Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The recent American Academy of Neurology position paper by Franklin, "Opioids for chronic noncancer pain," suggests that the benefits of opioid treatment are very likely to be substantially outweighed by the risks and recommends avoidance of doses above 80-120 mg/day morphine equivalent. However, close reading of the primary literature supports a different conclusion: opioids have been shown in randomized controlled trials (RCTs) to be highly effective in the treatment of chronic nonmalignant pain; long-term follow-up studies have shown that this effectiveness can be maintained; and effectiveness has been limited in many clinical trials by failure to take into account high variability in dose requirements, failure to adequately treat depression, and use of suboptimal outcome measures. Frequency of side effects in many RCTs has been inflated by overly rapid dose titration and failure to appreciate the high interindividual variability in side effect profiles. The recent marked increase in incidence of opioid overdose is of grave concern, but there is good reason to believe that it has been somewhat exaggerated. Potential causes of overdose include inadequately treated depression; inadequately treated pain, particularly when compounded by hopelessness; inadvertent overdose; concurrent use of alcohol; and insufficient practitioner expertise. Effective treatment of pain can enable large numbers of patients to lead productive lives and improve quality of life. Effective alleviation of suffering associated with pain falls squarely within the physician's professional obligation. Existing scientific studies provide the basis for many improvements in pain management that can increase effectiveness and reduce risk. Many potentially useful areas of further research can be identified.
...
PMID:Opioids for chronic noncancer pain: To prescribe or not to prescribe-What is the question? 2613 43

People waiting for organ transplants can experience a range of emotions including helplessness, hopelessness and depression, often made worse by financial difficulties, psychologist Patricia Franklin told a recent Royal College of Nursing Transplant Forum conference.
...
PMID:Emotional responses to transplant operations. 2752 82

Psychotherapeutic treatments that focus on improving the relational processes between mothers with postpartum depression (PPD) and their infants, as well as the mother's individual therapeutic needs, have a great potential to positively impact the mother, her infant, and their relationship (K.J. Nylen, T.E. Moran, C.L. Franklin, & M. O'Hara, 2006). Utilizing pilot data from an evaluation of a home-based dyadic therapy for mothers with PPD and their infants, this article reports on a recent academic-community partnership study. The effectiveness of the intervention was examined, specifically regarding changes in mother's mood, parenting experience, and relationship with her infant. In addition, associations were examined among maternal self-report variables measuring change from pre- to posttreatment in PPD, psychological distress, and maternal perceptions of parenting and those variables measuring change in observer ratings of maternal-infant interactions. Results showed improvements in mothers' depression, distress, and perceptions of parenting as well as many ratings of mothers' interactions with their infants. However, only improvements in maternal perceptions of parenting, such as maternal self-esteem and parenting stress, were associated with better mother--infant interactions. Importance of this research for the field of infant mental health as well as clinical implications are discussed.
 ...
PMID:Evaluating a home-based dyadic intervention: Changes in postpartum depression, maternal perceptions, and mother-infant interactions. 2852 Jan 45

Herbert Hoover, the archetypal self-made man, was the 31st president of the United States. His term in office was overwhelmed by the Great Depression and he was defeated by Franklin Delano Roosevelt in the 1932 November presidential election. His post-presidential years were spent writing and serving 4 subsequent presidents. Near the end of his life, he underwent a cholecystectomy for symptomatic gallstones and a colectomy for colon cancer. His health care was complicated by the development of cirrhosis and recurrent gastrointestinal bleeding. After his 90th birthday, he died in October 1964 from massive bleeding due to a Dieulafoy lesion of the gastric cardia. This manuscript will review the details of his health and the physicians who cared for Hoover during his final years.
 ...
PMID:The Final Illness of Herbert Hoover. 3311 64


<< Previous 1 2