Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A complex clinical and psychological examination of three groups of patients with stable neurological deficit (113 subjects, 77 men and 76 women, aged from 19 to 67 years) included those with multiple sclerosis (MS), chronic cerebral vascular disorders and chronic dorsopathy with illness duration 5-7 years has been carried out. Neuropsychological status and quality of life were assessed using the following tests: Medical Outcomes Study Short Form 36 Health Survey (SF-36); the method of E.B. Fantalova "Level of Ratio of "Values" to "Availability" in Different Life Spheres", Integrative Anxiety Test, Manual for the Constructive Thinking Inventory, Coping test (Lazarus), Beck depression scale. In total, 42 traits on 6 tests have been studied. The study was conducted before and after treatment (21 +/- 2 days). The results revealed that patients with chronic neurological disorders, in particular with MS, often had subclinical depression, which negatively influenced the disease course, and needed treatment. A high level of anxiety was found in MS patients that was related to situational social defensive reaction. Low ability to positive reevaluation of life situations, one of the causes of anxiety states, was observed in all the groups, especially in MS. In MS patients, their real state was not consistent with their perception of this state. They also were featured by personal superstitious thinking. Most of the patients with MS had a good constructive thinking, preserved ability to emotional and behavioral self-control that indicated favorable prognosis in future complex rehabilitation. After the course of symptomatic vascular and metabolic therapy, with the exception of antidepressants and neuroleptics, the appearances of depression and anxiety as well as expression of social defensive reactions and situational phobic component of anxiety were decreased that suggested the necessity of inclusion of individual psychotherapy as a part the complex rehabilitation therapy.
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PMID:[The possibilities of adaptation of patients with multiple sclerosis: the results of clinical and psychological study]. 1717 38

An open comparative study of efficacy and tolerability of velaxin (venlafaxine with prolonged action), which has been prescribed in a single dosage of 75 mg daily during 8 weeks, included 47 patients with subacute and chronic spondylogenic dorsopathy (SD). Degree of pain chronisation and its intensity (The Visual Analogous Scale - VAS and the Verbal Pain Scale - VPS) and levels of daily activity restriction (the modified Pain Disability Questionnaire - PDQ), anxiety and depression were measured. The comparison group consisted of 32 patients with SD matched for clinical characteristics with the main group, who did not receive antidepressants and antiepileptics in the complex treatment of pain syndrome. Scores of VAS, VPS and PDQ in the main group were 69+/-2.9; 2.8+/-0.1 and 44.2+/-3.2 respectively, at baseline; 38.8+/-3.3 (p<0.01); 1.6+/-0.2 (p<0.01) and 26.2+/-2.5 (p<0.01) after 4 weeks and 15.8+/-2.5 (p<0.05); 0.6+/-0.1 (p<0.05) and 11.2+/-1.6 (p<0.01) to the end of treatment. To the 8th week, scores on VAS, VPS and PDQ were significantly low in the main group compared to the controls (p<0.5) and the intensity of pain was reduced by 50% in 40 (85%) patients. No serious side-effects were observed.
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PMID:[Results of a study of velaxin (venlafaxine) efficacy in patients with subacute and chronic spondylogenic dorsalgia]. 1949 16

A comprehensive survey of 78 patients with chronic vertebral low back pain was conducted. Among them were 23 (29,5%) patients with radiculopathy and 55 (70,5%) patients with reflex syndromes without exacerbations. It was shown that patients with compressive syndromes of lumbar dorsopathy were characterized by the high intensity of pain, pronounced neuropathic pain component, lower quality of life as well as the significantly low serum serotonin content that was correlated with the degree of neuropathic pain severity and depression level.
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PMID:[Clinical and biochemical mechanisms of the formation of chronic low back pain]. 2202 72