Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied 20 men (ages 46 to 69, mean 45 years) with chronic obstructive pulmonary disease (FEV1 of 0.55 to 2.1 L), to determine the relative importance of pulmonary impairment vs other occult physical or psychologic factors in the genesis of sexual dysfunction. Seven subjects had ceased sexual activity concomitant with worsening of their pulmonary symptoms; six because of erectile impotence and one due to dyspnea. Frequency of intercourse for the remaining 13 was 16 percent of prelung disease levels, and libido was decreased to 25 percent of premorbid levels. Nocturnal penile tumescence monitoring disclosed that six subjects had organogenic erectile impotence (OEI). None of the subjects showed signs of peripheral vascular disease as assessed by Doppler examination of peripheral pulses (including penile). The mean bulbocavernosus reflex latency (BCRL) for the OEI group (N = 5) was 40.2 msec, while that for the group with full nocturnal erections (N = 10) was 34.5 msec (P less than 0.005). Four subjects had occult diabetes mellitus evident on oral glucose tolerance tests, and one had evidence of an androgen deficit. The correlation coefficient for rank by sexual dysfunction vs pulmonary impairment and age was 0.66 (P less than 0.005) and 0.24 P greater than 0.05), respectively. Subjects with OEI tended to have the worst pulmonary function test results and the highest T-scores on the hypochondriasis, depression, and hysteria scales of the Minnesota Multiphasic Personality Inventory. Data suggest that sexual dysfunction worsens as lung disease worsens and that chronic obstructive pulmonary disease may be associated with male impotence in the absence of other commonly known causes.
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PMID:Sexual dysfunction and erectile impotence in chronic obstructive pulmonary disease. 680 73

Studies have shown that very few women experience significant depression in the weeks following abortion and most have strong feelings of relief and happiness; what mild feelings of guilt, regret, or remorse do exist immediately following abortion tend to diminish quickly. Traditionally attitudes were that abortion could even precipitate psychosis and cause infertility, depression, and sexual dysfunction. The findings of a 1963-65 study of 116 women who underwent abortions indicate that few women had regrets immediately. Studies done after the 1973 Supreme Court decision conclude that even psychiatrically disturbed women who undergo abortion remain stabilized or improved afterwards. Women who do have postabortion problems are usually those who were late aborters, who feel that the decision was not freely made, or that the pregnancy fulfilled certain needs. When working with these women clinicians use a variety of techniques, encouraging the women to express their feelings of loss and anger and supporting the choice that was made, while providing contraceptive and decision making education. The strategy in 3 cases described here involved the woman first saying goodbye to the fetus and her former relationship with it in a gestalt dialogue. The next part of the strategy is establishing positive remembrance of the significant meaning of the fetus to the woman. There are usually 5 sessions at the end of which the woman feels optimistic; the 6th session is a followup 6 months to 1 year later at which most women report no further symptoms.
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PMID:Abortion: a technique for working through grief. 711 93

The incidence of sexual dysfunctions in a group of 51 drug-free depressed patients and in age- and sex-matched controls was studied. Three groups of sexual dysfunction were assessed: alterations of libido, genital symptoms, and menstrual irregularities. The Beck Rating Scale for Depression, the Eysenck Personality Inventory (EPI), and the State-Trait Anxiety Inventory were completed on each participant. Depressed patients obtained significantly higher scores on anxiety, depression, and alterations of libido than controls. Rating scale scores for anxiety and depression were strongly intercorrelated, making the separation of depression-related symptoms from anxiety difficult. In males, the genital symptoms correlated inversely with the L (lie) score of the Eysenck Personality Inventory. There were no interrelationships between the three groups of sexual dysfunction.
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PMID:Sexual dysfunctions in depression. 714 67

Three cases of orgasmic inhibition by clomipramine are reported, one in a male and two in females. All were depressed patients with obsessive-compulsive features. Orgasmic dysfunction manifested shortly after beginning clomipramine therapy despite a return of libido as the depression lifted. Two of these patients switched to desipramine which led to a resolution of sexual dysfunction while maintaining the patients depression free. The third patient manipulated dosage times to diminish the orgastic problem. Strong anticholinergic and/or anti-adrenergic properties of clomipramine are suspected to underlie the development of this problem.
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PMID:Sexual dysfunction and clomipramine. 720 41

Although sexual dysfunction, marital difficulty and depression or other mood disturbance coexist in clinical populations, not infrequently detailed information is lacking about many aspects of relationships between problems in these areas. Methods of measuring sexuality, marital relations and depression are discussed. A pilot study of clinic patients is described and the results obtained using a marital pathology scale, a sexual functioning scale and the Beck Depression Inventory discussed. A small pilot study conducted in general practice indicated the likelihood of an enormous incidence of difficulties with 16.5% of patients admitting a present relationship problem and 15.6% a present sexual one.
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PMID:Some relationships between sex, marriage and mood. 720 14

Current assessment of endocrine function requires multiple sampling regimens. Salivary studies have the advantage of collection by non-invasive techniques, ease of repetition and findings which accurately reflect circulating steroid concentrations. Since hormone concentrations in saliva are low, these investigations require development of highly sensitive, specific immunoassay techniques. Salivary studies may prove useful in assessing the influence of endocrine factors in depression and sexual dysfunction. Clinical and research applications are being rapidly developed.
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PMID:Salivary steroid assays for screening endocrine function. 739 32

Various symptoms are discussed which are of importance in patients undergoing maintenance dialysis for chronic renal failure, such as depression, organic brain syndrome, ambiguity regarding a chronic "incurable" disease, sexual dysfunction and suicidal behaviour. A number of criteria that should be considered at the beginning and termination of regular dialysis treatment are described. Six case reports of selected patients with chronic renal failure and psychiatric problems are discussed. For psychiatric reasons one female patient was not started on maintenance dialysis. One of the patients, a female, did well on maintenance dialysis. One patient died due to medical complications for which treatment was withheld. Two patients decided to quit maintenance dialysis with their doctor's approval. One patient committed suicide unexpectedly.
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PMID:[Psychiatric aspects in the starting and ending of chronic dialysis]. 739 82

Antidepressant drugs are effective for about three in four people with depression. For reasons that are not understood, individual patients who do not respond to one drug often respond to another. Differences in mechanisms of action may thus be important in determining treatment success or failure. In addition to efficacy, drug side effect profile also determines treatment outcome. In general, the fewer or less severe the side effects of a drug, the greater the degree of compliance with treatment. A major consequence of the introduction of selective serotonin-specific antidepressants is greater patient acceptance due to fewer side effects. Still, some patients are unable to tolerate the nervousness, insomnia, or sexual dysfunction associated with these drugs. Drugs that are even more specific in that they act on specific serotonin receptor subtypes, rather than only by blocking serotonin uptake, may provide efficacy and fewer side effects for patients who do not respond to or tolerate less specific agents.
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PMID:The potential benefits of serotonin receptor-specific agents. 752 27

General population surveys suggest that the percentage of US women who drink declined slightly during the 1980s. Comparisons of 1981 and 1991 national surveys using the same drinking measures show that fewer women drank heavily in 1991, and women drinkers drank less frequently and had fewer episodes of heavy drinking, although younger drinkers reported more frequent intoxication. Longitudinal analyses of 5-year changes in drinking behavior indicate that movement both into and out of problem drinking is greatest among women aged 21 to 34. Subgroups of women with elevated rates of heavy drinking and/or adverse drinking consequences include younger women; women lacking social roles or occupying unwanted social statuses; women in nontraditional jobs; cohabiting women; and ethnic minority women experiencing rapid acculturation. Risks of heavy and/or problem drinking are also greater among women with a heavy-drinking husband or partner; depression; sexual dysfunction; or violent victimization in childhood or adulthood. Future research should focus on (1) the causes and consequences of recent declines in women's drinking; (2) antecedents and consequences of specific patterns of multiple substance use in women; (3) social and relational contexts of women's drinking, including occupational influences, drinking behavior of significant others, sexual dysfunction, and relationship violence; (4) longitudinal predictors of both problem drinking onset and "spontaneous" remission of women's alcohol problems; and (5) childhood sexual abuse as a potentially powerful risk factor for later alcohol abuse in women.
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PMID:Drinking and problem drinking in US women. Patterns and recent trends. 762 49

The investigators evaluated the impact of recombinant human erythropoietin (r-HuEPO) therapy on health-related quality of life (HRQL) in predialysis chronic renal disease patients with anemia. Eighty-three patients were entered into a randomized, parallel-group, open-label clinical trial with follow-up evaluations over 48 weeks. Forty-three patients were assigned to r-HuEPO treatment, and 40 patients were assigned to an untreated control group. Hematocrit levels were measured at baseline and monthly. HRQL was assessed at baseline and at weeks 16, 32, and 48. The HRQL assessment included measures of physical function, energy, role function, health distress, cognitive function, social function, home management, sexual dysfunction, depression, and life satisfaction. Significant improvements in hematocrit levels were observed in the r-HuEPO-treated group (P < 0.0001), and no changes were seen in the untreated group. Correction of anemia (hematocrit > or = 36) occurred in 79% of r-HuEPO-treated patients and 0% of control patients. Significant improvements in assessments of energy (P < 0.05), physical function (P < 0.05), home management (P < 0.05), social activity (P < 0.05), and cognitive function (P < 0.05) were found for the r-HuEPO-treated group. No changes were observed in the control group, except for a decrease in physical function (P < 0.05). Between-group differences favoring the r-HuEPO-treated group were found for energy (P < 0.05) and physical functioning (P < 0.05). In patients receiving r-HuEPO, significant improvements were seen in hemotocrit levels, and these increases resulted in improvements in HRQL.
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PMID:Health-related quality of life associated with recombinant human erythropoietin therapy for predialysis chronic renal disease patients. 770 49


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