prevalence of violence and the putative risk factors for violence in 184 Alzheimer patients and their primary caregivers living in the community. Analysis of the severe violence subscale of the Conflict Tactics Scale indicated that 15.8% of patients had been violent in the year since diagnosis. A total of 5.4% of caregivers reported being violent toward the patient. The overall prevalence of violence was 17.4%. The variables most associated with violence were caregiver depression and living arrangement.
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PMID:Severe family violence and Alzheimer's disease: prevalence and risk factors. 142 52

African American women are often identified as a group at high risk for depression; they are also viewed as either delaying or not seeking treatment for the depression. The assessment, diagnoses, treatment, and prevention of depression in African American women require special sensitivity. To determine whether special sensitivity is shown to this population, this review examines the literature on African American women and depression, and critiques the major scales used in assessing depression. Violence is identified as an additional risk factor for depression in African American women. It is suggested that an interactive approach to risk factors for depression in African American women provides a better basis for psychiatric nursing practice with this population.
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PMID:African American women and depression: a review and critique of the literature. 147 52

This study is based on interviews with and psychiatric ratings of female family violence victims and male non-family violence victims. Despite differences in the type of violence and the relation to the assailant, the psychological consequences of the battering were very much the same in the two groups. The background and present social situation of the victims were very similar. The conclusion drawn with regard to the medical services, is that both groups of victims need the same attention and treatment when attending the emergency department. Apart from routine medical care, they might need treatment for alcohol problems, depression or other psychiatric conditions frequently occurring in victims of violence.
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PMID:Do not forget the battered male! A comparative study of family and non-family violence victims. 148 55

Battering during pregnancy affects the health of both pregnant women and their unborn children. The purpose of this retrospective study of 488 primarily Medicaid-eligible postpartum women was to identify the constellation of factors associated with violence. The prevalence of battering during pregnancy was 7%, similar to that found in other studies. Significant correlates of battering included anxiety, depression, housing problems, inadequate prenatal care, and drug and alcohol use. Woman battering by a partner during pregnancy was associated with a greater severity of this constellation of patterns than those experiencing abuse before pregnancy only, or those experiencing physical attack by someone other than their partner. These factors are important to recognize in nursing assessment of pregnant women.
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PMID:Correlates of battering during pregnancy. 150 14

This study investigated the prevalence of unwanted sexual activity among 949 college women who completed a history form for routine gynecological care at the health center of a private university. Included on the form were standard questions regarding gynecological and menstrual history, methods of contraception, sexual history, sexual dissatisfaction, and feelings of depression. In addition, the question "Have you ever experienced unwanted sexual activity?" was asked. Of the women sampled, 6.7% responded to this question affirmatively, far fewer than report such activity in anonymous surveys. These women were significantly more likely than their peers to be sexually active and to report having had abortions and pregnancies to term or having experienced sexual dissatisfaction and depression. Results highlight the tendency of victims of sexual violence to underreport their experiences and point to the importance of inquiry into unwanted sexual activity in campus primary care settings.
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PMID:Unwanted sexual activity: the prevalence in college women. 158 38


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