Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Histological, histomorphometrical and histochemical data on the response of regional lymph nodes to tumor development, as recorded in experimental and clinical studies, were coordinated and supplemented by recent findings in experimentally induced autochthonous carcinomas in the rat gastrointestinal tract. The attempted correlation led to the definition of several prognostic parameters: 1) The development of germinal centers and the plasmocytic reaction in tumor draining nodes are morphological expressions of active humoral immune responses that may be specifically directed against the tumor. These reactions attain their maximum usually during late stages of tumor development. Their incidence and prognostic significance may vary depending upon the stage and the type of tumor. 2) Sinus histiocytosis is an immunologically nonspecific lymph node response with debatable prognostic significance. 3) Granulomatous sarcoid-like lesions may be understood as signs of an immunologically mediated antitumor response of macrophages activated by T lymphocytes. They are indicative of a favorable prognosis. 4) Paracortical hyperplasia, characterized by an increased population of lymphocytes and eventually immunoblasts, is an expression of an active T-cell reaction. This reaction occurs typically during early stages of experimental tumors. Correspondingly, it is of favorable prognostic significance in human tumors. 5) Lymphocytic depletion and nodular alteration of T-cell areas, with increased histiocytic infiltration, are reactions most often seen in the draining nodes of an advanced tumor. Both seem to coincide with depression of the cell-mediated immune reactivity. The present assessment of the reactive behavior of diverse lymph node compartments may serve as a first pointer to the proposed histologic immunostaging of malignant tumors.
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PMID:Lymph node reactions to cancer. 698 7

Patients with active sarcoidosis (acute and chronic) have a depression in systemic cell-mediated immunity manifested by a reduction in the number of circulating T cells and impaired responses of these cells to polyclonal mitogens and recall antigens. These abnormalities are absent in patients with resolved disease and contrast with heightened B-cell activity. The latter includes elevated serum immunoglobulins and the presence of autoantibodies and circulating immune complexes. Similarly, many humoral abnormalities (for example, immune complexes) are absent in patients with resolved disease. Studies of bronchoalveolar cells have revealed changes that are opposite to what is found in peripheral blood. The number of lymphocytes recovered by bronchoalveolar lavage is increased. This is mainly due to an increase in the number of T cells and a subpopulation of activated T cells. These findings suggest that the lung (when involved) is the site of an immune inflammatory response.
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PMID:Immunologic abnormalities in sarcoidosis. 698 31

Patients with active sarcoidosis have a depression in systemic cell-mediated immunity manifested by lymphopenia, a reduction in circulating T cells, and impaired responses of these cells to polyclonal mitogens and recall antigens. Studies of bronchoalveolar cells (BA) have disclosed characteristic changes in lymphocyte populations that are opposite to what is found in peripheral blood. Since previous lavage studies have not specifically addressed endobronchial disease, we present results of peripheral blood (PB) and BA lymphocyte studies in a patient with acute pulmonary sarcoidosis who had gross endobronchial nodules. The lymphocytosis in the BA air space of this patient was greatly increased compared with patients with newly diagnosed sarcoidosis but no overt endobronchial disease. Cell surface markers, morphology, and in vitro proliferative response indicated that the BA lymphocytes were stimulated and more reactive than PB lymphocytes, suggesting a local immune inflammatory response. Bronchial biopsy specimens showed mononuclear cell infiltration of the epithelium overlying the inflammatory nodules. The biopsy examination and great increase in lymphocytes recovered from the airways suggest that the bronchi were a source of the BA lymphocytes. Since clinically inapparent bronchial involvement is frequent in sarcoidosis, inflamed bronchi may also be a source of BA lymphocytes in the absence of conspicuous endobronchial nodules.
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PMID:Nodular endobronchial sarcoidosis: a study comparing blood and lung lymphocytes. 722 7

A retrospective evaluation of 244 electrocardiograms obtained at rest at time of diagnosis from a population of 254 patients with intrathoracic sarcoidosis was carried out. Thirty-five (14%) were abnormal. Sinus tachycardia was present in 17 (7%), the rest encompassing various degrees of right-sided bundle branch, atrioventricular first degree block, ventricular extrasystolia and ST-depression. At follow-up after a median time of 27 years we found a significantly higher mortality risk in the group with ECG-changes compared to those without. Excess mortality was increased when comparing patients with tachycardia to those without. However, when adjusted for FEV1, the risk of death was not significantly different between the two groups.
Sarcoidosis 1995 Mar
PMID:Electrocardiographic changes in patients with intrathoracic sarcoidosis: influence on prognosis. 761 75

Seventeen patients with diagnosed sarcoidosis were administered a number of psychological instruments to assess anxiety, depression, life stress, and symptoms of agoraphobia and/or panic. These patients were then followed medically for a period of nine months. Scores on the various psychological tests were then compared with results obtained from repeated pulmonary function tests. Results showed a consistent relationship between increased life stress at time one and impairment in lung function throughout the study period. In addition, no consistent set of psychiatric symptoms were associated with the disease. Sarcoid patients did, however, report many symptoms similar to patients with agoraphobia. These results are discussed in terms of the potential benefits of stress reduction treatment as an adjunctive therapy for patients with sarcoidosis.
Sarcoidosis 1993 Sep
PMID:Psychological factors in sarcoidosis: the relationship between life stress and pulmonary function. 814 Feb 97

The routine diagnosis of tuberculosis and other mycobacterial diseases based on organism identification was completed during a period of one year in 730 patients, with serological IgG, IgM and IgA determination of antibodies against antigen 60 from M. bovis , strain BCG. The analysis was performed on 10 groups of patients consisting of 1) inflammatory diseases of the respiratory tract, 2) pericarditis, myocarditis, lymphadenitis and CNS diseases, 3) chronic non-inflammatory diseases of kidneys, liver and pancreas, 4) non-inflammatory diseases of the heart, sarcoidosis and pneumoconiosis, 5) tumor, 6) healthy people with TB contact, 7) inactive TB, 8) culture-positive pulmonary and extra-pulmonary TB, 9) culture-negative TB and extra-pulmonary TB, and 10) potentially pathogenic mycobacteria. The specificity of the test (100% negative cases in Group 6, composed of healthy people) is estimated at about 90%, in accordance with determinations made in other laboratories. In non-tuberculous patients, the specificity varied according to the analysed groups. Group 1 was largely unspecific for IgM (76% positives) but the specificity was acceptable for IgG (6.2% positives ) and IgA (7.4% positives). Group 2 was similar to Group 1. Group 3 was associated with positive IgA titers. Group 4 was only exceptiony seropositive and Group 5 was positive mainly for IgA (11. 4%) associated with lower respiratory tract ailments. This unspecific seropositivity was attributed to inapparent infections by PPM whose colonisation was favored by the particular disease of the patients. The sensitivity of serological measurements applied to the diagnosis of TB patients and PPM patients was similar, regardless if the disease was pulmonary or non-pulmonary, regardless if cultures were positive or not and, in our hands, was low (positivity for IgA about 30 %, for IgM about 10% and for IgG about 30%). This poor sensitivity observed with people presenting for treatment is attributed to an immune depression occuring mainly in elderly patients. The remarkable sensitivity of the serological instrument applied to culture-negative pulmonary and non-pulmonary TB cases as well as PPM cases makes the test a good adjuvant in cases of suspicion of TB. The assessment of the serological status of people under chemotherapy is worth the analysis, a high IgG level being associated with immunocompetence while the absence of IgG antibodies and/or the presence of IgA antibodies denotes an immunologically misdirected response potentially opening the way to chronic infections.
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PMID:Serological IgG, IgM and IgA diagnosis and prognosis of mycobacterial diseases in routine practice. 936 Sep 40

A 37-year-old man with a history of sarcoidosis, hypertension, asthma, depression and prior intravenous drug use presented with complaints of difficulty in finding his way around the house, headache, and blurred vision in both eyes. The symptoms had been increasing in severity over the prior several months. Physical examination showed normal visual acuity, pupil reactions, and fundi but severe, circumferential constriction of the visual fields bilaterally. The visual fields enlarged appropriately on increasing the distance from the patient to the tangent screen. Neuroimaging revealed bilateral, occipital meningeal involvement and parenchymal lesions consistent with sarcoidosis. Treatment with oral corticosteroids produced a mild subjective improvement in the patient's symptoms and stabilized the visual fields, without improving them. This case represents an unusual presentation of presumed neurosarcoidosis involving the visual pathways at the level of the occipital lobes.
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PMID:Presumed bilateral occipital neurosarcoidosis. A case report. 953 37

Health-related quality of life (QOL) has become an important topic in health care. However, hardly any attention has been paid to QOL in sarcoidosis. Therefore, the aim of this study was to assess the impact of sarcoidosis on QOL. Sixty-four sarcoidosis patients completed the World Health Organization Quality of Life assessment instrument (WHOQOL-100) and the Beck Depression Inventory (BDI). For the WHOQOL-100 a matched group of healthy controls was selected. Patients were divided into two groups: group I (n = 37) consisted of patients with actual symptoms, group II (n = 27) consisted of asymptomatic patients. The WHOQOL-100 revealed a number of areas in which sarcoidosis patients, especially those with current symptoms, experienced problems. A major symptom in both groups of sarcoidosis patients was fatigue. No association between the facet fatigue and the domain psychological health was found. Depressive symptoms (BDI) were associated with psychological function (WHOQOL-100). No association between pulmonary function tests and QOL was found. In conclusion, this study shows that sarcoidosis has a considerable impact on the QOL of patients. The WHOQOL-100 appeared to be a sensitive instrument to measure fatigue--one of the most common symptoms in sarcoidosis--which otherwise is difficult to assess objectively.
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PMID:Evaluation of quality of life in sarcoidosis patients. 1121 13

Sarcoidosis, a chronic, multisystem disease, impacts quality of life and may increase depression risk. No previous study has reported the depression prevalence among U.S. sarcoid patients. This cross-sectional study examined sociodemographic and disease morbidity factors associated with depression. Patients diagnosed for > or = 1 yr and treated at one of six centers were eligible (n = 176); 154 completed a questionnaire of demographics, treatment, access to medical care, and a short-form Center for Epidemiologic Studies- Depression Scale (CES-D). The primary outcome variable was a CES-D score of > or = 9, indicating clinical depression. The prevalence of depression was 60%. Gender, income, access to medical care, dyspnea on exertion, and number of systems involved were associated with depression. Female sex, decreased access to medical care, and increased dyspnea predicted depression (odds ratio [OR] = 3.33, 11.64, and 2.78, respectively) after adjusting for race, income, and steroid therapy. Despite tertiary care access, patients reported medical care limitation. Health care providers must be sensitive to multiple barriers faced by chronic sarcoid patients; acknowledging depression risk and improving access to medical care will promote better overall health among sarcoid patients. Future studies of sarcoidosis will need to address depression diagnosis and treatment.
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PMID:Depression in sarcoidosis. 1117 95

Sarcoidosis is a systemic disease of unknown etiology and highly variable clinical presentation that manifests most frequently in the hilus lymph nodes, skin and eyes. The present case is a 63-year-old woman who was admitted for investigation of progressive apnea. Numerous typical, but also rare, organic symptoms were assignable to a chronic form of sarcoidosis: epileptiform attacks and depression, as also cutaneous changes affecting the scalp, and long wrongly diagnosed granulomatous "tumour" in the left orbit. The correct diagnosis was established on the basis of bronchoscopy and a chest CT that revealed inflammatory fibrotic changes in the lungs, and the histological work-up of tissue biopsies obtained from the various cutaneous lesions.
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PMID:[Dyspnea, alopecia areata, protrusio bulbi. Which systemic disease is responsible?]. 1239 2


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