Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 24-year-old oil well tester was rendered semiconscious by hydrogen sulfide (H2S). He received oxygen and was hospitalized but released in 30 minutes. The next day, nausea, vomiting, diarrhea, and incontinence of urine and stool led to rehospitalization. These problems and leg shaking, dizziness, sweating, trouble sleeping, and nightmares prevented his return to work. A physical examination, chest x-ray, and pulmonary function tests were normal 39 months after the episode but vibration sense was diminished. Two choice visual reaction times were delayed. Balance was highly abnormal (5 to 6 cm/sec) with eyes closed. Blink reflex latency was slow (R-1 17.5 msec versus normal 14.3 msec). Numbers written on finger tips were not recognized. Verbal and visual recall were impaired but overlearned memory was intact. Cognitive functions measured by Culture Fair, block design, and digit symbol were impaired. Perceptual motor was slow. Scores for confusion, tension-anxiety, depression, and fatigue were elevated and vigor was reduced. Forty-nine months after exposure his reaction time, sway speed, and color vision had not improved. His recall and his cognitive, constructional, and psychomotor speeds had improved but remained abnormal. These deficits are most likely due to H2S. Similar testing of other survivors is recommended.
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PMID:Case report: profound neurobehavioral deficits in an oil field worker overcome by hydrogen sulfide. 823 84

Prejudices against the aged are called ageism. A case demonstrates its obscure effects. Ageism is seen as antipathy or hate, too. But a common societal reality of ageism is not being able to take different perspectives. Seeing the challenge of a concrete clinical situation means varying the ethical perspectives both care and fairness. According to that, "multidimensional" assessment characterizes geriatrics. Examples for not being able to take varying perspectives are given when adults are confronted with suicide, sexuality/tenderness, convictions, depression, religiosity, reduced memory capacity, quality of life, incontinence, dying etc. of the aged. The paper shows three ways of controlling cognitive and affective dimensions of prejudices in general.
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PMID:["Ageism": prejudice against age]. 827 11

A study of irritable bowel-type symptoms in 1264 health examinees using a self-administered questionnaire and psychological tests revealed they are common throughout adulthood. Of affected subjects 68% were female, and those with the more severe type (> or = 3 Manning criteria) were predominantly female (80%). Fewer Asians than other racial/ethnic groups had these symptoms. Nongastrointestinal symptoms, physician visits, incontinence, laxative use, a stress effect on bowel pattern and abdominal pain, abdominal surgery, hysterectomy, childhood abuse, use of mind-altering drugs, depression, and anxiety were correlated with irritable bowel-type symptoms. Regression analysis found some of the clinical correlates were independent markers for irritable bowel-type symptoms and that sexual abuse was related to nongastrointestinal symptoms and abdominal surgery independent of irritable bowel-type symptoms. More severe irritable bowel-type symptoms were especially associated with nongastrointestinal symptoms, stress effects, sexual abuse, use of sedatives and oral narcotics, and a past alcohol problem. There are important demographic and clinical correlates with irritable bowel-type symptoms.
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PMID:Irritable bowel-type symptoms in HMO examinees. Prevalence, demographics, and clinical correlates. 835 67

In the former western part of Germany, in 1989 about three million people claimed social costs because of urinary incontinence. 80 percent of them were women. The psychic situation of these women is mainly determined by social consequences of their incontinence. Behavioural changes to avoid incontinence lead to social isolation. A coherence between incontinence or urgency and agony or depression is acknowledged. Especially in elderly people, who have to change their well-known environment due to nursing problems, incontinence is a major problem, which often deteriorates with the new situation. Incontinence also leads to avoidance of sexuality. Women are mostly more irritated than their partners. On the other hand incontinence is used to avoid sexuality and thus may be a sign of a sexual conflict.
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PMID:[The psychological status of the female with urinary incontinence]. 836 33

This prospective randomised study involved 52 female patients suffering from recurrent stress urinary incontinence, objectively confirmed by means of clinical incontinence tests and urodynamic examinations. They alternatively underwent colposuspension according to Burch or suburethral sling procedure surgery. Urodynamic and sonographic examinations were carried out before and 2.5 years (i.e. within a range of 2-3) after surgery according to Burch or suburethral sling procedure. There was no significant difference between the two methods with respect to subjective and objective rate of cure, which amounted to 85% of the cases involving colposuspension and 88% of cases involving the suburethral sling procedure. Both methods resulted in a significant improvement of the depression quotient and a significant elevation of the internal urethral meatus (p < 0.05). Apart from an aggravation of urge symptoms in both groups, the patients with surgery according to Burch tended towards enterocele and rectocele in the medium range, whereas urination disorders had to be accepted in the patients operated on according to the sling procedure in the long term.
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PMID:[Surgical treatment of recurrent stress incontinence: Burch versus lyodura sling operation--a prospective study]. 837 Apr 87

Scientific studies investigating the postpartum period are scarce, and observational studies greatly outnumber controlled trials. Many studies are biased in their assumptions about the social roles of women and men and in the interpretation of observations and treatment strategies. The published literature is fragmentary; few researchers have attempted a comprehensive, biopsychosocial system-oriented view of postpartum health. More research is needed on the occurrence and treatment of such common postpartum problems as urinary incontinence, sexual dysfunction, and back pain. Widespread application of what is already known about support for breast-feeding, prevention of fatigue and depression, contraception, and maintenance of healthy lifestyles will require innovations in healthcare delivery, professional practices, and social policy, particularly in the occupational arena. Many postpartum problems have been found to be iatrogenic and responsive to changes in the routine care of mothers and newborns. Finally, it is clear that women of lower education and socioeconomic status and those with less social support are consistently at higher risk for postpartum and parenting problems; great benefits are likely from interventions that enhance the well-being of these mothers and infants.
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PMID:Postpartum care and breast-feeding. 837 63

To ensure the maximum quality of life for the elderly, practitioners must be precise in their evaluations. Physiologic aging decreases the reserve of the geriatric patient, making him or her more susceptible to the stress associated with illness, drugs, and surgery. Medications must be prescribed in reduced dosages to compensate for altered pharmacokinetics and pharmacodynamics in the elderly. Musculoskeletal problems, cardiovascular diseases, malignancies, and visual and hearing impairments are seen frequently in this population. Cognitive failure, depression, gait instability and falling, and urinary incontinence may be caused by acute or chronic problems. A comprehensive assessment directed at medical, mental, social, and functional status problems is imperative.
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PMID:General concepts of geriatric medicine. 843 36

We report a case of spinal subdural haematoma with neurological deficit in a 36-yr-old woman following Caesarean section for severe preeclampsia and placental abruption. She had been taking chronic trifluoperazine treatment for depression. Her activated partial thromboplastin time (aPTT) was 49 sec (normal = 26-36) but all other tests of coagulation were normal. Epidural anaesthesia was attempted but, despite a negative test dose, injection of local anaesthetic resulted in a generalized seizure and general anaesthesia was induced. Seventy-two hours after delivery, she was found to have bilateral leg weakness, urinary incontinence, absent rectal sphincter tone and asymmetrical leg reflexes. The diagnosis of spinal haematoma was confirmed by magnetic resonance imaging. She underwent emergency laminectomy and made a full neurological recovery.
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PMID:Spinal subdural haematoma in a parturient after attempted epidural anaesthesia. 826 79

In a representative population of ambulant and home-dwelling 76-year-old citizens in Sweden (n = 565), dizziness was reported in about one third of the sample and more frequent in women. The dizzy subjects had more locomotor disorders, angina, urinary incontinence, stroke/paresis, and mental disorders than the non-dizzy. Unsteadiness was the most frequently reported sensation of dizziness and was more common in women than in men. Dizziness had a detrimental influence on all quality of life dimensions and daily life areas, as measured by the Nottingham Health Profile (NHP), except home life and, in women, social life. Dizzy subjects reported more frequently memory problems and anxiety than non-dizzy subjects. Dizziness showed a significant correlation with nervousness and depression in men. Dizziness seems to be one of the most important single symptoms with a negative influence on well-being in old age. It should be recognized as a serious complaint, especially in men, and, therefore, recorded in regular screenings in the elderly.
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PMID:Health-related quality of life and dizziness in old age. 864 3

Demographic trends reveal the elderly to be the fastest growing segment of the population. Physicians can therefore anticipate encountering increasing numbers of older patients with alcohol-related problems. These problems include liver disease, dementia, confusion (masquerading as dementia), peripheral neuropathy, insomnia, late-onset seizure disorder, poor nutrition, incontinence, diarrhea, myopathy, inadequate self-care, macrocytosis, depression, fractures, and adverse reactions to medications. Despite the prevalence of alcohol use in older people, their risks and problems are often unrecognized. We reviewed published literature on the determinants and consequences of alcohol-related problems in persons aged 65 years and older and the usefulness of available screening measures. Thirteen of 25 eligible studies on determinants and consequences met quality criteria and were reviewed. Nine additional studies on screening tests were also evaluated. Determinants include history of alcohol use and abuse, social isolation, and reduced mobility; consequences consist of risks of hip fracture from falls, neoplasms, and psychiatric illness. Currently accessible screening tests focus on high levels of alcoholic beverage use and abuse and dependence. They are not useful in screening for hazardous consumption that may result from relatively low levels of alcohol use alone or in combination with medications, medical illness, or preexisting diminished physical, emotional, or social function. Research is needed on the consequences of lower levels of alcohol consumption on the physical and psychosocial health of older individuals and on methods for distinguishing alcohol-related from age-related problems. Existing screening tests should be expanded or new screening methods developed in anticipation of a growing public health problem.
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PMID:Alcohol-related problems in older persons. Determinants, consequences, and screening. 900 85


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