Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study of 70 ophthalmologically asymptomatic patients with abnormal hemoglobinopathy (AS, SS, S Thal) is presented. A significant number of SS and S Thal group patients had visual acuity of less than 20/20. Retinal vein dilation and tortuosity was observed in 54% of S Thal and 83% of SS patients. Early stages of proliferative retinopathy were encountered in 7% of SS and S Thal patients in the study. The importance of routine ocular examination including meticulous binocular indirect ophthalmoscopy with scleral depression in asymptomatic patients with abnormal hemoglobin is stressed.
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PMID:Retinopathy in ophthalmologically asymptomatic patients with abnormal hemoglobins. 45 42

Patients with diabetes were compared with nondiabetic control subjects, with respect to the prevalence of silent myocardial ischemia, by means of treadmill exercise testing and coronary angiography. Results of treadmill exercise testing showed ischemic ST depression in 41 of the 132 diabetic patients (mean age 61 +/- 4 years) and in 42 of the 140 nondiabetic control subjects (mean age 60 +/- 8 years) (31% vs 30%, p = NS). Coronary angiography was performed in 36 of 41 diabetic patients and 34 of 42 nondiabetic control subjects with positive results of treadmill exercise tests, who gave their consent. Among "treadmill-positive" subjects, diabetic patients had a prevalence of silent myocardial ischemia that was 2.2 times higher than that in nondiabetic control subjects (p less than 0.05). Diabetic patients who received insulin had a 2.6 times higher prevalence of silent myocardial ischemia than those who did not (p less than 0.05). Similarly diabetic patients with retinopathy has a 2.5 times higher prevalence of silent myocardial ischemia than those without it (p less than 0.05).
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PMID:Silent myocardial ischemia in patients with non-insulin-dependent diabetes mellitus as judged by treadmill exercise testing and coronary angiography. 172 50

We describe a new syndrome with autosomal dominant transmission whose most striking feature is vascular retinopathy. The retinopathy is often associated with migraine, Raynaud's phenomenon and mental changes, mainly forgetfulness, aggression and depression. To define this syndrome we collected medical data on 110 family members. General ophthalmological examination and fluorescein angiography were performed in 61 persons. The retinopathy, as diagnosed in 22 persons, is characterized by central and peripheral microangiopathy, areas of capillary non-perfusion, haemorrhages, cotton wool spots and, in a more advanced stage, occlusion of large retinal vessels, which can induce a neovascular response. A vascular occlusive disorder may be the common aetiological factor of the various manifestation of this syndrome.
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PMID:A new autosomal dominant vascular retinopathy syndrome. 182 Dec 4

We examined the physical, sociodemographic, and psychosocial health status of diabetic Mexican Americans aged 45 to 74 years using data from the Hispanic Health and Nutrition Examination Survey. Diabetic Mexican-American women had lower education levels and lower employment rates in comparison with nondiabetics. Glaucoma, retinopathy, and activity limitation were more prevalent in diabetic than in nondiabetic men and women. Diabetic women also had a higher prevalence of hypertension, kidney problems, and cataracts. No significant differences were found in depression levels between diabetic and nondiabetic Mexican Americans of either sex. Among diabetics, duration of diabetes was associated with increased prevalence of stroke and activity limitation. These findings on the health status of diabetic Mexican Americans furthers our understanding of the health service needs of this population.
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PMID:Health status of diabetic Mexican Americans: results from the Hispanic HANES. 184 40

To elucidate the prevalence and features of painless myocardial ischemia among diabetic patients, 44 consecutive patients with angiographically-documented coronary artery disease and positive treadmill tests were examined. They were 26 with diabetes and 18 without it. Painless myocardial ischemia was defined as the absence of chest pain with 1 mm or more ST segment depression during the exercise stress tests. The severity of ischemia was determined by the magnitude of the ST segment depression. Painless myocardial ischemia was observed in 18 of the 26 (69%) diabetics, and in three of the 18 (17%) non-diabetics (p less than 0.005). The frequency of painless ischemia in the diabetics was relatively high regardless of the severity of ischemia, while painless ischemia was less frequent in the non-diabetics with severe ischemia. With a level of 2.5 mm ST depression, 11 of 12 (92%) diabetics were free of pain compared to four of 11 (36%) non-diabetics (p less than 0.01). Absence of chest pain during the exercise tests was not concordant with prior angina in diabetics, as opposed to non-diabetics in whom both clinical and exercise-induced angina developed concordantly. The diabetic patients without chest pain had a higher prevalence of three major diabetic complications such as neuropathy, nephropathy and retinopathy compared to those developing chest pain (p less than 0.025). It was concluded that in diabetics, painless myocardial ischemia is frequently observed during exercise stress tests and its prevalence is relatively high regardless of the severity of ischemia.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Painless myocardial ischemia in diabetic patients with coronary artery disease: evaluations by treadmill exercise tests]. 210 4

The relationship between psychosocial traits and glycaemic control and complications was examined in 130 adults (83 men, 47 women) with insulin-dependent diabetes mellitus. Abnormal depression ratings were observed in more women (19.1%) than men (12.0%), p less than 0.01, whilst obsessive symptoms were recorded more frequently in men (41.0 v 21.3%, p less than 0.01). Abnormal anxiety ratings were present in roughly 8-13% of men and women, although a notably low feeling of insecurity rating was observed more frequently in men (56.5%) than in women (38.3% of cases), p less than 0.05. Psychological scores were related to age, employment status and social class, but not to duration of diabetes or glycaemic control. The anxiety, depression and obsessive ratings correlated with one another (rs range 0.24-0.62, all p less than 0.001). Higher anxiety and depression ratings or overt psychological dysfunction was recorded in patients with neuropathic symptoms and signs, impotence, macrovascular disease or proliferative retinopathy. It is concluded that the presence of diabetic complications and adverse social circumstances are more relevant to psychological status than glycaemic control.
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PMID:A psychometric evaluation of adult patients with type 1 (insulin-dependent) diabetes mellitus: prevalence of psychological dysfunction and relationship to demographic variables, metabolic control and complications. 213 90

We measured cardiac functions by means of mechanocardiogram and echo-cardiogram in 93 patients with diabetes mellitus, excluding those who had apparent cardiac diseases, such as angina pectoris and cardiac failure. We used pre-ejection-period/ejection time (PEP/ET) as the index of the left ventricular systolic function and isovolumic relaxation time (IRT) as that of the left ventricular diastolic function. We compared the diabetic cases without complications to those with complications such as retinopathy, nephropathy, neuropathy and autonomic disorder. Conclusions obtained were as follows; An abnormal IRT was noted in the early stage of diabetic complications. The IRT was not normal among the subjects even when those with cardiac hypertrophy or ST-depression on the ECG were excluded. On the contrary, the PEP/ET did not show any abnormality in the early stage of diabetic complications until they advanced into, eg. renal failure or severe neuropathy. Our findings suggest that the disorder of the left ventricular diastolic function precedes that of the left ventricular systolic function, indicating the association of microangiopathy and autonomic disorder.
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PMID:[Left ventricular function in patient with diabetes mellitus--Evaluated by mechanocardiogram and echocardiogram]. 261 9

Decibel values of threshold sensitivity depression of the retina were evaluated in 69 eyes with NIDDM using the Humphrey automated static perimeter. The eyes were classified into three groups: group I (GI) consisting of 32 eyes with no retinopathy or with stages 1 and 2 of simple diabetic retinopathy, group II (GII) consisting of 21 eyes with stage 3 of simple retinopathy or pre-proliferative retinopathy and group III (GIII) consisting of 16 eyes treated by panretinal photocoagulation using an argon laser. The average age in each group was 60 years and all eyes had a visual acuity of over 0.6. As controls, 16 normal eyes were examined. In comparison with the values of the control, the mean of the sum of decibel threshold sensitivity in the macular retina significantly decreased by 5% in GI, 7.8% in GII, and 24.3% in GIII. It was found that the mean of the sum of decibels in the central retina decreased by 8.2% in GI and 15.5% in GII. The sum of decibels in the mid-peripheral retina showed a decrease of 11.4% in GI and 27.5% in GII. In addition, the decibel values of threshold sensitivity of the lower half of the retina tended to decrease more easily than those of the upper half of the retina in the parafoveal and the macular areas. It was also suggested that decibel values of threshold sensitivity of the retina may decrease shortly after PRP in the paramacular area (located about 10 degrees from the fovea) but not in the foveal area.
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PMID:[Evaluation of diabetic retinopathy by automated static perimetry]. 277 97

The prevalence of diabetes is greatest among older persons, yet few studies have specifically addressed the impact of age on diabetic complications. The present study examines the prevalence of four diabetic complications: retinopathy, peripheral neuropathy, autonomic neuropathy, and hypertension, as well as depression, in older male patients with noninsulin-dependent diabetes. Participants ranged in age from 53 to 80 years. Multiple risk factors, including age, duration of illness, type of treatment, metabolic control, and obesity were evaluated as predictors of these complications using logistic regression. Results suggest a significant increase in the prevalence of retinopathy with aging, independent of the effects of metabolic control, duration of illness, and other risk variables. Age was also related to prevalence of peripheral neuropathy symptoms, hypertension, and impotence. Current metabolic control was significantly associated with retinopathy, peripheral neuropathy, and hypertension prevalence. Time since diagnosis was only independently related to impotence and hypertension. These findings suggest that the increase in many diabetic complications in older persons cannot be wholly accounted for by simple disease status variables, and may result from an interaction of diabetes variables and general age-related changes.
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PMID:Effects of age on complications in adult onset diabetes. 278 81

Little is known about the course of affective illnesses in patients with diabetes or in other physically ill patients. We report a follow-up study of 37 diabetic adults with major depression (according to DSM-III), 28 (76%) of whom were located and reinterviewed 5 yr after the index evaluations. At follow-up, 18 (64%) of the 28 depressed patients had experienced an episode of major depression within the previous 12 mo; 12 of these patients satisfied diagnostic criteria for depression at the time of reevaluation. The 18 patients with recurrent depression had a mean of 4.2 depressive episodes over the 5-yr period. An additional 4 patients met criteria for current dysthymic disorder, bringing the number to 22 (79%) of the total patients ill with affective disorder during the 5-yr follow-up period. In contrast, the likelihood of symptomatic affective disorder was only 10% over the same follow-up period in a comparison group of diabetic subjects without depression at the index evaluation (P less than .001). Occurrence of depressive episodes appeared independent of diabetes complications because both the depressed and comparison groups had similar rates of neuropathy, retinopathy, and nephropathy. These data suggest that the natural course of depression in diabetes is malevolent, possibly more so than depression in the medically well.
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PMID:Depression in adults with diabetes. Results of 5-yr follow-up study. 321 66


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