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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The significance of the direction of the ST-segment shifts on the 12-lead electrocardiogram was evaluated in 82 consecutive patients with unstable angina. Eighteen patients with ST-segment elevation (group I) were compared with 64 patients with ST-segment depression (group II). There was no difference between group I and group II with regard to age, sex, or history of previous myocardial infarction. There also was no difference in the angiographic extent, location or severity of the coronary artery disease, collaterals, or resting hemodynamics. A larger proportion of patients in group I presented with recent onset angina. Life-threatening arrhythmias were more frequent in group I but were uncommon in both groups. A normal resting electrocardiogram was associated with normal ventricular function in both group I and group II but was associated with single vessel disease only in group I. An abnormal resting electrocardiogram was associated with multiple coronary vessel disease and abnormal ventricular function in both groups. Single vessel disease was encountered twice as frequently in group I but this difference was not statistically significant. Left main coronary artery disease was found only in group II.
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PMID:Transient ST-segment in unstable angina. Clinical and hemodynamic significance. 113 90

The Minnesota Multiphasic Personality Inventory was completed by 101 patients 16 to 18 months after a proved myocardial infarction. The data suggested a bimodal distribution of patients. One class of patients had a relatively "normal" personality score apart from a tendency to hypomania. The second class had severe depression, with associated hysteria, hypochondriasis and psychasthenia. The severely depressed patients were older, with a greater tendency to hypertension and angina, and a tendency to smaller gains in aerobic power despite an equal intensity of endurance training. The distinction between "normal" and "depressed" postinfarction patients seems of some clinical importance, for the two classes of patients require opposite supportive techniques--restraint and encouragement, respectively.
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PMID:Depression after myocardial infarction. 114 70

Eleven elderly patients with idiopathic pericarditis are reported. All but one were older than 60 yr. Evidence of ischemic cardiovascular disease was present in 8 patients. The initial diagnosis was heart failure with pulmonary complications in 4 cases and myocardial infarction in 3. Respiratory infection preceded the onset of pericarditis in 5 cases. Presenting symptoms were typical precordial pain, fever and dyspnea. Pericardial friction was found in 7 cases and transient rhythm disturbances in 5. Four patients had ST elevation and 3 had ST depression in their electrocardiograms. Other findings included an increased sedimentation rate, leukocytosis, elevated venous pressure and normal SGOT levels. Antibiotics were of no avail but prednisone had a dramatic effect. Two patients had a relapsing course lasting 2 yr or more. One patient, who died at the age of 75 from bleeding ulcer, had patent coronary arteries and mild perimyocardial fibrosis. The diagnosis of idiopathic pericarditis in the aged is difficult because the disease simulates ischemic heart disease in patients who frequently have evidence of arteriosclerotic cardiovascular involvment.
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PMID:Acute idiopathic pericarditis in the aged. 114 70

The effects of the positive-inotropic drug Canrenoat-Kalium (CRK) on the extent and severity of myocardial ischemic injury and on hemodynamic parameters were studied in 17 dogs following coronary occlusion. Acute myocardial infarction causes depression of left-ventricular function. There eas a significant decrease in dp/dtmax, stroke volume and cardiac output; average values for mean arterial pressure were reduced, but not significantly. There was a significant increase in left-ventricular enddiastolic pressure. Heart rate was unchanged. In the healing phase of myocardial infarction a significant elevation of left-ventricular enddiastolic pressure and a significant decrease of arterial pressure persisted, but the other parameters had returned toward normal. Intravenous administration of CRK (20 mg/kg) one hour after coronary occlusion causes a significant increase in left-ventricular dp/dtmax, cardiac output and stroke volume, but no significant change in arterial pressure, heart rate and left-ventricular enddiastolic pressure. Four days after myocardial infarction administration of CRK causes also a significant incrrease in left-ventricular dp/dtmax and -n 4 out of 5 animals an increase in stroke volume. Heart rate, arterial pressure and left-ventricular enddiastolic pressure are unchanged. There is a continuous deterioration of all hemodynamic parameters in the control group 1 hour and 96 hours after experimental myocardial infarction. This spontaneous deterioration has to be taken into consideration estimating the effect of CRK in experimental conditions. 120 epicardial electrocardiographic recordings were used to assess the extent and severity of myocardial ischemic injury. The average ST-segment elevation and the number of sites with abnormal ST-segments were significantly reduced 20 min after CRK administration. The study suggests a beneficial therapeutic role for CRK treatment of left-ventricular failure in the acute and healing phase after myocardial infarction.
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PMID:[Influence of canrenoate potassium (aldactone pro injections) on hemodynamics and myocardial ischemia in experimental myocardial infarct]. 116 92

Precordial ST-segment mapping Was applied serially in the coronary care unit for the study of 46 patients with myocardial infarction (MI), using a 49-lead system. Data from the maps were compared with clinical status of patients, conventional ECGs obtained simultaneously, and serum enzyme levels. Stability of the maps over a one hour period was noted in the early phase of admission. However, a drop of 32% of the sum of ST-segment elevations (+sigma ST) was detected in eight patients with uncomplicated anterior MI over the first 24 hours after admission. Extension of infarction was associated with abrupt rise of + sigma ST, and was diagnosed in two cases from maps in the presence of unchanged standard ECGs. The course of ST elevations was followed more accurately by the map than the standard ECG in eight patients. Pericarditis invalidated the technique completely, due to persistent + sigma ST. The standard ECG was superior to the map in following patients with inferior MI. A case of true posterior MI was more accurately delineated by maps of the posterior thorax than by the standard ECG. Intraventricular conduction defects and pacemaking interfered with maps. Early repolarization produced stable maps; however, mapping showed no advantages over the standard ECG. Preinfarction angina can probably be followed by serial mapping of ST-segment depression.
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PMID:Precordial ST-segment mapping 1. Clinical studies in the coronary care unit. 117 61

Sequential injections of different contrast material in the canine coronary artery were performed while ventricular pressure and EKG were recorded. Larger volumes of contrast material caused more fibrillation and more drop in pressure. Preliminary myocardial infarction increased pressure effects. Diatrizoate methylglucamine (Renografin-76) caused more fibrillation and lowering of ventricular pressure than iothalamate or metrizoate Coronar. Calcium lessened the ventricular pressure depression from iothalamate.
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PMID:Toxicity studies of coronary arteriographic media in dogs. 118 22

Previous studies have demonstrated that catecholamines produce massiive disseminated cardiac necrosis closely resembling experimental myocardial infarction. Since catecholamine-induced lipolysis increases myocardial oxygen demand and increased levels of FFA are associated with a depression of myocardial function during myocardial hypoxia, the effect of inhibition of lipolysis on myocardial necrosis induced by isoproterenol was studied. Measurements of creatine phosphokinase (CPK) activity in extracts of whole heart homogenates provide a sensitive and relatively specific index of cellular necrosis. Accordingly, CPK activity was measured in rat hearts 48 hours after the animals had received either isoproterenol, given s.c., 3 times at hourly intervals, or isoproterenol after prior administration of nicotinic acid. Control animals were given saline. With increasing doses of isoproterenol, CPK activity in whole heart homogenates was depressed from 21.7 +/- 0.40 in untreated animals (N = 36) to 14.9 +/- 0.46 in animals given the highest dose of isoproterenol (N = 47). In animals in which isoproterenol-induced lipolysis was inhibited by nicotinic acid, CPK was less depressed (16.3 +/- 0.36, N = 47) than with isoproterenol alone (p less 0.02). Nicotinic acid given alone did not interfere with CPK activity. This study suggests that part of the necrosis induced by isoproterenol is due to increased release and oxidation of FFA in the rat heart.
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PMID:Role of free fatty acids in catecholamine-induced cardiac necrosis. 119 80

It is reported on the results of the treatment with artificial ventilation in 20 patients with complicated myocardial infarction. As indicating sign a decreased arterial PO2 (lower than 70 Torr at an respiration of 50% O2 in the respiration air) was considered. Further references to clinical indications were depression of the breathing centre, severe pulmonary oedema, shock and life-threatening therapy-resistent disturbances of the rhythm. The long-term successes of the treatment with controlled respiration showed a clear dependence on the severity of the cardiac lesion and the general condition of the patient. In 10 cases only a transient improvement could be achieved. Three patients survived.
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PMID:[The clinical significance of controlled artificial respiration in patients with acute myocardial infarct]. 119 86

Intravenous infusion of 10 to 30 gamma/min. of Isuprel for 3 to 7 minutes is accurate in diagnosing coronary disease in at least 80% of cases in our series of 100 patients with segmental coronary artery stenoses of 50% or more, demonstrated by coronary angiography. By comparing these 100 patients with a control group of 30 healthy subjects we can state that the late "ST" segment changes (persisting or appearing 3 minutes after stopping the infusion) are typical of coronary insufficiency. In patients without previous infarction, coronary insufficiency is expressed by a horizontal "ST" depression of 1 mm or more. In patients with previous infarction we observed either an "ST" depression or an "ST" elevation. The "ST" elevation, never observed in the control group, seems to have a different significance depending on whether or not a previous myocardial infarction has occurred. If there was no previous necrosis, severe coronary artery disease seems to be suggested and is a bad prognostic sign. This is not so if the patient has previously presented a myocardial infarction.
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PMID:[The isoproterenol test in the electrocardiographic diagnosis of coronary insufficiency. Experience in 100 cases of ischemic cardiopathy]. 120 42

Ergometric and coronary angiographic findings were compared in 145 patients with proximal lesions of at least 50% of major coronary arteries. 75% of the patients had had a previous myocardial infarction. The following ergometric parameters occur most frequently in 3-vessel disease. (1) coronary insufficiency persisting after myocardial infarction, (2) ST-segment depression of at least 0.2 mV, (3) maximum exercise tolerance limited to less than 75 Watts. However, these parameters cannot predict 3-vessel disease with absolute certainty, nor can they exclude a single vessel disease. 3-vessel disease is not likely, if there is a maximum heart rate of 150 beats per minute or more. There were only slight differences between patients with 1-vessel disease and patients with 2-vessel disease. Patients who were limited at the 50 Watts level were found to have significant LAD disease, either alone or in combination with other vessels, with the exception of one patient.
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PMID:[Ergometric findings depending on the severity and localization of coronary artery disease (author's transl)]. 120 30


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