Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The response of peripheral blood and synovial fluid lymphocytes to three non-specific mitogens has been studied. The paired samples were taken from patients with a range of inflammatory arthritides. Unstimulated synovial fluid lymphocytes (SFL) tended to have a greater uptake of tritiated thymidine than had unstimulated peripheral blood lymphocytes (PBL). This background uptake of tritiated thymidine by SFL showed a positive correlation with the response these SFL then showed to the mitogens. A significant depression was observed in the SFL response to phytohaemagglutinin when compared with the paired PBL response; this was seen in both the rheumatoid arthritis and other inflammatory joint diseases groups. SFL responses to concanavalin A and pokeweed mitogen, although depressed in individual cases, failed to show a significant depression overall. Attempts to restore the SFL response to that of the paired PBL by removal of any possible blocking substance from the cell surface either by pre-incubation of SFL in tissue culture medium or by enzyme treatment were unsuccessful. This suggested that cell surface blockers were possibly not the reason for deficient SFL reponses and that other factors were involved.
 ...
PMID:Lymphocyte studies in rheumatoid arthritis. III. A comparative study of the responses of peripheral blood and synovial fluid lymphocytes to phytomitogens. 43 57

Borrelia burgdorferi has been implicated as the causative agent of borreliosis in dogs, which is characteristically a limb/joint disorder, but can be associated with multiple-organ dysfunction. Attempts to reproduce this disease by inoculating dogs with B burgdorferi have not been successful. In the study of this report, B burgdorferi from Ixodes dammini ticks was used to induce signs of limb/joint dysfunction, fever, anorexia, depression, and systemic infection in dogs. A pure culture of this bacterium from the blood of an infected dog has been used to fulfill Koch's postulates for B burgdorferi as the causative agent of limb/joint dysfunction associated with borreliosis in dogs.
 ...
PMID:Examination of Koch's postulates for Borrelia burgdorferi as the causative agent of limb/joint dysfunction in dogs with borreliosis. 128 18

The immunogenicity and efficacy of a commercial Borrelia burgdorferi bacterin was evaluated for stimulation of the host immune response and protection against clinical disease associated with experimentally induced borreliosis in dogs. A total of 30 vaccinated and 24 control dogs were used in 3 separate studies. The vaccine was given IM as two 1-ml doses separated by a 3-week interval. Two weeks or 5 months following the last vaccination, the dogs were challenge inoculated with 7 daily doses of a virulent preparation of a B burgdorferi field isolate through intraperitoneal, subcutaneous, and intradermal routes with or without glucocorticoid administration at the same time. The development of B burgdorferi spirochetemia and clinical disease in the dogs after challenge exposure was studied. Serum samples were obtained from the dogs at various times during the study for serum neutralizing antibody determination and protein immunoblot antibody assay against various geographic isolates of B burgdorferi. Challenge exposure induced limb/joint disorder, fever, anorexia, signs of depression, and B burgdorferi spirochetemia in the nonvaccinated control dogs. The vaccine was found to elicit cross-reactive serum neutralizing and protein immunoblot antibody responses in dogs to various isolates of B burgdorferi and to protect the vaccinated dogs against experimentally induced borreliosis.
 ...
PMID:Immunogenicity and efficacy study of a commercial Borrelia burgdorferi bacterin. 822 28

The authors analyse the anatomic character and the functional consequences of the posterior depression-separation in ankle fractures. The posterior depression fracture was present in 20 per cent of the ankle fractures of the studied series. The major depression was noticed 1 by 3. The lesion justified a specific operation. Its presence had also to be searched in rotation fractures treated conservatively, when the lateral malleolus was uncorrectly reduced. These two situations unnoticed or neglected create an incontinence of the talus leading to a triple desaxation, even if it does not appear on usual x-ray views. Tomographic sagittal x-ray views are on that score an important contribution to the diagnostic. Ankles showing such a residual defect deteriorated to an early articular narrowing during the first 6 months and to arthrosis during the first or second year.
 ...
PMID:[Posterior depression-separation fracture in bimalleolar fractures]. 215 78

Possible targets of quinolone toxicity include the juvenile joint, the kidney, the central nervous system (CNS), the eye, and the cardiovascular system. In immature animals all quinolones studied cause arthropathies of the major diarthrodial joints. Arthropathies have also developed in adult dogs after 12 months of pefloxacin treatment. At high doses the quinolones exert effects on renal function that are related to a foreign-body reaction caused by crystals; nephropathologic changes seem not to occur without crystalluria. In humans quinolones can have various CNS effects. The subcellular "substrate" for these effects is unknown. Further understanding of severe CNS reactions (confusion, hallucination, anxiety, agitation, nightmares, convulsive seizures, and depression) is needed. Pefloxacin causes cataracts in dogs after treatment for 8-12 months. Low-dose quinolones (administered as an intravenous bolus) cause pronounced but transient systolic hypotension in dogs and cats; cardiovascular effects may be mediated by histamine release. Quinolones inhibit the bacterial enzyme DNA gyrase. To exclude the possibility of damage to mammalian DNA, mutagenicity studies have been performed. Since all but two tests (which may give false-positive results) have been negative, quinolones appear to be nonmutagenic. Photosensitivity has occurred in humans given quinolones. Drug interactions can be clinically important.
 ...
PMID:Specific toxicologic aspects of the quinolones. 327 89

With arthroscopy cartilage changes are being detected more and more frequently which must be classified as early arthrosis. Similar changes (stage II) could be induced in 17 rabbits 6 weeks after lateral meniscectomy. Extraction (4M-GuHcl) and gel chromatography (Sepharose 2B) of 35S-proteoglycans resulted in typical elution profiles. Aggregates were remarkably, monomers slightly reduced, and a third population of nonaggregated proteoglycans increased. In 81 patients undergoing knee arthroscopy 98 small cartilage biopsies were taken from standardized regions and analysed biochemically. Elution profiles were correlated to anamnestic and clinical data (Wilcoxon-test, cluster analyses). Irrespective of the grade of osteoarthrosis (OA) the ratio of aggregated and nonaggregated 35S-proteoglycans varied. Almost half of the samples from macroscopically "normal" cartilage revealed a depression of aggregates. No correlation to anamnestic or clinical data was found. The profiles probably represent different metabolic stages in developing OA. By analysis of 35S-proteoglycans in cartilage biopsies it seems possible to detect early metabolic changes at the onset of osteoarthrosis.
 ...
PMID:[Early detection of arthrotic changes in animal experiments and clinical medicine]. 375 49

This paper describes our experience with the use of razoxane (ICRF 159), a new anti-mitotic drug, in the treatment of thirty-six patients with severe psoriasis. The drug has proven highly effective both in cutaneous and in arthropathic disease. The drug is well tolerated by patients and appears to be free of hepatotoxicity. However, it causes depression of the neutrophil leukocyte count, an effect which is entirely dose-dependent; the hazard to patients can be minimized by careful supervision of therapy.
 ...
PMID:Razoxane (ICRF 159) in the treatment of psoriasis. 737 Jan 78

The association of juvenile diabetes mellitus (DM), diabetes insipidus (DI), optic atrophy (OA) and sensorineural deafness (D) is known as DIDMOAD or Wolfram syndrome. Aside from these four cardinal features, a wide variety of abnormalities of the nervous system, urinary tract and endocrine glands have been described in this syndrome. In this report, the clinical features of six patients with DIDMOAD syndrome are presented. All six patients had DM. Five of the six patients had DI, five OA and five displayed abnormal audiogram findings. In addition, two had goiter, two delayed puberty, one seizure and one mental retardation with depression attacks. Urinary tract dilatation was recorded in five patients. Four patients developed typical complications of DM. One of them had overt nephropathy and arthropathy despite the short duration of DM. In addition, this patient had diabetic retinopathy, which is considered to be rare in this syndrome.
 ...
PMID:Various clinical aspects of DIDMOAD (Wolfram) syndrome. 750 61

Depressed tibial plateau fractures in 13 patients were treated under arthroscopic control. In 3 patients, bone autograft was used; in the remaining 10, hydroxyapatite (HAP) grafts were used. The depression of the articular surface was managed by elevation of the subchondral plate through a small window. Assisted by fluoroscopy, we corrected and performed the grafting under arthroscopic control. Follow-up periods averaged 5 years 6 months for the autograft and 18 months for the HAP grafts. At the conclusion of the follow-up period, x-ray radiographs and computed tomography (CT) scan showed no evidence of arthrosis and knee motion was normal. There were no significant differences between the two groups. The interporous spaces showed new bone formation on closed biopsy 6 months postoperatively.
 ...
PMID:Arthroscopic restoration of depressed tibial plateau fractures using bone and hydroxyapatite grafts. 844 16

Tibial plateau fractures in 17 patients were managed arthroscopically, using interporous hydroxypatite (HA) as a bone graft substitute. Soft-tissue repair and intra-articular lavages were carried out arthroscopically, and depression of the articular surface was done by elevation of the subchondral plate by the bone compactor through a small window under image intensification and filling with HA through the tibial outer rim. Follow-up periods averaged 2 years and 6 months. According to roentgenograms and computed tomograms no development of arthrosis could be found. All of the patients have been followed to fracture union and have returned to their previous activity levels.
 ...
PMID:Use of arthroscopy and interporous hydroxyapatite as a bone graft substitute in tibial plateau fractures. 877 10


1 2 3 4 5 6 Next >>