Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Of 61 cases of ibuprofen overdosage reported consecutively to the Rocky Mountain Poison and Drug Center from September 1985 through April 1986, 16 were excluded because of incomplete follow-up or concurrent medication ingestion. A toxic reaction developed in 7 (16%) of the remaining 45 patients. Nausea, vomiting, abdominal cramps, mild central nervous system depression, coma, tachycardia, apnea, metabolic acidosis with or without respiratory alkalosis, hematemesis, and oliguric renal failure were noted. Two of six adults had a toxic reaction, and one died. Among pediatric patients, 5/39 (13%) had a toxic reaction. Of patients whose ibuprofen ingestion was less than 104 mg per kg, none became ill. All patients in whom the time of ingestion was known (six of seven) and who had a toxic reaction did so within four hours of ingestion. An ibuprofen overdose, although usually benign, can occasionally produce serious toxicity.
West J Med 1988 Jun
PMID:Ibuprofen overdose--a prospective study. 317 71

Lassa fever is widespread in West Africa, where the case fatality is about 16% in hospitalized adult patients. The clinical course is highly variable, with a few patients developing severe disease with bleeding, adult respiratory distress syndrome, encephalopathy and hypovolemic shock. We studied 70 patients admitted with suspected Lassa fever to a hospital in Sierra Leone, West Africa. Fourteen patients classified as having severe Lassa fever on the basis of serum aspartate amino transferase (AST) greater than 150 IU/L or viremia of greater than 10(3.6) tissue culture infective dose (TCID) 50/ml were found to have statistically significantly depressed lymphocyte counts when compared with patients with mild Lassa fever (AST less than 150 IU/L or viremia, less than 10(3.6)TCID50/ml), (P less than 0.0001) and with febrile control patients, in whom Lassa infection had been excluded by laboratory criteria (P less than 0.0008). Maximum depression occurred a mean of 10.9 days post onset. Patients with severe Lassa fever also had moderate thrombocytopenia, which was statistically significant when compared with febrile control patients (P less than 0.0003) and this occurred a mean of 10.8 days postonset. The most significant changes were in platelet function, which was markedly depressed in patients with severe Lassa fever (P less than 0.0035 in response to ADP and P = 0.0081 for collagen) when compared with patients with mild Lassa fever, and when compared with febrile controls, (P = 0.0013 for ADP and P less than 0.00001 for collagen). This abnormality was usually maximal on admission to hospital, and probably is an early event, preceding hospitalization in these patients.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Hematologic dysfunction in Lassa fever. 318 37

Past studies have reported consistent depression of birthweight among offspring of mothers who smoked during pregnancy, but depression of maternal weight gain and increase in perinatal mortality have been inconsistent; these have been generally associated with smoking among women of low social status. Among 8,263 pregnancies in West Jerusalem from 1974 to 1976 to women who were not religiously observant, birthweight was low among infants of smokers, but maternal weight gain was not depressed nor was perinatal mortality increased. Thus, the experience of these women in Jerusalem was similar to that of continental European, and affluent British and North American women. There appears to be no inevitable link between maternal smoking and depressed weight gain, nor with markedly increased perinatal mortality (however, since numbers of deaths were small, this observation requires replication). These results are consistent with the possibility that sustained weight gain among smokers may have contributed to the suppression of an effect of maternal smoking on increased perinatal mortality.
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PMID:Perinatal outcome, maternal weight gain, cigarette smoking and social status in Jerusalem. 318 44

On grounds of the literature about significant others of psychiatric patients it is to look for by what kind of characteristics different groups of significant others (mothers, spouses, others) may be differentiated and which variables characterize confident relationships and bonds. Significant others of psychiatric patients were investigated as well as the patients who belong to the diagnostic groups schizophrenia, depression or mania (RDC-criteria). They were investigated during and after an inpatient stay in one of the three psychiatric inpatient treatment centers in a large city of West Germany. For data analysis correspondence analysis was used, a method which is able to show correspondence between several characteristics by a computational as well as graphical way. Results show particularly two groups of significant others: burdened mothers and partners of depressed or manic patients. A confident relationship exists if daily contact was given as well as feeling attached to the patient and feeling burdened. Maintaining a confident relationship in spite of burden is explained by cognitive processes of attachment.
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PMID:[Trusting relations in family members of psychiatric patients]. 324 1

The parasuicide phenomena was investigated for the first time in a retrospective and prospective way in an Arab industrial community in the Eastern Province of Saudi Arabia during 1985 and 1986. Though the parasuicide rate of 20.7 per 100,000 is substantially lower from the reported rates in the West, underreporting and misdiagnosing of the phenomena may explain the low rate. The results of this study confirm that the act is predominantly the activity of young females, and disordered interpersonal relationships with spouses and parents stand out as precipitating factors. Acute reaction to stress was the commonest diagnosis followed by depression. Deliberate self-poisoning by analgesics and psychotropic drugs was the commonest method used. The findings of this study refute the hypothesis that parasuicide is rare in this part of the world, and time probably has come to amend the law in order to give the opportunity for distressed people to receive help.
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PMID:Parasuicide in an Arab industrial community: the Arabian-American Oil Company experience, Saudi Arabia. 326 83

From a survey of 281 house-staff members of a university medical center, we found that nearly half the respondents were afraid to complain about their training programs and were concerned that their relationship with their partner would not survive the residency. In all, 40% reported that anxiety or depression impaired their performance for a month or more; 12% reported an increased use of alcohol, marijuana, or cocaine; and 7% an increased use of sedatives, stimulants, or opioids. Stressors and dysfunctional behaviors did not differ significantly between male and female house staff, but many women had more tenuous support systems. Married house staff had stronger support systems and less substance abuse, anxiety, and depression. Departments differed widely in house-staff morale, available social supports, and the frequency of dysfunctional behaviors. Residency program directors should assess their house staff's distress and study and initiate means to reduce stress, increase support, and facilitate coping.
West J Med 1988 Jan
PMID:House staff well-being. 334 Nov 47

This paper reports on findings pertaining to levels of psychological distress, perceived health status, and physician utilization among a sample of Americans (N = 1204) and West Germans (N = 1266) living in Illinois and North-Rhine Westphalia, respectively. The conflicting perspectives of labeling theory and the clinical approach to cross-cultural variations in mental disorder are discussed. There were no significant differences between the two population groups with respect to anxiety tendencies or psychological distress generally, with the exception of Germans having significantly more tendency toward depression. In both countries, persons with the lowest expressions of anxiety were the most likely to perceive symptoms of physical problems as requiring a doctor's attention, thereby suggesting that anxiety operates to influence a denial of general readiness to deal with symptoms. Yet persons with the highest anxiety, depression, and overall psychological distress were most likely to report having experienced physical symptoms and visiting a doctor because of it. Persons with the highest anxiety, depression, and overall psychological distress also rated their health status the lowest.
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PMID:Psychological distress, perceived health status, and physician utilization in America and West Germany. 337 54

Neonatal EEG, cerebral evoked potentials, CT scan findings and their evolution were investigated in 42 neonates who eventually developed the West syndrome. In infants with perinatal hypoxia, the EEG displayed most often marked or maximal depression in the first week of life. The highly abnormal initial EEG improved progressively with time. The most frequent findings in early infancy was discontinuous tracing and persistent alternating tracing at 1-2 months, and absent sigma rhythms at 3-4 months. The VEP, AEP and CT scan also showed findings suggesting severe degree of brain damage. In infants with meningitis, the initial EEG was less depressed but the EEG abnormality persisted or worsened. In infants with prenatal causes the neonatal EEG was variable, ranging from a normal background EEG to specific abnormalities. The evolution of paroxysmal abnormalities was similar in all groups. There were no epileptiform discharges in early months. The appearance of hypsarrhythmia was preceded by focal and then multifocal spike or sharp wave discharges.
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PMID:Neurophysiological and neuroradiological features preceding infantile spasms. 343 14

Melancholy originally had another meaning from the present one. Only since the last century has melancholy taken on the meaning of severe depression. The Arabs were the first to introduce special wards for the mentally ill in their hospitals in the 8th and 9th centuries. In the West, mental wards in general hospitals have been known since the 13th century only. In the Renaissance dietary measures played an important part in the treatment of depression. Lean meat, fresh eggs, freshwater fish and particularly grapes were recommended. In the 17th and 18th centuries music therapy against depression came back into favour after being used in ancient times. In the 19th century opium was recommended and held its ground well into the middle of our century. Various methods and drugs were recommended and used for the therapy of depression in the 19th century, such as baths and massage, ferrous iodide, arsenic, ergot, strophantin, and cinchona. Actual antidepressants have been known only for approximately 30 years. The classic papers concerning therapy with lithium salts date back to the years 1948/49. It is a little known fact, however, that lithium salts had been used as prophylactic treatment against periodic depression 50 years earlier.
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PMID:[Historical notes on the therapy of depression]. 354 Nov 74

In China, the diagnosis of depression is made much less frequently than in the West, likely because there is a somewhat lower prevalence rate and because of other factors related to culture and to the development of Chinese psychiatry. Some of the relevant factors are: 1) depressed patients often avoid seeking help because of the stigma of mental disorder; 2) many patients seek help from practitioners of Traditional Chinese Medicine; 3) depression is often diagnosed as schizophrenia because of diagnostic criteria that are broader for schizophrenia and narrower for affective disorder than in the West; and 4) somatization is more frequent in China and many depressives receive the label "neurasthenia".
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PMID:Some issues in the diagnosis of depression in China. 365 79


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