Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To examine the effect of human immunodeficiency virus antibody testing on suicidal ideation among physically asymptomatic subjects at perceived risk for infection, 244 men and 57 women completed the Beck Depression Inventory 2 weeks before and 1 week and 2 months after notification. All subjects received extensive pretest and posttest counseling. Among the 49 seropositive subjects, rates of suicidal ideation on item 9 of the Beck Depression Inventory were 28.6% at entry and 27.1% and 16.3% at the two follow-up assessments; none reported increased suicidal ideation at 2 months. Among the 252 seronegative subjects, suicidal ideation decreased from 30.6% at entry to 17.1% and 15.9% at 1 week and 2 months after notification, respectively. Suicidal ideation correlated with modified Beck Depression Inventory scores (r = .50 to .55). Among the 4.7% of seropositives and seronegatives with suicidal wishes or intent at any assessment, average modified Beck Depression Inventory scores (mean, 17.1) suggested a clinical depression.
 ...
PMID:Suicidal ideation and HIV testing. 236 28

Twenty-four patients with various degrees of human immunodeficiency virus (HIV)-associated immunodeficiency were treated with zidovudine for up to 6 months. Nineteen of these patients had persistent depression of delayed-type hypersensitivity (DTH) responses prior to commencing therapy. In 11 of these 19 patients (58%) there was sustained improvement of DTH responses with the maximal effect occurring at approximately 3 months after therapy was started. DTH declined after 3 months but remained significantly higher than baseline at 6 months. Patients who did not have a sustained increase in DTH responses had more severe disease than those that did. Blood CD4+ T-cell counts increased in the majority of patients on zidovudine therapy, but varied independently of DTH responses. Epidermal Langerhans cell density was lower in HIV-infected patients than controls but also varied independently of DTH responses before and after zidovudine therapy. We suggest that sequential measurement of DTH responses is a valuable means of monitoring the restoration of cell-mediated immune responses by zidovudine in some HIV-infected patients. Our findings also demonstrate the need to define the processes involved in the restoration of DTH responses as this may lead to new approaches to the therapeutic manipulation of cell-mediated immune responses in HIV-infected patients.
 ...
PMID:Correction of human immunodeficiency virus-associated depression of delayed-type hypersensitivity (DTH) after zidovudine therapy: DTH, CD4+ T-cell numbers, and epidermal Langerhans cell density are independent variables. 230 80

To evaluate the effectiveness of human immunodeficiency virus (HIV) testing and counseling among homosexual and bisexual men participating in the San Francisco City Clinic Cohort, compared behavioral data from 181 men who learned their HIV antibody status between 1985 and 1987 with data from 128 men who were tested but declined to receive their results. Overall, significant declines in risk indices for unprotected receptive and insertive anal intercourse occurred between 1983-1984 and 1986-1987, but these declines were independent of both knowledge of HIV status and actual serostatus. Those who chose to learn their HIV status were also no more likely to report depression or to learn their HIV status were also no more likely to report depression or anxiety subsequent to testing. Regression analyses showed no relationship between length of time since learning one's HIV status, mental health symptoms, and the persistence of high-risk behavior in 1986-1987. Although these results do not negate the value of HIV testing and counseling, they suggest that other motivating factors such as frequent access to risk-reduction information may provide sufficient impetus for behavioral change.
 ...
PMID:High-risk sexual behavior and knowledge of HIV antibody status in the San Francisco City Clinic Cohort. 234 Aug 17

The relationship between anxiety and depression, and serum and cerebrospinal fluid (CSF) immune parameters was studied in 98 patients randomly selected from those undergoing routine medical evaluation for human immunodeficiency virus seropositivity as part of the U.S. Air Force's mandatory screening program. A total of 95% of the sample did not have acquired immunodeficiency syndrome (AIDS). The population was subdivided into high and low anxiety or depression groups for statistical purposes. Significant correlations were obtained between high Hamilton Rating Scale for Depression scores (greater than 10) and CSF nucleated cell count and protein levels. High Hamilton Rating Scale for Anxiety (greater than 10) scores were positively correlated with CSF nucleated cell count and absolute CD4a counts. There were no statistically significant group differences with respect to mean laboratory values between high and low anxiety or depression subgroups. Serum viral titers to Epstein-Barr virus and cytomegalovirus were not correlated with anxiety or depression scores. These results suggest a complex relationship between CSF and systemic immune abnormalities and degree of anxiety and depression.
 ...
PMID:Associations between cerebrospinal fluid parameters and high degrees of anxiety or depression in United States Air Force personnel infected with human immunodeficiency virus. 234 94

We examined psychiatric correlates of human immunodeficiency virus (HIV) infection in a major risk group for acquired immunodeficiency syndrome, men with hemophilia. A central goal was to identify psychosocial factors associated with increased vulnerability to psychiatric distress after infection with HIV. Seventy-five hemophiliacs, 31 of whom were HIV seropositive (HIV+), were studied. The HIV+ men had elevated depression, anxiety, and anger-hostility symptom scores relative to those of men who were seronegative for HIV. There were no additional symptom differences among men according to infection stage or clinical severity of hemophilia. Men with any of eight psychosocial characteristics were particularly susceptible to effects of infection on mental health: a personal history of psychiatric distress before HIV diagnosis; familial psychiatric history; a high school education or less; low social support from one's wife; low family support; low friend support; a poor sense of mastery over one's life; and experiencing recent life events involving loss. The HIV+ men with one or more such characteristics were highly symptomatic; remaining HIV+ men had significantly lower symptom levels, similar to the low levels noted in the men seronegative for HIV. The findings provide initial empiric support for the notion that clinical services to alleviate emotional distress should be targeted to intervene on HIV+ persons' psychosocial assets and liabilities.
 ...
PMID:Infection with human immunodeficiency virus and vulnerability to psychiatric distress. A study of men with hemophilia. 237 44

Monocytes/macrophages play a central role in the afferent and efferent limbs of the immune system. Macrophages perform several immunological functions both in vivo and in vitro, including antigen presentation, tumor cell killing, phagocytosis, and bacterial and viral killing. Acquired immunodeficiency syndrome (AIDS), a disease characterized by a profound immunodeficiency, induces a wide range of neuropsychological abnormalities. The occurrence of severe psychological disturbances, including stress, depression, and anxiety increase psychological and physical indices of morbidity among patients. Stress influences several immunological responses in man and animals and is usually accompanied by altered blood levels of various CNS-related peptides or neurohormones. Monocytes/macrophages express surface receptors for different CNS-secreted molecules. In ARC and AIDS patients abnormal neuropeptide levels may be related to severe psychological disturbances. Neuropeptides and neurohormones may play a central role in stressed HIV-1-infected patients by affecting monocyte-macrophage functions, which may further trigger disease progression and immunologic deficiency. It is hypothesized that stress reactions lead to altered release of neurohormones and/or neuropeptides which affect monocyte-macrophage functions and favor progression of HIV-1-related disease.
 ...
PMID:Stress-related neuroimmunomodulation of monocyte-macrophage functions in HIV-1 infection. 240 70

A retrospective review of the records of 755 patients seen by a psychiatric consultation-liaison service in a general hospital was performed. The authors found that 87% of manic patients and 38% of depressed patients had a diagnosis of organic mood disorder. The most frequent precipitants of mania were corticosteroids, human immunodeficiency virus (HIV) infection, and temporolimbic epilepsy. The most frequent precipitants of depression were stroke, Parkinson's disease, and HIV infection.
 ...
PMID:Causes of organic mood disorder. 252 Oct 90

The three-dimensional structure of human rhinovirus 14 has a deep surface depression or "canyon" encircling each of the twelve fivefold vertices. The canyon's surface is inaccessible to the broad antigen binding region of antibodies, permitting conservation of residues that might be required for host cell receptor recognition without danger of attack by the host's immune system. In contrast, the exposed surface features, where neutralizing antibodies are known to bind, change rapidly under pressure from the host's immune system. It was, therefore, hypothesized that this depression was the site of receptor attachment. Similar, but smaller, depressions had been observed previously on both the hemagglutinin and neuraminidase spikes of influenza virus. These have also been shown to be the site of host cell interaction. Although support for the canyon hypothesis was only circumstantial in the first place, there are now extensive confirmatory data. These include site-specific mutations of residues in the canyon and conformational changes induced in the canyon by the binding of small organic molecules, all of which alter receptor attachment. The strategy used in human rhinovirus 14 to protect the viral receptor attachment site from immune surveillance may be utilized not only in other picornaviruses but also in many other types of viruses including human immunodeficiency virus.
 ...
PMID:The canyon hypothesis. 256 Sep 13

The three-dimensional structure of human rhinovirus 14 has a deep surface depression or "canyon" encircling each of the twelve 5-fold vertices. The canyon's surface is inaccessible to the broad antigen binding region of antibodies, permitting conservation of residues that might be required for host cell receptor recognition without danger of attack by the host's immune system. In contrast, the exposed surface features, where neutralizing antibodies are known to bind, change rapidly under pressure from the host's immune system. It was, therefore, hypothesized that this depression was the site of receptor attachment. Similar, but smaller, depressions had been observed previously on both the hemagglutinin and neuraminidase spikes of influenza virus. These have also been shown to be the site of host cell interaction. Although support for the canyon hypothesis was only circumstantial in the first place, there are now extensive confirmatory data. These include site-specific mutations of residues in the canyon and conformational changes induced in the canyon by the binding of small organic molecules, all of which alter receptor attachment. The strategy used in human rhinovirus 14 to protect the viral receptor attachment site from immune surveillance may be utilized not only in other picornaviruses but also in many other types of viruses including human immunodeficiency virus.
 ...
PMID:The canyon hypothesis. Hiding the host cell receptor attachment site on a viral surface from immune surveillance. 267 Sep 20

In an area endemic for visceral leishmaniasis, 16 patients with human immunodeficiency virus (HIV) infection developed the disease. All belonged to populations at risk for AIDS (15 were intravenous drug abusers). Five patients fulfilled the criteria for full-blown AIDS, and two more fulfilled them after diagnosis of leishmaniasis. All presented with the classic manifestations of visceral leishmaniasis, but leishmania serology was negative in 15 patients (93%). Leishmania donovani amastigotes were identified in the bone marrow in all cases. Most patients responded initially to treatment with pentavalent antimonial drugs, but seven (43%) followed a chronic course, with multiple relapses in five, despite alternative treatments. Visceral leishmaniasis occurred in patients with different levels of depression of the CD4 to CD8 lymphocyte ratio. Mortality was 37% (six patients) and was independent of the chronic-relapsing course of the disease. In no case was leishmaniasis the primary cause of death. Our data establish that visceral leishmaniasis is an opportunistic infection in HIV-infected patients, and we suggest that in endemic areas it should be considered an indicator disease for the diagnosis of AIDS.
 ...
PMID:Visceral leishmaniasis (kala-azar) as an opportunistic infection in patients infected with the human immunodeficiency virus in Spain. 210 72


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>