Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A research project was conducted with the obstetrics and gynecology residents at University Hospitals of Cleveland in February 1976. The purpose was to provide residents with basic knowledge about female sexual problems, to assess the residents' skill and comfort in interviewing patients with sexual problems, to document the effects of supervision on interviewing skills, and to evolve a sexuality curriculum for residents in obstetrics and gynecology. 13 residents at various stages of training participated. The project's 5-1/2 hours were distributed over 2-1/2 weeks. 4 women were taught to respond as if they were patients with the following specific complaints: failure to develop sexual responsiveness, loss of responsiveness due to anger, loss of libido due to depression, and frustration becuase of an impotent husband. The sequence of activities was 1) required reading of a 2-page protocol for assessing a sexual complaint; 2) completion of a preinterview questionnaire which assessed comfort and skill measured on a 5-point scale, immediately followed by a 20-minute videotaped interview with the 1st patient; 3) reading of an article on female sexual dysfunction; 4) attendance at a 2-hour lecture on female sexual dysfunction and interviewing techniques; and 5) conduct of a 2nd, 3rd, and 4th interview over a 2-week period. Each interview was followed by a 45-minute session with the supervisor to view and discuss the videotape. As a group the residents' interviewing abilities failed to improve by the end of the program, as measured by total percentage of programmed content elicited; method of obtaining information, that is, direct or indirect questions; and style ratings. Recommendations are made concerning the educational needs of residents in obstetrics and gynecology.
 ...
PMID:A sexuality curriculum for gynecology residents. 66 Jun 25

Eighteen chronic hemodialysis patients were interviewed by staff trained in sex therapy. Compared with the pre-uremic phase, sexual satisfaction was less in nine subjects, greater in four; frequency of intercourse had declined in ten subjects. Dysfunctions of sexual response were reported by five men and six women. Analysis of physical factors, medication and depression showed no clear association with sexual dysfunction, suggesting the importance of psychosocial factors. A trial of sex therapy in renal patients in proposed.
 ...
PMID:Sexual dysfunction in renal failure: a survey of chronic hemodialysis patients. 70 Sep 25

Systematic studies of relationships among depression, sexual function, and martial discord in hemodialysis patients and their spouses arelacking; existing studies focus upon only one of these three topics, or deal with patient or spouse as individuals rather than as a couple. We studied 17 chronic, medically stable hemodialysis patients and their husbands or wives. Although couples rated their degree of marital discord as low, the investigators rated it as high, based on the number and type of specific problems reported by the couple. The couples' evaluation may not represent denial, as has been commonly assumed. Instead their evaluation may imply that the disease and its treatment overshadow marital problems, even though couples recognize and react to these problems. Couples showed a high prevalence of sexual problems--in terms of overall satisfaction, frequency of intercourse, and specific dysfunctional symptoms (difficulty becoming excited, maintaining excitement, or having orgasm). We found a strong relationship between severity of depression and severity of sexual dysfunction in patients, but not in their mates. No strong relationship existed between a patient's depression score and marital discord, although spouses showed a trend toward correlation between severity of depression and martial discord. Younger couples, especially, seem not to want intercourse when severe martial discord exists. Patients' depression scores were comparable to thoseof psychiatric patients, while spouses' depression scores resembled those of normals. While psychosocial phenomena such as marital discord, sexual dysfunction, and depression are clear, causal chains are not. Despite disadvantages inherent in using questionnaires, short, self-administered, easily scored instruments may elicit problems with sex, marriage, and mood which might otherwise be overlooked by caretaking personnel.
 ...
PMID:Marital discord, sexual problems, and depression. 125 52

Sertraline is a selective inhibitor of central serotonin reuptake. Thus, it enhances serotoninergic transmission--a property which appears to explain its antidepressant activity. Its elimination half-life (approximately 26 hours) makes it suitable for once daily administration. Although clinical experience with sertraline is limited, it appears to possess antidepressant efficacy similar to that of amitriptyline and dothiepin, marginally better than imipramine, and significantly better than placebo. Additionally, sertraline is the only antidepressant licensed in the UK for the prevention of recurrence of depression, and preliminary findings suggest that the drug may also be effective in the treatment of obsessive-compulsive disorder. Sertraline and other serotonin reuptake inhibitors possess tolerability advantages over tricyclic antidepressants. Sertraline has minimal anticholinergic activity, is essentially devoid of cardiovascular effects, has a wide therapeutic index and may be administered to elderly patients or those with underlying cardiovascular disorders. However, as with other serotonin reuptake inhibitors, sertraline has been associated with gastrointestinal disturbances (nausea, diarrhoea/loose stools) and male sexual dysfunction (primarily ejaculatory disturbance), although each of these effects is usually mild and transient, decreasing in frequency with continued treatment. As a drug class, serotonin reuptake inhibitors such as sertraline appear to provide significant advantages compared with the more established antidepressant agents, particularly in terms of tolerability. Although much broader clinical experience is required before sertraline's full therapeutic potential can be realised, if future studies confirm the encouraging initial findings, sertraline will undoubtedly become an important option in the treatment of depression.
 ...
PMID:Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder. 128 Oct 75

Depression and sexual dysfunction have been related to side effects of topical beta-blockers. We performed a preliminary study in order to determine any difference between a non selective beta-blocker (timolol) and a selective beta-blocker (betaxolol) regarding CNS side effects. Eight glaucomatous patients chronically treated with timolol 0.5%/12h, suffering from depression diagnosed through DMS-III-R criteria, were included in the study. During the six-month follow up, depression was quantified through the Beck and Zung-Conde scales every two months. In a double blind cross-over study with control group, the patients under timolol treatment presented higher depression values measured through the Beck and the Zung-Conde scales (p < 0.001 vs control). These results suggest that betaxolol could be less of a depression-inducer than timolol in predisposed patients.
 ...
PMID:Changes in depressive status associated with topical beta-blockers. 142 68

As part of a military universal HIV screening program, 442 men were assessed for the presence of DSM-III-R defined psychiatric disorders and symptoms of anxiety and depression after notification of HIV seroconversion. Of them, 84.4% were in the earliest, asymptomatic stages of disease at the time of interview (96% did not have AIDS). The Structured Clinical Interview for DSM-III-R and Structured Interview Guide for the Hamilton Anxiety and Depression Scales were used. Relevant comparisons were made to Epidemiologic Catchment Area prevalence data. HIV seropositive men were more likely than age-matched men in the community to have current diagnoses of major depression (ages 18-44) and anxiety disorders (ages 25-44). Higher lifetime rates of major depression and alcohol use disorder, and high current prevalence of sexual dysfunction (21.7%) were noted. We conclude that men who become HIV seropositive have high rates of mood and substance use disorders prior to knowledge of seroconversion, and that early in the course of HIV infection men are at risk for developing major depression, anxiety disorders, and disorders of sexual desire.
 ...
PMID:Prevalence of psychiatric disorders in early stages of HIV infection. 143 61

We administered the Derogatis Sexual Functioning Inventory to 25 methadone maintenance patients who had been on a stable dose of methadone for at least 2 months, and obtained ratings of depression and anxiety, levels of sex hormones, and liver function tests. Five subjects with significantly lower Global Sexual Satisfaction Index scores (p < .0001) had more psychological symptoms, higher methadone doses, poorer body image, and less sexual drive and satisfaction, but normal fund of sexual information and lifetime experience. Sexual dysfunction among methadone maintenance patients may be due to coexisting psychiatric problems rather than caused by opiates. Methadone patients presenting with sexual dysfunction should receive psychiatric evaluation.
 ...
PMID:Sexual dysfunction and psychological distress in methadone maintenance. 144 65

The pharmacology and pharmacokinetics, adverse effects, drug interactions, efficacy, and dosage and administration of the new selective serotonin reuptake inhibitors paroxetine, sertraline, and fluvoxamine are reviewed. Paroxetine, sertraline, and fluvoxamine all have large volumes of distribution and are highly bound to plasma proteins. In contrast to fluoxetine, these three drugs possess shorter elimination half-lives of approximately one day and are metabolized to clinically inactive compounds. Nausea was the most commonly reported adverse effect for all three agents. Other reported adverse effects are headache, sedation, dry mouth, insomnia, sexual dysfunction, and constipation. Because of their favorable pharmacokinetic profiles, paroxetine, sertraline, and fluvoxaetine are less likely than fluoxamine to interact with other drugs. Paroxetine has been found to be superior to placebo and equivalent to amitriptyline, imipramine, clomipramine, and doxepin in treatment of depression. Sertraline has been found to be superior to placebo and equivalent to amitriptyline in treatment of depression. Fluvoxamine has been found to be superior to placebo and equivalent to imipramine, clomipramine, desipramine, mianserin, and maprotiline in the treatment of depression. Fluvoxamine and sertraline have been shown to be superior to placebo in the treatment of obsessive-compulsive disorder. Clinical experience has demonstrated all three drugs to be effective in treatment of depression. They may be especially useful in elderly patients, in those who cannot tolerate alternative treatments, and in those who do not respond to adequate trials of other antidepressant therapies.
 ...
PMID:Paroxetine, sertraline, and fluvoxamine: new selective serotonin reuptake inhibitors. 146 19

At the Oxford Haemophilia Centre at Churchill Hospital in Oxford, England, psychiatrists compared data on 37 HIV seropositive hemophiliacs (31 asymptomatics and 6 symptomatics) with data on 36 HIV seronegative hemophiliacs to determine the prevalence of psychosocial conditions in HIV seropositive men and factors related to those conditions. HIV seropositive men had much higher Present State Examination scores than did the HIV seronegative men (5.9 vs. 2.2; p=.005). This was true for both symptomatic and asymptomatic HIV seropositive men (7.3 and 5.7, respectively). Nevertheless, these levels of psychological disturbance were basically the same as the general outpatient medical population as was also the case with depression scores (POMS). Still symptomatic HIV seropositive men were more likely to be depressed than HIV seronegative men (6.4 vs. 3.6; p=.02). The most important finding was that both symptomatic and asymptomatic HIV seropositive men felt significantly higher levels of hopelessness than did the HIV seronegative men (6.5 vs. 2.6; p=.0004, asymptomatic-5.8 and symptomatic=9.7). Hopelessness indicated an increased risk of suicide which is independent of depression. Past psychiatric history (r=0.38), hopelessness (r=0.55), and poor social adjustment (r=0.55) accounted for 49.8% of the variance (p.001). HIV seropositive men exhibited more psychosexual dysfunction especially premature and delayed ejaculation (30% vs. 4% and 20% vs. 0, respectively; p.05) than HIV seronegative men. Among the men who had a sexual relationship, HIV seropositive men tended to always use condoms during intercourse (79% of asymptomatics and 100% of symptomatics vs. 25% of HIV seronegatives; p=.0004). Even though they used condoms, HIV seropositive men were more likely to worry about infecting their partners than HIV seronegative men (p=.02).
 ...
PMID:The psychosocial impact of HIV infection in men with haemophilia: controlled investigation and factors associated with psychiatric morbidity. 161 81

Somatic symptoms are one of the leading reasons for medical outpatient clinic visits, with the most common symptoms having a prevalence of 10% or more. However, the usual diagnostic workups are often unproductive, with less than 1 in 5 symptoms having an organic explanation after the initial physical examination and laboratory testing. Therapy appears more effective for some symptoms than for others. Of patients with unspecified pain or gastrointestinal complaints, greater than 70% state that some type of treatment has been helpful, whereas less than 50% of individuals with fatigue, dizziness, numbness, insomnia, sexual dysfunction, anxiety, or depression report any relief. Future educational efforts and research need to focus on that majority of symptoms that are either psychiatric or unexplained, in order to improve our current evaluation and management strategies.
 ...
PMID:Symptoms in medical patients: an untended field. 173 31


1 2 3 4 5 6 7 8 9 10 Next >>