Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two cases of early ulcerative syphilis observed in the city of La Plata, Argentina, in the last 13 years are presented. Cases n.o 1, classified as Queyrat type, was in a previously bad general condition, due both to excessive smoking and alcoholism and showed a classic blood serologic test, that was slightly reactive. Case n.o 2, Milian type, presented a previously excellent general condition. The classic blood serologic test and FTAabs. were strongly reactive. It showed only a significant depression of cell immunity, with regard to the bacterial cutaneous proofs (bacterial skin-tests) carried out "in vivo". In both cases the clinical aspect was similar, with ulcerative necrotic lesions and affectation of the general condition which coincided with the outbreak of those lesions. The response to treatment was good, with rapid improvement of the general condition while the improvement of the skin lesions was slower and occurred only within 3 weeks.
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PMID:[Early or malignant ulcerative syphilis. Considerations apropos of 2 cases. Bibliographic analysis]. 35 59

Peripheral blood lymphocytes isolated from rabbits in the early stages of Treponema pallidum infection responded poorly when exposed to concanavalin A in vitro. Maximal depression of blastogenesis occurred when lymphocytes were cultured in the presence of autologous serum in comparison with fetal calf or normal homologous rabbit serum.
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PMID:Depression of lymphocyte response to concanavalin A in rabbits infected with Treponema pallidum (Nichols strain). 78 Feb 77

A-50-year-old woman was admitted to our hospital for the examination of exertional chest pain. She had no coronary risk factors. No hormonal disorders were observed. Physical and laboratory examinations revealed that she had not suffered from syphilis or aortitis syndrome or any other inflammatory diseases. An exercise electrocardiogram (Master's test) demonstrated ST segment depression in V3-6, II, III and a VF. On coronary angiography, a 75% stenosis of the left coronary ostial stenosis was found, but no abnormality was found in other arterial trees. The patient was diagnosed as having isolated coronary ostial stenosis. She underwent coronary bypass surgery from the aorta to the circumflex artery and the anterior descending coronary artery. She is now completely asymptomatic. A review of the literature together with this patient reveals the following characteristics of patients with isolated coronary ostial stenosis. Firstly, the patients are almost always middle aged woman with no coronary risk factors. Secondly, the involved coronary artery is the left main coronary artery, so its obstruction results in a serious condition. Therefore, though its pathogenesis remains to be determined, isolated left coronary ostial stenosis seems to be a distinct clinical entity.
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PMID:[A case of middle aged women with isolated left coronary ostial stenosis]. 143 94

Many studies of age-related cognitive decline have failed to distinguish between usual and successful aging. Although some degree of cognitive impairment is associated with aging, when one looks at average performance, there is great variability among individuals, with many showing little or no deleterious effects of aging on intellectual abilities. Many of the risk factors for dementia and for conditions associated with cognitive impairments can be treated or controlled. Among the preventable causes of cognitive decline are the following: AIDS, Alcohol and drug abuse, Cerebrovascular disease, Exposure to organic solvents or lead, Head trauma, Overmedication, Syphilis. Other conditions that may cause cognitive decline can be controlled or treated: Atherosclerosis, Depression, Diabetes, Emphysema, High blood pressure, Obesity, Sleep disorders, Thyroid dysfunction. In addition, it may be possible to enhance the cognitive performance of even healthy elderly people through changes in diet and lifestyle. Recent data raise the possibility that improved prenatal and perinatal care and greater access to educational opportunities may result in a decreased incidence of dementia in future generations of older adults. Although they are rapidly becoming more numerous, the efficacy of cognitive training programs in preventing or slowing cognitive decline has not yet been demonstrated. Nevertheless, such programs may ameliorate cognitive impairment by reducing the psychiatric disabilities associated with anxiety and depression. The general principle underlying these strategies for limiting cognitive impairment with age is to maximize brain reserve and minimize brain damage.
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PMID:Preventing cognitive decline. 157 76

The diagnostic evaluation of dementia is directed toward the identification of treatable causes. It can be facilitated by classification of the dementia into one of four categories: attentional, amnestic, cognitive, and intentional. Intentional dementia reflects dysfunction of frontal lobe systems, components of which include the frontal cortex, basal ganglia, thalamus, limbic structures, and subcortical white matter. Disorders that affect one or more of these components and produce intentional dementia include Binswanger's disease, Parkinson's disease, Huntington's disease, HIV infection, closed head injury, normal pressure hydrocephalus, neoplasms, syphilis, vitamin B12 deficiency, multiple sclerosis, and a number of uncommon degenerative and acquired syndromes. Depression may resemble intentional dementia. Guidelines for diagnosis and management are discussed.
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PMID:Multi-infarct dementia, subcortical dementia, and hydrocephalus. 203 8

Sustained antigenic stimulation following intravenous infection of rabbits with Treponema pallidum results in antibody responses and the formation of immune complexes. Complexes in greater than 300 sera from normal rabbits and from animals with experimental syphilis were measured by Raji cell and polyethylene glycol-complement consumption assays. Profound increases in both the incidence and levels of immune complexes were seen between the third and seventh weeks of infection. Single radial immunodiffusion studies revealed moderate increases in immunoglobulin levels and depression of C3 levels during the third and fourth weeks of infection. Penicillin treatment was followed by normalization of C3 levels and clearance of immune complexes. Lower levels of complexes in the sera of intradermally infected rabbits and the absence of immune complexes in intratesticularly infected animals suggest that immune complexes in the circulation may be related to the extent and severity of cutaneous involvement.
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PMID:Immune complexes in experimental syphilis: a methodologic evaluation. 676 62

There are marked similarities in the psychiatric disorders associated with autoimmune deficiency syndrome (AIDS) and syphilis (paresis). Although depression is most common, the psychiatric disorders in both conditions include the entire range of clinical syndromes that can simulate any type of mental disorder, functional or organic. The underlying neuropathology and methods of transmission are also similar. The author also notes that the social and moral attitudes toward patients with AIDS and syphilis are alike, including moral and religious prohibitions against the use of condoms.
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PMID:Similarities of psychiatric disorders of AIDS and syphilis: history repeats itself. 792 Mar 75

An investigation of the induced suppression and cytotoxicity of T lymphocytes, carried out in 57 patients with different forms of syphilis, has made it possible to find some reasons for the depression of cell-mediated immunity (CMI) in patients with early syphilis. The analysis of the immunoreaction of patients with different forms of syphilis clarifies the influence of the human immunodeficiency virus (HIV) on the dynamics and formation of syphilis manifestations.
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PMID:Immunosuppression in patients with syphilis and problems of human immunodeficiency virus infection. 797 99

In order to examine the character and phases of injury to the nervous system in HIV infection, 207 persons were observed. In 100, antibodies to the virus and to its separate proteins were discovered by immunofermentation analysis (IFA) reaction and by Western blot test. In 67, first phases of acute inflammation asymptomatic of persistent generalized lymphadenopathy were registered; and in 33, other ailments were found. In this group, which consisted of 74 men and 26 women aged 18-45, 91 were citizens of the Community of Independent States (15 of whom had served in the military) and 9 were citizens of other countries (4 had seen military duty). 75% of cases contracted the infection via sexual transmission. The control group comprised 65 seropositive people at the first screening confirmed by IFA but negative or doubtful by Western blot. Clinical laboratory and special psychological investigations were carried out using a 16-factor personality questionnaire and standard personality analysis methods. Generalized lymphadenopathy was found in 78%, hepatomegaly in 69%, chronic infection of the upper respiratory tract 67%, dermatological pathologies 33%, acute infections 32% (syphilis, hepatitis B), splenomegaly 20%, diarrhea and loss of more than 10% of body mass 11%. There was significant decrease of T-helper cells in 82.8%, in the correlation of the quality of T helper cells and T suppressor cells in 72.4%. In 67 persons who were in the second stage of HIV infection, there was a high frequency of pathological psychological symptoms. According to the personality scale, 60% had schizoid signs, 50% had depression, 40% had psychopathy, 30% had psychasthenia, and 20% had paranoia. When 33 persons in the second and third phase of the disease were measured, schizoid signs increased to 85.7%, depression to 78.6%, psychopathy to 57.1%, psychasthenia to 71.4%, and paranoia to 64.3%. In the first phases of the disease mainly hypochondria, depression, and hysteria predominated, and as the disease progressed, psychopathy, paranoia, psychasthenia, schizoid signs, and mania rose.
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PMID:[HIV infection: the clinical and expert diagnostic aspects]. 817 5

Coronary ostial stenosis with otherwise normal coronary vessels occurs in patients with syphilis or Takayasu's aortitis. Iatrogenic ostial stenosis may develop as a complication of coronary angiography or after coronary perfusion at the time of cardiac surgery. Isolated ostial stenosis in the absence of these factors has been reported infrequently and its unique clinical and angiographic profile has been noted recently. Hence, it is proposed that this type of isolated ostial stenosis may represent a clinical entity distinct from the usual atherosclerotic coronary disease. We report the case of a middle-aged woman with this type of isolated coronary ostial stenosis. A 55-year-old female was admitted with the complaint of exertional chest pain, which had appeared 2 months admission and which had gradually become more frequent. The ECG on admission was normal. She had no coronary risk factor. Treadmill exercise test was stopped at stage 2 of Bruce protocol because ischemic S-T segment depression appeared in II, III, aVF, V4-V6 and she complained of a chest pain. Coronary angiography showed a 90% stenosis of the left coronary ostium with normal distal vessels. The right coronary artery was normal. A coronary artery bypass graft to the left anterior descending branch was performed uneventfully and the patient remains asymptomatic.
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PMID:[A case of isolated coronary ostial stenosis in a middle-aged woman]. 833 37


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