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The present communication studies the testicular function during suspension of the testicle to the scrotal neck. The material consisted of 28 dogs: 20 test dogs and 8 controls. In the 20 test dogs, the 2 testicles were suspended to the skin at the scrotal neck by 2-3 silk stitches. After one year, the testiculo-scrotal suspension was released. During testicular suspension, there was significant drop in the scrotal-rectal temperature difference. Semen quality showed gradual deterioration so that by the 12th month, 80% of the test dogs were azoospermic. There was a significant drop of serum testosterone and elevation of serum prolactin. 8 of the 20 test dogs which produced pregnancy when mated before testicular suspension, failed after suspension. After release of testicular suspension by 3 months, scrotal-rectal temperature difference, sperm count and morphology and hormonal assay showed normal levels. Mating of the same 8 dogs produced pregnancy. In conclusion, testicular suspension leads to spermatogenic depression and infertility which are reversible.
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PMID:Testicular suspension: effect on testicular function. 177 44

The Soviet research on infant mortality indicated that short birth intervals (less than 1.5 years) and high birth orders seemed to pose a high mortality risk to children in the 1st year of life; the risk of premature birth was almost twice as high. Some data also showed that in a region of Uzbekistan 35.5% of urban and up to 56.7% of rural child mortality under 1 was in families with many children. 16-25% of women in rural areas of the Central Asian republics give birth twice a year, i.e., the intergenetical interval is less than 1 year. Pregnancy and birth complications occur in 66% of multiparous women in Uzbekistan. In 20.7% of young Turkmen women pregnancy occurs during the 1st 3 months after the death of a child during the perinatal period. Induced abortion sometimes leads to irreversible infertility and to benign and malignant diseases of the breast and the reproductive system. Premature birth is 1.7-2.5 times more likely among women whose 1st pregnancy ended in abortion or who have had 3 or more induced abortions. In 1989 the number of abortions/1000 women of reproductive age was 99.8. Every 5th abortion that occurred in primigravidas 17 was outside of hospitals. In Central Russia, Estonia, and Georgia women under 35 want about 2 children. In Central Asia and Kazakhstan 6-7 children/family is the rule. 15-45% of pregnancies were unplanned in these republics. 27% of multiparous mothers in Kazakhstan use contraceptives. In young Turkmen families contraceptive prevalence was 29.8%. In Russia 69.5% of married women aged 25-35 are in need of contraceptives. 24-27% of girls aged 15-19 in Moscow had sexual experience, and 41.9% among college students. The average age of starting sex was 16.4 years among female students. Abortions occur in 15-21% in the 15-19 age group. Complications after abortion occur in 59.4% of teenagers including depression in 9.1% of them.
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PMID:[Family planning and maternal and child care in present-day society]. 178 71

The present study investigated the problem of whether or not the intake of an Western-style diet will induce within the host a specified hormonal change that increases the risk for breast cancer (BC). The key observations obtained are as follows: 1) The risk for BC in Japan has been increasing for the last 20 years in parallel with the Westernization of dietary habits (increase of fat and animal protein in the diet). 2) A Japanese BC patient is distinguishable from a corresponding normal control by (a) an increase of waist/hip ratio (more specifically, an increase of abdominal fat) and (b) a decrease in the number of live births (relative infertility). Height, weight and height-adjusted weight all cannot distinguish the former from the latter. 3) The former is also distinguishable from the latter by dual steroidal disorders of ovarian dysfunction (progesterone depression) and hypercorticoidism, as revealed by a case control comparison of urinary steroid excretions. 4) The long-term maintenance of an experimental mouse on a fat-rich diet increased abdominal fat weight at an adult age, but not at a young age. 5) In the same experiment, the fat-rich diet produced a reduction of plasma progesterone at an early stage, and also produced dual changes of progesterone depression and corticosterone stimulation at a late stage of experiment. Plasma estradiol was little affected by an excess of dietary fat. 6) In an adult mouse, the weight of abdominal fat was increased by corticosterone treatment and was decreased by estradiol treatment. The suppressive effect of estradiol on abdominal fat weight was dose-dependent. In conclusion, our findings seem to suggest the possibility that a fat rich diet may produce dual steroidal disorders of ovarian dysfunction and hypercorticoidism which in turn will open the way to breast carcinogenesis by activating 2 proto-oncogens at the initiation and promotion steps.
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PMID:Nutrition and breast cancer risk in Japan. 206 29

There is increasing evidence that a behavioral treatment approach might be efficacious in the treatment of the emotional aspects of infertility and may lead to increased conception rates. The first 54 women to complete a behavioral treatment program based on the elicitation of the relaxation response showed statistically significant decreases in anxiety, depression, and fatigue as well as increases in vigor. In addition, 34% of these women became pregnant within 6 months of completing the program. These findings established a role for stress reduction in the long-term treatment of infertility. They further suggest that behavioral treatment should be considered for couples with infertility before or in conjunction with reproductive technologies such as intrauterine insemination and gamete intrafallopian transfer.
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PMID:The mind/body program for infertility: a new behavioral treatment approach for women with infertility. 224 49

The aim of this research was to study the effect of suspected infertility on psychological functioning, comparing men who suspect that they are infertile (N = 107) with men who have no such suspicion (N = 30). Infertile men had lower self-esteem, higher anxiety and showed more somatic symptoms than fertile men. The effects of moderating variables on the psychological functioning of the subfertile men were analysed. The findings were that causality of infertility, feelings of hopelessness and global attribution were related to sexual inadequacy. Depression was uniquely related to stress of infertility and global attribution. Global attribution, though predictive of psychological consequences, was not affected by the objective variables of infertility.
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PMID:Psychological aspects of male infertility. 233 55

The hypothesis that increased estradiol production may be the cause of impaired spermatogenesis in infertile men with idiopathic oligozoospermia was tested by administering the aromatase inhibitor, testolactone, and by assessing its effects on sperm output and fertility. Our study was a randomized, placebo-controlled double-blind crossover trial. Subjects (n = 25) with infertility due to unexplained oligozoospermia were given testolactone (2 g/day) or placebo for 8 months followed by crossover to the other treatment for an additional 8 months. Total estradiol and testosterone levels during testolactone exposure did not change from basal and placebo values. However, sex hormone-binding globulin binding capacity consistently decreased (30%, p less than 0.01) and free testosterone levels increased (36%, p less than 0.01). Free estradiol values increased but not significantly. Additionally, LH and FSH serum levels increased by 15% and 20%, respectively (p less than 0.05), and 17 alpha-hydroxyprogesterone values increased by 90% (p less than 0.05) during drug administration. Sperm output and semen quality remained unchanged during either testolactone or placebo treatment, and no pregnancies occurred during the 16-month study. These data suggest that chronic administration of testolactone at this dose fails to maintain aromatase inhibition despite depression of 17,20-desmolase activity with elevated 17 alpha-hydroxyprogesterone and depressed SHBG binding capacity with elevation of free testosterone. Testolactone is not efficacious in the treatment of idiopathic oligozoospermic infertility.
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PMID:Treatment of men with idiopathic oligozoospermic infertility using the aromatase inhibitor, testolactone. Results of a double-blinded, randomized, placebo-controlled trial with crossover. 266

Women who undergo treatment for infertility frequently report depression, but it is crucial to distinguish between subjective distress, symptoms, and clinical depressive disorders. In the initial assessment of a prospective, longitudinal study, 59 women presenting for infertility treatment were compared with 35 women presenting for routine gynecological care. Infertility patients and controls were not significantly different on self-report measures of partner satisfaction, sexual functioning, or self-esteem. There was also no difference in psychiatric symptomatology, or in the percentage of subjects who were currently experiencing or had ever experienced a major depressive episode. However, the infertility patients perceived themselves to have been already quite affected by their inability to conceive. For instance, 49.2% reported changes in their sexual functioning and 74.6% reported changes in their mood.
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PMID:Mood disorders, psychiatric symptoms, and distress in women presenting for infertility evaluation. 277 96

Authors present the statistics of the diagnosis and treatment of infertile patients who visited the outpatient clinic of the Department of Obstetrics and Gynecology, School of Medicine, University of Occupational and Environmental Health, Japan throughout 1985. The number of primary infertility (78) was greater than that of secondary infertility (63). The average age and the duration of infertility were 30.5 y. old/3.86 y. (primary) and 31.6 y. old/3.59 y. (secondary), respectively. The most frequent cause of infertility was ovarian-endocrine factor both in primary and secondary infertilities. The second cause was the male factor in primary infertility in spite of the idiopathic factor in secondary infertility. Tubal disorder as a cause was relatively few in both infertilities. So-called open laparoscopy was performed on 11 patients, with little hope of cure. In eight of these patients, disorders of tubal patency and endometriosis, which were not found by hysterosalpingography and hydrotubation before laparoscopy, were discovered for the first time. In twenty pregnancies at the day of statistics, the number of secondary infertility (13) was greater than that of primary infertility (7). All pregnant cases were under 35 years of age and under 5-year of infertility duration at the initial visit to our outpatient clinic. The number 1 cause of infertility was ovarian-endocrine factor. In eight pregnant cases, hysterosalpingography was performed in the same or one cycle before the pregnant cycle. According to the summation of the questionnaire of 65 infertile patients, most of infertile patients were affirmative to in-vitro-fertilization and embryo transfer. Depressive and neurotic tendencies were not remarkable at that time by Self-Rating-Depression Scale (SDS) and Cornell Medical Index (CMI) in 42 infertile patients.
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PMID:[Statistics on the diagnosis and treatment of infertile patients--psychologic examination and analysis of the questionnaire]. 294 44

Potential long-term effects of psychological dysfunction associated with infertility were investigated in a descriptive study of 32 previously infertile couples. Comparison was made with the performance of 20 never infertile couples matched for age, number of children, education, and income level, using a standard psychological assessment tool, the Hopkins symptom check list. While infertile, women had slightly elevated mean scores on three subscales: depression, interpersonal sensitivity, and hostility. After resolution of infertility, these scores did not improve. In addition, depression scores were elevated among the previously infertile women compared with a matched, never infertile group. Infertile men scored within the normal range for depression and interpersonal sensitivity and had a borderline mean score for hostility, which was markedly reduced after a normal pregnancy.
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PMID:Psychological status of previously infertile couples after a successful pregnancy. 323 Apr 69

The purpose of this investigation was to examine the psychologic test results of women diagnosed with infertility as compared with the general population of women. The infertile group consisted of 150 women, whereas the control group included 50 women. Both groups were similar in regard to age and number of years married. The tests administered were: the 16 Personality Factor, the IPAT Anxiety Scale, the IPAT Depression Scale, the Tennessee Self-Concept Scale, and the Internal-External Scale (locus of control). Scores on a total of 41 test variables did not differ significantly between the two groups. In fact, the means and standard deviations for all variables were remarkably similar. This study concludes that significant emotional maladjustment is no more prevalent in women coping with infertility than for the general population of women. Results from this investigation cast doubt on the historical assumption that stress may be a causal factor in infertility.
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PMID:An investigation of the relationship between emotional maladjustment and infertility. 333 82


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