Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The respiratory control center receives afferent stimuli from mechanical and neuromechanical sources. Information from both these sources, combined with voluntary and involuntary CNS control, effects stimulation of the respiratory muscles. In the infant, insufficiency of one or more of these elements of the respiratory control center is associated with considerable morbidity and mortality. Pharmacologic manipulation may provide a means of intervention. The xanthine derivative theophylline has been successfully used in the treatment of bronchopulmonary dysplasia and apnea in the infant. Naloxone, an endorphin antagonist, is widely used for the reversal of narcotic-induced respiratory depression but has not been shown to be clinically effective for either severely or moderately asphyxiated infants. Although doxapram has not been extensively studied and lacks an oral preparation, it is a potentially viable therapy in the treatment of refractory apnea and congenital hypoventilation syndromes. Almitrine's success in adults with chronic obstructive pulmonary disease has not been duplicated in infants with similar respiratory impairments. Progesterone and prostaglandin, although proved to influence respiratory activity, should be regarded as very experimental therapeutic modalities.
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PMID:Pharmacologic manipulation of the respiratory control center in the infant. 219 44

The effects of pulmonary rehabilitation (PR), target-flow inspiratory muscle training (IMT) and a combination of both treatments (PR + IMT) on psychological parameters and the physical performance were studied in a group of sixty chronic obstructive pulmonary disease (COPD) patients with a ventilatory limitation during exercise (mean age +/- 59, mean FEV1 +/- 50% of predicted). After the ten week training period scores of anxiety and depression were decreased in the PR and the PR + IMT group, but not in the IMT group. In the PR group these scores were still decreased after a one year follow up period. Maximal workload and the activities in daily life (ADL) scores were improved significantly after the training period in the PR and the PR + IMT group. Most of these improvements had disappeared after one year. The 12 min walking distance was increased in all patient groups after the training period and was still increased after the follow up period. The exercise capacity was correlated significantly to lung function parameters. The psychological well-being, however, was not correlated with lung function parameters, but was closely related to ADL scores. The improvement of the psychological parameters was not correlated to the improvement of the exercise capacity after the training period or after one year. The results indicate that the psychological well-being and the physical condition are improved by different mechanisms during a pulmonary rehabilitation programme.
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PMID:Psychological changes during pulmonary rehabilitation and target-flow inspiratory muscle training in COPD patients with a ventilatory limitation during exercise. 226 55

Mind and body remain stubbornly one. The distinction between primary and secondary disorders respects this unity. The distinction between "reactive" and "induced" carry causal implications and suggest the former is psychogenic and the latter organic--both of which are probably premature conclusions. The diagnostician, free of the demands on the pathologist, can pursue the correct nosology committed to demonstrating, not the pathophysiology, but the presence of adequate diagnostic criteria. Whenever a secondary disorder meets full criteria it may warrant the same treatment accorded to the primary disorder. Whether the disease is major or minor may also be of clinical significance. Only further application of psychiatric nosology to medically ill patients can resolve these issues. Karajgi et al recently found that the lifetime prevalence of panic disorder in a sample of patients with chronic obstructive pulmonary disease was 8%. The only respectable offspring of neurotic depression in DSM-III-R is dysthymia. As with neurotic depression, dysthymia is not a condition thought appropriate for or responsive to antidepressant drugs. Clinicians dealing with depression in the medically ill think of depression itself as "serious," that is, major.
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PMID:Depression and anxiety secondary to medical illness. 228 Oct 8

The level of dyspnea reported by the patient with chronic obstructive pulmonary disease is related to both the physiologic and psychologic state of the person at the time. The purpose of this pilot study was to explore, from a psychophysiologic perspective, the differences in anxiety, depression, and somatization during times of high and low levels of dyspnea. Six male subjects with chronic obstructive pulmonary disease, with a mean age of 64 years and a mean forced expiratory volume in 1 second that was 44% of predicted, completed the study. They were assessed for clinical signs and their level of dyspnea indicated on a vertical visual analogue scale, after which they completed the Spielberger State Anxiety Inventory and the Brief Symptom Inventory. Arterial blood was then drawn for blood gas analysis and determination of cortisol level. All measures were repeated twice, once when the subject reported a high level of dyspnea and once when he reported a low level. Analysis of the data by use of t tests for paired groups indicated that during times of high dyspnea levels subjects had greater anxiety, accessory muscle use, cortisol level, and PCO2 level. Subjects receiving oral prednisone had high depression levels that increased during times of severe dyspnea. Somatization, PO2, respiratory rate, depth of respiration, and other clinical signs did not change with dyspnea level. These results indicate that dyspnea is accompanied by both psychologic and physiologic changes that can be targeted to assist in alleviating this distressing symptom.
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PMID:Psychophysiologic aspects of dyspnea in chronic obstructive pulmonary disease: a pilot study. 234 Dec 63

Chronic obstructive airways disease (COAD) is a major, though neglected, medical and social problem in the United Kingdom today. Dyspnoea is one of the most distressing and disabling symptoms of COAD, which is itself the largest single cause of absence from work in the United Kingdom. 92 patients suffering from COAD were interviewed in order to assess impairment, disability and handicap. Measures included spirometric tests of lung function; the Fletcher breathlessness grading scale, the oxygen cost diagram and a visual analogue scale of dyspnoea; the Functional Limitations Profile (FLP); and the shortened 12 item General Health Questionnaire (GHQ-12), supplemented by the 7-item GHQ sub-scales of anxiety and severe depression. Low correlations were found between lung function and disability (-0.38, P less than 0.001), accounting for only 14% of the variance, and high correlations were found to exist between measures of dyspnoea and disability (-0.90, P less than 0.001). Major areas of disability and handicap included; household management, ambulation, sleep and rest, recreation and pastimes and work. Financial problems and difficulties, housing problems and problems of social isolation were also frequently reported. The paper goes on to discuss both the need for a more integrated approach to the care and rehabilitation of COAD patients and their families and for a complementary social perspective and approach to COAD and its treatment.
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PMID:Impairment, disability and handicap in chronic respiratory illness. 252 43

Twenty six hypoxaemic patients with severe and stable chronic obstructive pulmonary disease (COPD) were treated with continuous domiciliary oxygen for a six month period. The patients were evaluated 1, 3 and 6 months after the start of oxygen therapy. In addition to blood gas analysis, 15 coping skills were evaluated by the patient and by the nurse, who also rated the general activity of the patients. Depression was measured by Beck Depression Inventory (BDI) at the start of the trial and after six months' oxygen therapy. The general psychosocial response was meagre; no significant changes were observed in any psychosocial measures. The response was slightly better in younger and less hypoxaemic patients. We conclude that the psychosocial response to oxygen therapy in severely hypoxaemic COPD patients is limited.
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PMID:Psychosocial effects of continuous oxygen therapy in hypoxaemic chronic obstructive pulmonary disease patients. 260 99

The aim of the study was to evaluate the psychical state of 48 patients with chronic respiratory failure in the course of COPD qualified for home oxygen therapy. The psychical state was analysed using the following tests: thorough clinical history, J. Taylor's evident anxiety scale, H. Gough's adjective scale and psychological rehabilitation effectiveness scale according to J. Tylka. The study showed that the majority of patients demonstrated high levels of fear, depression and anxiety, lowered self evaluation, negative attitude toward work, lack of life aims and disbelief in therapy benefit. Correlation between degree of primary disease and lowered self-being could not be demonstrated. The decisive effect had socio-economic situation and individual traits.
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PMID:[Psychological state of patients with chronic obstructive pulmonary disease]. 263 Oct 50

Steroid therapy has become part of the adjunctive treatment for COPD patients in some settings. Emotional changes have been reported in some patients while on these medications, but whether these changes are associated with the pathophysiological state or a side effect of the medication is not known. In this study self-reports of depression and somatic complaints were compared between two groups of COPD patients, 20 not receiving steroids and 20 receiving steroids. Both groups demonstrated comparable levels of disease and somatic complaints. Mean FEV1 value for those not receiving steroids was 34% of predicted while the mean for those receiving steroids was 30% of predicted. Depression was found to be significantly higher (t = 11.21, df = 38, p less than 0.01) in the group receiving steroids when compared to those not receiving steroids using a Student's t test. The higher degree of depression among steroid treated COPD patients has implications for clinical practice. The emotional status of this group of patients needs to be monitored and interventions initiated when necessary.
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PMID:Depression, somatization and steroid use in chronic obstructive pulmonary disease. 276 12

Despite having fixed changes in lung structure, patients with chronic obstructive pulmonary disease and interstitial pulmonary fibrosis can be helped by pulmonary rehabilitation. They learn that shortness of breath is not to be feared but rather accepted and tolerated as a step toward eventual successful rehabilitation. They are taught to accept the reality of their disease but not to dwell on its limitations. They learn to fight depression and anxiety and to overcome their disability within a realistic framework. From the exercise program they build strength, endurance, and confidence and become more independent and mobile. Even very compromised patients can benefit from an intensive inpatient rehabilitation program.
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PMID:Inpatient pulmonary rehabilitation. A team approach to the more fragile patient. 281 9

Serious respiratory depression has been described in COPD patients receiving hypnotics during acute exacerbations. There are few studies quantifying the effects of hypnotics on oxygenation during sleep in patients with stable hypoxemic COPD. In this study, the effects of single therapeutic doses of nitrazepam and flunitrazepam on SaO2, apneas during sleep and other sleep variables were measured in 14 COPD patients. All patients used theophylline. Sleep-induced decrease in mean SaO2 was 1.3 percent after placebo, 1.4 percent after nitrazepam and 1.9 percent after flunitrazepam (no significant differences). Sleep apneas were not more common or longer after nitrazepam or flunitrazepam, but sleep quality seemed to improve. It is concluded that oxygenation during sleep in these nonobese patients with stable hypoxemic nonhypercapnic COPD, all on maintenance theophylline therapy, was affected very little by single therapeutic doses of nitrazepam or flunitrazepam.
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PMID:The effects of nitrazepam and flunitrazepam on oxygen desaturation during sleep in patients with stable hypoxemic nonhypercapnic COPD. 292 6


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