Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Dexamethasone Suppression Test (DST) was performed for three groups of institutionalized patients with mental retardation: (a) patients with symptoms of depression, (b) nondepressed patients with other problematic behavior (aggressiveness, self-injurious behavior, or withdrawal), and (c) control subjects with no behavioral or psychiatric symptoms. Results showed that depressed patients more frequently (though not significantly) had positive DSTs and significantly higher cortisol levels compared with the other two groups. Patients with other problematic behavior did not differ from control subjects. The DST may be particularly valuable in diagnosing depression in individuals with severe mental retardation, who are often nonverbal and unable to express depressive symptoms.
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PMID:The dexamethasone suppression test as an indication of depression in patients with mental retardation. 790 20

A 14-year-old boy with mental retardation presented with severe thrombocytopenia, macrocytic anaemia and allergic dermatitis. He had been treated with valproate for seizures since the age of 2 years. Clinical examination showed severe purpura, mucous bleeding and extensive dermatitis. Tests to detect serum direct antiplatelet antibodies were positive and bone marrow examination revealed myelodysplastic abnormalities. Valproate was discontinued and both dermatitis and general condition of the child improved with normalization of the full blood count. This report suggests that valproate may produce both peripheral immune thrombocytopenia and severe bone marrow depression several years after the initiation of the therapy.
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PMID:Haematological disturbances during long-term valproate therapy. 803 31

Investigated the association between various depression assessment methods in 38 adults with mild or moderate mental retardation, half of whom had relatively high and the other half had relatively low depression screening scores. Measures included a standard psychiatric interview (Diagnostic Interview for Children and Adolescents), an informant rating scale (Reiss Screen for Maladaptive Behavior), and a self-report measure (Self-Report Depression Questionnaire). Association between measures was generally low, yielding discordant classification results. Potential reasons for these discrepancies were offered, and implications for clinical and research assessment of mood disorders in mental retardation were discussed.
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PMID:A comparison of assessment methods for depression in mental retardation. 805 Sep 84

The applicability of the Children's Depression Inventory (CDI) in the informant-rating version to mentally retarded adults (> 19 years of age) of all degrees of severity is researched here for the first time. The sample (N = 798) consisted of residents in community-based group homes (56.9%) and residents of a variety of institutions (43.1%). On average, 23 of the 24 CDI items were to be assessed. Internal consistency, interrater reliability, and the item-total score correlations were adequate. The three factors derived from factor analysis were open to clear interpretation. The CDI score proved to be independent of age, sex, and degree of mental retardation. Persons with behavior problems, psychotropic drug treatment, non-Down syndrome status, as well as the residents of a psychiatric clinic, all returned a higher CDI score. Among those having a CDI score > or = 17 (n = 54), there were 57% with DSM-III-R depressive disorders. These results suggest that the CDI in an informant-rating version is suitable as a diagnostic and screening instrument for mentally retarded adults.
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PMID:Assessment of depression in mentally retarded adults: reliability and validity of the Children's Depression Inventory (CDI). 821 Jun 7

The purpose of this paper is to provide psychiatrists with practical advice on how to detect malingered mental illness. Various types of malingering are defined and the five major purposes of malingering are specified. The research literature on malingering is reviewed. Clinicians must be thoroughly grounded in the phenomenology of true mental disease to detect malingering. Detailed information about hallucinations is reviewed so that faked hallucinations that do not follow typical patterns can be more easily identified. Strategies for approaching persons suspected of malingering are suggested. Features of malingered mutism, mania, depression and mental retardation are described. The differential diagnosis of malingering, post-traumatic stress disorder, conversion disorder, and post-concussion syndromes after trauma is discussed. Clues to malingered psychoses and post-traumatic stress disorders are delineated. Finally, specific indicators of malingered insanity defenses are identified.
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PMID:Defrocking the fraud: the detection of malingering. 827 Mar 91

A survey of affective symptoms in two groups of institutionalized adults with mental retardation was conducted. The groups were comprised of subjects with prior diagnoses of affective disorders or other psychiatric disorders. Informants reported retrospectively on the presence or absence of DSM-III-R criteria for major depression and mania. Thirteen percent of the affective disorders group did not meet these criteria for depression or mania, whereas 20% of the other psychiatric disorders group did. Aggression was a frequent concomitant of psychopathology in both groups. These findings support previous reports that affective disorders may be underdiagnosed in this population. However, unlike prior investigations, most of the subjects (74%) in the present survey had severe to profound mental retardation.
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PMID:Affective symptoms of institutionalized adults with mental retardation. 829 17

The performance of 25 mentally retarded and 25 normal IQ adolescents was investigated on self-report and informant versions of three childhood depression measures. These measures included the Children's Depression Inventory, the Bellevue Index of Depression, and the Reynolds Child Depression Scale. Adolescents with mild to severe levels of mental retardation were studied. Strong correlations between total scores of measures were found. Analyses of variance comparing mentally retarded and intellectually average adolescents differed significantly only on the Bellevue Index of Depression. Finally, the relationship between self-report and informant versions of these measures were correlated, with mixed results. Implications for the use of these scales in assessing depression of mentally retarded adolescents are discussed.
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PMID:Assessment of depression in mentally retarded adolescents. 831 81

The relationship between aggression and depression was evaluated for 528 adults, adolescents and children, who were rated on either the adult or child versions of the Reiss instruments for dual diagnosis (Reiss 1988; Reiss & Valenti-Hein 1990). Criterion levels of depression were evident in about four times as many aggressive as nonaggressive subjects. Anger was significantly associated with both aggression and depression. Although anger may play a mediational role in the correlation between aggression and depression, in this study there was a significant correlation even after the effects of anger were held constant. The findings provide an initial step toward improving diagnostic specificity when evaluating aggressive behaviour in people with mental retardation.
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PMID:Joint occurrence of depression and aggression in children and adults with mental retardation. 833 20

Self-report measures of depression, general psychopathology, and social skills were administered to adolescents ranging from moderate mental retardation to above normal intelligence. Adolescents with mental retardation reported more depression and general psychopathology symptoms. Variance and regression analyses demonstrated distinctions on the basis of mental retardation status for individual measures. Additional analyses identified differences between individuals with above normal intelligence and individuals with mild mental retardation on the basis of depression specifically. Adaptive behavior functioned as a moderator variable, mediating the relationship between depression and intellectual functioning.
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PMID:Adolescent depression: relationships of self-report to intellectual and adaptive functioning. 853 15

A 62-yr-old woman with a history of mental retardation, paranoid psychosis and agitated depression presented with deterioration in her baseline mental status and fever. No obvious source of fever was found on clinical exam or on initial laboratory studies. An 111In-white blood cell (111In-WBC) study was performed 1 wk after hospital admission, which revealed increased uptake in the anterior neck and oral cavity. Subsequent laryngoscopy revealed a red, swollen epiglottis compatible with epiglottitis. While not advocating 111In-WBC scintigraphy as part of the workup of epiglottitis, this case is presented to emphasize the possible milder presentation of epiglottitis in adults compared to children.
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PMID:Clinically unsuspected epiglottitis detected by indium-111-white blood cell scintigraphy. 854 6


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