Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Patients with post-traumatic stress disorder (PTSD) often encounter treatment that is complicated by professional bias, personal issues, countertransference, and pathological staff dynamics. 2. Treatment is further complicated by diagnostic confusion, the dual diagnoses of substance abuse or depression, and symptoms that mimic personality disorders or psychosis. 3. The special circumstances of the Vietnam conflict that contributed to the susceptibility and etiology of PTSD are the individual characteristics of those who served, the special nature of the war itself and the military strategies used, and the psychosocial and cultural milieu in which it occurred.
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PMID:PTSD and the Vietnam veteran: the battle for treatment. 194 21

Rape victims with posttraumatic stress disorder (PTSD; N = 45) were randomly assigned to one of four conditions: stress inoculation training (SIT), prolonged exposure (PE), supportive counseling (SC), or wait-list control (WL). Treatments consisted of nine biweekly 90-min individual sessions conducted by a female therapist. Measures of PTSD symptoms, rape-related distress, general anxiety, and depression were administered at pretreatment, posttreatment, and follow-up (M = 3.5 months posttreatment). All conditions produced improvement on all measures immediately post-treatment and at follow-up. However, SIT produced significantly more improvement on PTSD symptoms than did SC and WL immediately following treatment. At follow-up, PE produced superior outcome on PTSD symptoms. The implications of these findings and direction for treatment and future research are discussed.
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PMID:Treatment of posttraumatic stress disorder in rape victims: a comparison between cognitive-behavioral procedures and counseling. 195 5

The authors use six case vignettes to illustrate underrecognized complications occurring during flooding therapy for posttraumatic stress disorder (PTSD), including exacerbation of depression, relapse of alcoholism, and precipitation of panic disorder. A common denominator to the majority of these cases appears to be the mobilization of negative posttrauma appraisal, accompanied by shame, guilt, and anger. The authors suggest that flooding may not be helpful for these negative emotions in the manner that it is for anxiety. Suggestions for preventing and treating complications of flooding therapy for PTSD include employing more cognitive forms of therapy in cases at risk; supporting abstinence from alcohol and other substances; providing adjunctive pharmacologic treatment as indicated, e.g., tricyclics for depression or panic; and providing long-term follow-up.
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PMID:Psychiatric complications during flooding therapy for posttraumatic stress disorder. 198 12

To ascertain the prevalence of posttraumatic stress disorder (PTSD) and risk factors associated with it, we studied a random sample of 1007 young adults from a large health maintenance organization in the Detroit, Mich, area. The lifetime prevalence of exposure to traumatic events was 39.1%. The rate of PTSD in those who were exposed was 23.6%, yielding a lifetime prevalence in the sample of 9.2%. Persons with PTSD were at increased risk for other psychiatric disorders; PTSD had stronger associations with anxiety and affective disorders than with substance abuse or dependence. Risk factors for exposure to traumatic events included low education, male sex, early conduct problems, extraversion, and family history of psychiatric disorder or substance problems. Risk factors for PTSD following exposure included early separation from parents, neuroticism, preexisting anxiety or depression, and family history of anxiety. Life-style differences associated with differential exposure to situations that have a high risk for traumatic events and personal predispositions to the PTSD effects of traumatic events might be responsible for a substantial part of PTSD in this population.
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PMID:Traumatic events and posttraumatic stress disorder in an urban population of young adults. 199 17

A survey study was conducted on the psychosocial readjustment of 164 of the estimated 10,000-40,000 Canadians who served in Vietnam with the U.S. military. Results indicate significantly greater rates of posttraumatic stress disorder (PTSD) compared with U.S. Vietnam veterans. Evidence of other psychosocial adjustment problems such as depression, inability to handle frustration and anger, difficulty in getting along with and trusting others, and family and marital problems, as well as poor physical health, was also found. Results suggest these problems are due, in part, to prolonged isolation from other Vietnam veterans, lack of recognition, and no readily available treatment for PTSD in Canada.
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PMID:Psychosocial readjustment of Canadian Vietnam veterans. 200 37

To characterize the effects of trauma sustained more than 40 years ago, prevalence of psychiatric disorders and personality dimensions were examined in a sample of 62 former World War II POWs. The negative effects of their experiences are reflected in their multiple lifetime diagnoses and in their current personality profiles. Fifty percent met DSM-III posttraumatic stress disorder (PTSD) criteria within 1 year of release; 18 (29%) continued to meet the criteria 40 years later at examination (chronic PTSD). A lifetime diagnosis of generalized anxiety disorder was found for over half the entire sample; in 42% of those who never had PTSD, 38% of those with recovery from PTSD, and 94% of those with chronic PTSD. Ten percent of those without a PTSD diagnosis had experienced a depressive disorder, as had 23% of those with recovery from PTSD and 61% of the POWs with chronic PTSD. The combination of depressive and anxiety disorders also was frequent in the total sample (61%). Current MMPIs of three groups with psychiatric diagnosis were compared with those of POWs who had no diagnoses and with a group of Minnesota normal men. Profile elevations for the groups, from highest to lowest, were: POWs with chronic PTSD, POWs with recovery from PTSD, POWs with other psychiatric diagnoses, POWs with no disorders, and Minnesota normal men. Symptoms of anxiety, depression, and somatic concerns combined with the personality styles of suppression and denial characterize the current adjustment of negatively affected POWs.
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PMID:Comorbidity of psychiatric disorders and personality profiles of American World War II prisoners of war. 200 87

The present report describes the development of the Penn State Worry Questionnaire to measure the trait of worry. The 16-item instrument emerged from factor analysis of a large number of items and was found to possess high internal consistency and good test-retest reliability. The questionnaire correlates predictably with several psychological measures reasonably related to worry, and does not correlate with other measures more remote to the construct. Responses to the questionnaire are not influenced by social desirability. The measure was found to significantly discriminate college samples (a) who met all, some, or none of the DSM-III-R diagnostic criteria for generalized anxiety disorder and (b) who met criteria for GAD vs posttraumatic stress disorder. Among 34 GAD-diagnosed clinical subjects, the worry questionnaire was found not to correlate with other measures of anxiety or depression, indicating that it is tapping an independent construct with severely anxious individuals, and coping desensitization plus cognitive therapy was found to produce significantly greater reductions in the measure than did a nondirective therapy condition.
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PMID:Development and validation of the Penn State Worry Questionnaire. 207 86

The process of international migration has been associated with increased levels of psychological disturbance and recently investigators have noted the experience of PTSD symptoms among recent war refugees from Southeast Asia. This study sought to first examine the overall impact of migration in a large sample of immigrants from Central America and Mexico in terms of symptoms related to depression, anxiety, somatization and generalized distress. A second aim of the study was to note the existence of specific symptoms related to PTSD diagnoses as related to self-reported reasons for migration. Immigrants were found to have overall higher levels of generalized distress symptoms when compared to non-immigrants, and self-reported reasons for migration were highly related to PTSD diagnosis, with 52% of Central American war refugees in this sample meeting the DSM-III criteria for the disorder. Results are discussed in terms of sensitizing mental health professionals to the psychological sequelae of forced migration.
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PMID:[Migration and post-traumatic stress disorders: the case of Mexicans and Central Americans in the United States]. 210 50

The prisoner of war (POW) experience is greatly influenced by the environmental and sociocultural factors of the particular captivity setting. Among the most important coping mechanisms are communication, maintenance of military social structure, and personality flexibility. Following repatriation some former POWs develop psychiatric disorders, most commonly 1) medico-psychiatric disorders due to illness, physical trauma, or nutritional deficit, 2) post-traumatic stress disorder, 3) adjustment disorder, 4) depression, 5) anxiety disorders, 6) substance use disorders, and 7) family problems. The severity of captivity and the presence or absence of social supports during and after the POW experience play major roles in the recovery or illness that may occur after repatriation.
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PMID:The prisoner of war. 211 Mar 41

Posttraumatic stress disorder (PTSD) may develop after exposure to severe stress, such as combat, accidents, assaults, and natural disasters. Pharmacotherapy can be a useful adjunct in the comprehensive treatment of these patients. The presence of comorbid conditions, including depression, panic disorder, substance abuse, and traumatic brain injury, should be carefully evaluated. Symptoms of PTSD that are associated with central nervous system hyperarousal or reexperiencing of the traumatic event appear to be the most responsive to pharmacotherapy. Social withdrawal and dulled responsiveness have not been shown to be alleviated through standard pharmacologic interventions. A therapeutic strategy is proposed that is based on the patient's symptoms and initial response to medication.
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PMID:New approaches in the pharmacotherapy of posttraumatic stress disorder. 212 Feb 3


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