Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pre- and postoperative systolic time intervals, hemodynamics and serum catecholamines were studied in 30 patients with successful myocardial revascularization surgery or left ventricular aneurysmectomy and the influence of the surgery on the left ventricular function was evaluated. 1. Significant depression of left ventricular performance was recognized in the group of patients with left ventricular aneurysm as compared to the patients with angina pectoris with or without previous myocardial infarction before the operation. 2. At 2 hours after the operation, signigicant decrease of ET/PEP, cardiac index and stroke work index and marked elevation of systemic vascular resistance were seen in the group of patients with aortocoronary bypass surgery who had previous myocardial infarction and with left ventricular aneurysmectomy as compared to the group of patients without previous myocardial infarction. 3. At 2 hours after the operation, ET/PEP seemed to reflect the left ventricular stroke work and the depression of the left ventricular function was mainly affected by the elevation of systemic vascular resistance due to the hypersecrection of serum catecholamines. 4. Reduction of systemic vascular resistance by vasodilator brought an improvement of EG/PEP, cardiac index and stroke work index.
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PMID:Influence of surgery for ischemic heart disease on early postoperative left ventricular function. 51 68

The cardiovascular response to treadmill exercise testing and to isometric handgrip was compared in 20 selected patients three to five weeks after acute myocardial infarction. The heart rate and the heart rate-systolic blood pressure product were significantly higher during treadmill exercise than during two minutes of isometric handgrip sustained at 25% of maximum voluntary contraction. No significant difference in systolic blood pressure was noted between the two types of exercise while diastolic blood pressure was higher during isometric exercise. Asymptomatic ST-segment depression was noted in two patients during the the treadmill test and was absent during handgrip. Angina pectoris was not noted during either type of exercise. Ventricular ectopic activity was slightly more frequent during treadmill exercise. Isometric handgrip at 25% of maximum voluntary contraction may be performed safely soon after myocardial infarction and provides useful guidelines for performing many customary physical activities requiring upper extremity isometric exertion during early convalescence.
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PMID:A comparison of static and dynamic exercise soon after myocardial infarction. 52 73

The hyperacute phase of true posterior myocardial infarction is described in detail. This electrocardiographic manifestation, hitherto unnamed as such, presents with slope-depression of the S-T segments with relatively wide and deep T-waves in the right precordial Leads V1 to V4. The condition then progresses to the well-recognized fully evoked phase of acute true posterior wall myocardial infarction.
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PMID:The hyperacute phase of true posterior infarction. 58 24

Although the shock state due to acute myocardial infarction may be reversed by IABP in 80 per cent of patients, 55 to 65 per cent remain balloon-dependent. Therefore some attempt to correct the underlying anatomic abnormalities (reversible ischaemic areas and/or mechanical defects) appears necessary if these patients are to survive. With IABP catheterization studies performed in these critically-ill patients are well tolerated. Myocardial depression after cardiopulmonary by-pass is often related to subendocardial ischaemia. The combination of IABP and surgery has resulted in survival of approximately 50 per cent of patients in cardiogenic shock secondary either to a mechanical defect complicating myocardial infarction or to open-heart surgery.
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PMID:Mechanical circulatory assistance by intra-aortic balloon pumping for the treatment of cardiogenic shock. 62 12

Transient organic causes of impotence include alcohol consumption, drug use or inflammatory genital disease. Many diagnoses of organic impotence, with diabetes, for example, have been premature and have resulted in iatrogenic, psychogenic impotence. After a stroke, heart attack or major surgery, depression may cause impotence. Anxiety and sexual ignorance are major etiologic factors. Thus, sex education and uncomplicated sex therapy can achieve a high percentage of cure. Penile plethysmography during sleep provides useful information. Penile prostheses are helpful for appropriately motivated couples when there is permanent impotence.
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PMID:Impotence--some causes and cures. 62 40

A follow-up study of 1,402 patients with a positive maximal treadmill stress test was made to evaluate the significance of angina during the test. Life tables were constructed and evaluated for significance of age, sex and work load at onset of angina. Coronary events (myocardial infarction, progression of angina and coronary death) were twice as frequent in subjects with angina and S-T segment depression as in those without angina. The increased incidence in 4 years held for all coronary events and was still doubled at 7 years for progression of angina and coronary death. The incidence of coronary events was more than twice as great when the angina was induced by a light work load (4 metabolic equivalents = METS) as when it was induced by a heavy work load (8 to 9 METS). Men aged 41 to 50 years having angina during exercise testing had a 3-fold greater incidence of coronary events and a 4-fold greater incidence of myocardial infarction compared with their counterparts who had S-T segment depression alone. In this study, angina during exercise testing identified 85% of true positive tests for coronary artery disease, whereas S-T depression alone identified only 64% of such tests. Thus, angina during exercise testing increases the sensitivity of the test and identifies cohorts of subjects at high risk for subsequent coronary events.
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PMID:Significance of chest pain during treadmill exercise: correlation with coronary events. 62 16

Clinical and experimental observations in which bundle branch block patterns (BBBP) in ECG leads were normalized by distal His bundle (H) pacing are reported. The clinical material includes four patients with acute right BBBP secondary to anterior wall myocardial infarction and three patients with chronic left BBBP. Six of the seven patients had a prolonged H-V interval (60-85 msec) including three who showed evidence of an intra-H conduction delay (IHCD) with split H (H and H'). Distal H pacing from a right-sided electrode catheter normalized the BBBP with a stimulus-to-QRS (PI-V) interval 20-35 msec shorter than the H-V interval and almost identical to the H'-V interval in the three patients with documented IHCD. In 18 dogs ligation of the anterior septal artery resulted in IHCF with split H associated with right or left BBBP. Distal H pacing from catheter and/or plunge wire electrodes normalized the BBBP in 12 experiments (67%) with a PI-V interval identical to the H'-V interval. H pacing was selective and direct stimulation of myocardium was excluded by monitoring the high ventricular septal electrogram. The clinical and experimental observations are discussed as evidence that functional longitudinal dissociation is probably only operative in the pathologic H due to selectively greater depression of conduction in the transverse interconnections.
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PMID:Normalization of bundle branch block patterns by distal His bundle pacing. Clinical and experimental evidence of longitudinal dissociation in the pathologic his bundle. 62 57

During the acute phase of myocardial infarction, patients may experience anxiety, depression, denial and decompensation. Their ability to master the painful aspects associated with the stress of this severe illness and to convert defenses to beneficial coping directions depends on their character traits and effective psychiatric intervention. Sequelae to myocardial infarction include invalidism and prolonged disruption of the patient's family life and development.
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PMID:Psychologic stress in myocardial infarction. 62 95

Myocardial perfusion imaging with thallium-201 and electrocardiography with the subject at rest and undergoing submaximal treadmill exercise were performed in 19 men and 3 women. Selective coronary arteriography and left ventriculography showed that 7 had normal coronary arteries and 15 had coronary artery disease.The 11 persons with electrocardiographic evidence of an old myocardial infarct (q waves) had a perfusion defect at rest in the area of the infarct and a segmental abnormality of wall motion apparent on the left ventriculogram corresponding to the perfusion defect.MYOCARDIAL PERFUSION IMAGING AND ELECTROCARDIOGRAPHY WERE EQUALLY SENSITIVE IN DETECTING CORONARY ARTERY DISEASE IN EXERCISING INDIVIDUALS: perfusion defects were noted in 7 of the 15 persons with coronary artery disease, and diagnostic ST-segment depression was present in 8 of the 15. Combination of the results of the two tests with exercise permitted the identification of 11 of the 15 persons and improved the sensitivity. Combination of the results of rest and exercise imaging and electrocardiography permitted the identification of 94% of the patients with coronary artery disease.Myocardial perfusion imaging with (201)TI in the subject at rest is a sensitive indicator of previous myocardial infarction. Imaging after the subject has exercised is a useful adjunct to conventional exercise electrocardiography, especially in those whose exercise electrocardiogram is non-interpretable.
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PMID:Myocardial perfusion imaging with thallium-201: correlation with coronary arteriography and electrocardiography. 63 Apr 87

Although many patients with coronary artery disease (CAD) have a positive exercise test without pain, the frequency and significance of this "silent" ischemia is unclear. Therefore, we studied 122 consecutive clinically stable patients with angiographically defined CAD (greater than 75 per cent luminal stenosis) and a positive exercise test. Seventy-eight patients had pain or anginal equivalent during or after a positive exercise test; 44 did not, including 32 (26 per cent) with no symptoms at all. Patients were evaluated as to age, sex, prior myocardial infarction, congestive failure, hypertension, diabetes mellitus, and digoxin or propranolol therapy--in addition to anginal symptoms before, during, or after the exercise itself. Extent of CAD, presence of collaterals, and left ventricular ejection fraction were also determined. All exercise tests were evaluated for evidence of ST-T abnormalities or prior infarction on the control ECG as well as peak heart rate during exercise and post-exercise degree of ST segment depression. There were no significant differences between patients with and without exercise-induced pain in regard to any of the clinical and angiographic features noted above, demonstrating that "silent" myocardial ischemia during or after exercise testing is not uncommon and is not readily attributable to any obvious clinical or catheterization findings. Further studies are necessary to determine if patients with evidence of "silent" myocardial ischemia are especially prone to sudden death.
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PMID:"Silent" myocardial ischemia during and after exercise testing in patients with coronary artery disease. 63 80


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