Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
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Query: UMLS:C0011570 (
depression
)
172,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Histomoniasis
was diagnosed in a flock of 6-wk-old commercial chickens. Clinical signs included
depression
, stilted gait, inappetence, and a slight increase in mortality. At necropsy, there were pale-yellow to dark-gray circular and depressed necrotic lesions in the liver. The ceca were enlarged and impacted with caseous cores. Cecal worms were not observed either at necropsy or on histopathology. Histomonads were demonstrated microscopically within the bursa of Fabricius in addition to the liver, ceca, and spleen. This is the first report of the presence of histomonads in the bursa of Fabricius in commercial chickens.
...
PMID:Histomoniasis in the bursa of fabricius of chickens. 1552 99
Histomonosis
in chickens often appears together with colibacillosis in the field. Thus, we have experimentally investigated consequences of the co-infection of birds with
Histomonas meleagridis
and avian pathogenic
Escherichia coli
(APEC) on the pathology, host microbiota and bacterial translocation from the gut. Commercial chicken layers were infected via oral and cloacal routes with
lux
-tagged APEC with or without
H. meleagridis
whereas negative controls were left uninfected. Except one bird, which died due to colibacillosis, no clinical signs were recorded in birds infected with bioluminescence
lux
gene tagged
E. coli.
In co-infected birds,
depression
and ruffled feathers were observed in 4 birds and average body weight gain significantly decreased. Typhlitis caused by
H. meleagridis
was present only in co-infected birds, which also had pronounced microscopic lesions in systemic organs such as liver, heart and spleen. The 16S rRNA gene amplicon sequencing showed that in co-infected birds, corresponding to the severity of cecal lesions, microbial species richness and diversity in caeca greatly decreased and the abundance of the
Escherichia
group,
Helicobacter
and
Bacteroides
was relatively higher with a reduction of commensals. Most of the shared Amplicon Sequencing Variants between cecum and blood in co-infected birds belonged to
Pseudomonas, Staphylococcus, and
members of
Enterobacteriaceae
while those assigned as
Lactobacillus
and members of
Ruminococcaceae
and
Lachnospiraceae
were found mainly in negative controls. In infected birds,
E. coli
in the cecal lumen penetrated into deeper layers, a phenomenon noticed with higher incidence in the dead and co-infected birds. Furthermore, numbers of
lux
-tagged
E. coli
in caeca were significantly higher at every sampling date in co-infected birds. Altogether, infection of layers with
H. meleagridis
and
E. coli
resulted in more severe pathological changes, dramatic shift in the cecal mucosa-associated microbiota, higher tissue colonization of pathogenic bacteria such as avian pathogenic
E. coli
in the gut and increased penetration of
E. coli
from the cecal lumen toward peritoneum. This study provides novel insights into the parasite-bacteria interaction
in vivo
highlighting the role of
H. meleagridis
to support
E. coli
in the pathogenesis of colibacillosis in chickens.
...
PMID:Co-infection of Chicken Layers With
Histomonas meleagridis
and Avian Pathogenic
Escherichia coli
Is Associated With Dysbiosis, Cecal Colonization and Translocation of the Bacteria From the Gut Lumen. 3319 38
