Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

122 patients with urinary incontinence of all degrees and 32 controls are investigated by means of a complex urodynamic unit constructed by the authors. Essential part is a robust selfmade three-canal-catheter of heatsealed angiographic material with an external diameter of 10 Charr., which undamagedly can be used at least forty times. The unit enables to do cystometries and simultaneous cystourethrotonometries with electromyography of pelvic floor and mictiometries. The investigations are possible at a normal expense in lying or sitting and all intermediate positions. Many urometric parameters had been determined with aid of perfusion uromanometry according to the principle of Heidenreich and Beck. New combinations had been elaborated. The functional length of urethra in stress profile, the maximal urethral closing pressure, the electronically registered urethral closure pressure, the depression factor and the stress quotient are of special importance. By means of these criteria the qualification of the apparently old fashioned perfsuion uromanometry for a modern urodynamic diagnosis could be demonstrated. The results are compared with those obtained with microtransducer technique.
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PMID:[New aspects of the Heidenreich and Beck perfusion method in urodynamics. I: Practical experience with a complex urodynamic work station]. 661 98

The perfusion urethrotonometry was used in this study in 34 patients both in lying and upright position as paired comparisons. The following problems could be solved: 1. Using the complex urodynamic unit of the authors examinations are possible in vertical position successfully. 2. The urethral pressure profiles are equivalent qualitatively in both examination positions. 3. The analysis of the profiles of both positions on principles demonstrates the same valuation. In case of incontinence the relevant parameters for diagnosis (functional length of urethra in stress profile, electronically registered urethral closure pressure in stressful situation, transmission and depression factor and stress quotient) show clearer in the upright position than in the lying one. In continent women the change of position has no significant influence. If the criteria in lying position are not well defined, the urethral pressure profile in upright position should be done as additional examination.
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PMID:[New aspects of the Heidenreich and Beck perfusion method in urodynamics. II: Effect of examination position on parameters of urethral pressure profile]. 668 74

The quality of life for patients with carcinoma of the lower two-thirds of the rectum (5-12 cm from the anal verge) treated by abdominoperineal resection (APER, n = 38) was compared with that of a similar group of patients treated by low sphincter saving resection (SSR, n = 40). Assessment was by questionnaire conducted a minimum of one year after operation. Thirty patients (75 per cent) after SSR were entirely continent and ten patients (25 per cent) had occasional episodes of incontinence. Each patient with a colostomy was incontinent and 25 (66 per cent) had leaks from their appliance (12 frequent; 13 occasional). Patients after APER avoided more items in the diet and took more medication to control their bowel habit than patients after SSR. Fifteen of the 18 patients (83 per cent) who were employed before SSR returned to work after operation; only 6 of 15 patients (40 per cent) returned to work after APER (P less than 0.05). Sexual function was impaired in 6 of 20 men (30 per cent) after SSR and in 12 of 18 men (67 per cent) after APER (P less than 0.06). Depression was significantly more prevalent after APER than after SSR. Patients with low rectal cancer who are treated by modern sphincter saving resection have a quality of life superior to those who are treated by APER.
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PMID:The quality of life after rectal excision for low rectal cancer. 687 35

Wistar rats, both male and female, were treated with aclacinomycin A at 4 dosage levels (0.375, 0.75, 1.5 and 3.0 mg/kg/day) by daily intraperitoneal injection for 30 days. Several rats died in the two higher dose groups (1.5 mg/kg/day: male 2/8 and 3.0 mg/kg: male 8/8, female 8/8. Piloerection, anorexia, depression of spontaneous activity, diarrhea and slight incontinence were observed in rats in 3.0 mg/kg/day dose group. Body weight gain decreased after day 3 in rats receiving 1.5 and 3.0 mg/kg/day. A significant decrease in the total WBC count and a slight decrease in RBC count were observed in animals of 1.5 mg/kg/day dose group which were survived for 30 days. Autopsy findings demonstrated atrophy of the thymus and spleen, and hyperemia and hemorrhage in the intestine. The atrophy of the thymus and decreased hematopoiesis in the bone marrow were histologically noted in the two highest dose groups. No cardiotoxicity was observed.
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PMID:[Subacute toxicity of aclacinomycin A in rats (author's transl)]. 692 58

The case of a 61-year-old woman with an apathetic depression and urinary incontinence is presented. Her depression and urinary incontinence were symptomatically treated with d-amphetamine prior to diagnosis of bilateral frontal lobe meningiomas. Similar but irreversible neurologic conditions might be successfully treated by using amphetamines.
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PMID:Frontal lobe meningioma and depression. 708 82

Idiopathic faecal incontinence in middle-aged people has been found to be commonly associated with neurogenic damage to the anal sphincter musculature. Because neurogenic atrophy of skeletal muscle is a common feature of ageing, we have investigated the possibility that faecal incontinence in elderly people might be due to age-related denervation of the anal sphincter musculature. The technique of single fibre electromyography was used to measure the motor unit fibre density in the external and sphincter muscle in ten patients aged 78 to 99 years. Those patients whose continence was impaired had a markedly increased fibre density. Our findings suggest that neurogenic damage to the anal sphincter musculature may so reduce its functional reserve in elderly people that incontinence occurs when other factors, such as looseness of stool or depression of cerebral function, co-exist.
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PMID:A neurogenic factor in faecal incontinence in the elderly. 712 56

By psychophysiologic training of internal and external rectal sphincters five incontinent subjects managed to recover a complete or incomplete self-control in very difficult situations, such as outcomes of surgical sphincter lesions, depression equivalents and ischemic nervous sufferings. So anus incontinence (perhaps preternatural anus incontinence) could be faced by means of biofeedback, especially if similar home sessions were associated.
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PMID:[Biofeedback in fecal incontinence]. 743 66

We aimed to study the impact of conservative non-pharmacological, non-surgical management on quality of life in elderly incontinent patients. Community-dwelling patients age 60 years or older were randomized to receive immediate or delayed conservative management. A number of questions relating to quality of life were administered at admission and then at 2, 4, 8 and 12 months. By 4 months, incontinence was cured in 25% and improved in 63% of patients. The frequency and severity of incontinence was reduced (p < 0.001), and deferment time was improved (p < 0.01). There were statistically significant improvements in subjective quality of life measures at 4 and 12 months involving depression (p < 0.001), isolation (p < 0.03), embarrassment (p < 0.001), laundry (p < 0.001) and smell (p < 0.02) when comparing these variables with initial assessment. This effect did not appear to be a placebo effect as evidenced by comparison with the delayed intervention group, and was sustained over 12 months. There are significant short- and long-term benefits to the quality of life of older patients with incontinence when treated by conservative measures. Intervention studies should measure and report quality of life as an outcome variable.
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PMID:Sustained improvement of subjective quality of life in older community-dwelling people after treatment of urinary incontinence. 748 83

Two patients who incurred significant injuries during psychogenic seizures prompted us to do a telephone survey of self-injury and incontinence in 102 consecutive patients diagnosed with psychogenic seizures by EEG-closed-circuit TV (EEG-CCTV) monitoring. Seventy-three patients (or a close family member or friend) were reached by telephone and responded to our survey. During typical attacks of psychogenic seizures, 40% reported injuries, 44% reporting tongue biting, and 44% reported urinary incontinence. Suicide attempts were reported by 32% and were more common in those with self-injury and urinary incontinence. We compared the results of patients with psychogenic seizures with those of 30 patients with refractory epilepsy documented by ictal recordings, using a similar telephone survey. Injuries of all types were more commonly reported by epilepsy patients. Burn injuries were reported only by patients with epilepsy. Suicide attempts were more commonly reported by the psychogenic seizure group. Self-injury and incontinence are commonly reported by psychogenic seizure patients. In view of their significant association with suicide attempts, they may indicate an underlying depression.
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PMID:Self-injury and incontinence in psychogenic seizures. 755 72

Urinary incontinence (UI)--the involuntary loss of urine sufficient to be a problem for the patient or caregivers--affects an estimated 15%-30% of persons aged > or = 60 years in the United States and is a major cause of admittance to nursing homes. UI may be associated with a variety of medical (e.g., rashes, skin infections, pressure sores, urinary tract infections, and falls) and psychosocial problems (e.g., depression, embarrassment, restricted social interaction, reduced activities outside the home, reduced sexual activity, and sleep disturbances). Despite the dissemination of clinical practice guidelines for UI by the Agency for Health Care Policy and Research (AHCPR), many physicians do not know how to diagnose or treat UI. Beginning in 1992, CDC and AHCPR funded demonstration projects in Massachusetts and Oklahoma to educate the public, patients, and health-care professionals about UI. In both projects, physicians were assessed regarding baseline attitudes toward UI, knowledge of the causes and treatment of UI, preparedness to evaluate and treat UI, and current practices regarding UI. This report summarizes findings from the two projects during 1993.
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PMID:Knowledge, attitudes, and practices of physicians regarding urinary incontinence in persons aged > or = 65 years--Massachusetts and Oklahoma, 1993. 756 56


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