Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The exacerbation of a chronic gingivitis during pregnancy was confirmed in a group of 24 pregnant patients who were observed at the 14th and 30th weeks of pregnancy and postpartum. This exacerbation occurred despite a fall in the amount of plaque accumulation and confirmed that during pregnancy some factor in addition to plaque is involved in the increased inflammation. Using in vitro methods, it was shown that during pregnancy there is a depression of maternal T-cell responsiveness and it is suggested that this depression of the cell-mediated immune response could be a factor in the altered responsiveness of the gingival tissues to plaque. However lymphocytes responses to Veillonella alkalescens ultrasonicate (a plaque antigen) were generally poor and it was not possible to demonstrate any significant difference between the altered responsiveness of maternal lymphocytes to Veillonella and those of nonpregnant controls.
 ...
PMID:Maternal T-lymphocyte response and gingivitis in pregnancy. 31 16

This study correlates the prevalent oral disease findings in 390 patients seropositive for human immunodeficiency virus type 1 (HIV-1) with their level of staging (Walter Reed) and depletion of peripheral helper T lymphocytes (CD4+). Chronic lymphadenopathy of the head and neck was a common finding (59.2%) that occurred early in staging progression and did not correlate with depression of helper T-cell levels. Of the three prevalent oral disease findings (oral hairy leukoplakia (OHL), candidiasis, necrotizing ulcerative gingivitis [NUG]) only OHL and NUG were significantly correlated with helper T-cell depletion. The occurrence of visually detectable OHL and NUG corresponds to depletion of peripheral helper T-lymphocyte values in a range of 157 to 299 cells/mm3. This range may represent a more accurate value for biologically significant lymphocyte depletion than the Walter Reed value of 400 cells/mm3. The presence of OHL showed a weak statistical correlation with staging progression, indicating deteriorating immunoregulation. No cases of Kaposi's sarcoma or other HIV-1-associated oral diseases were observed in the sample population, regardless of the patient's staging category or peripheral helper T-lymphocyte count.
 ...
PMID:Correlation of oral disease with the Walter Reed staging scheme for HIV-1-seropositive patients. 153 56

In a child with Down's syndrome (DS) and her sibling, host immune responses were evaluated under experimental gingivitis conditions. The children live in the same environment under identical conditions. In the DS child an earlier and more extensive gingival inflammation than in her sibling had been observed. Investigation of nonspecific host defense mechanisms revealed identical results in both children for the phagocytosis and intracellular killing of Candida albicans by polymorphonuclear leukocytes in crevicular washings (CR-PMNs), in blood (PB-PMNs) and blood monocytes. Furthermore, CR- and PB-PMNs were able to secrete identical amounts of hydrogen peroxide upon stimulation. The chemotactic response of PB-PMNs in the DS child was impaired, however. The results of the studies performed on parameters of specific host defense mechanisms showed low blastogenic responses to phytohemagglutinin (PHA) and pokeweed (PWM) by lymphocytes of the DS child as compared with her sibling. Also a lack of immune regulation leading to prolonged helper/inducer cell activation on a local (gingival) and circulation level and a less pronounced T-cell depression in PB were shown. Together, these differences observed in specific and nonspecific host response mechanisms may be responsible for the earlier and more extensive gingival inflammation found in the DS child.
 ...
PMID:Nonspecific and specific immune responses in a child with Down's syndrome and her sibling. A case report. 296 46

There are numerous correlations between features of acute necrotizing gingivitis (ANG) and virus infections, notably cytomegalovirus (CMV) infections. The age range of occurrence of seroconversions to CMV positive and occurrence of ANG correlate both in industrialized countries (young adults) and in underdeveloped countries (young children). A depression in cell-mediated immunity, as evidenced by a decrease in T-lymphocyte helper/suppressor ratio and decreased responsiveness to the mitogen ConA, has been shown to occur in both CMV infection and ANG. There is a higher incidence of both CMV infection and ANG in young male homosexuals. These and other correlations, taken together, argue for a fundamental role for virus in ANG etiology.
 ...
PMID:A review and proposal for the etiology of acute necrotizing gingivitis. 302 22

Persistent neutropenia (0-0.6 X 10(9) neutrophils/l) was documented during a 10-month period in a 4-year-old spayed female domestic shorthair cat that was presented for anorexia and depression. Salient abnormalities detected on physical examination were fever (40.3 degrees C), dehydration, and gingivitis. The cat was neutropenic (0.5 X 10(9) neutrophils/l) and enzyme-linked immunosorbent assay (ELISA) test for feline leukemia virus was negative. A bone marrow aspirate showed decreased numbers of mature granulocytic cells. In vitro bone marrow cultures for colony-forming units-granulocyte/macrophage (CFU-GM) were performed comparing bone marrow from the patient with that of a normal cat. The patient had fewer CFU-GM than the control. The number of CFU-GM increased when bone marrow mononuclear cells were cultured in the presence of 10(-5) and 10(-6) mol/l of hydrocortisone, but the cat did not respond to oral prednisolone therapy. The pathogenesis of the neutropenia in this cat remains obscure, but resembles the chronic idiopathic neutropenia syndrome of man.
 ...
PMID:Chronic idiopathic neutropenia in a cat. 322 55

Patients with the diagnosis of acute necrotizing ulcerative gingivitis (ANUG) and their controls, matched for age, sex, race and general plaque accumulation, donated blood for differential white blood cell counts and for assay of several leukocyte functions. The leukocyte function assays included polymorphonuclear leukocyte (PMN) responsiveness to chemotaxis and phagocytosis, and lymphocyte responsiveness to stimulation by nonspecific mitogens. The differential leukocyte counts were within the normal range for all subjects tested, and there was no difference between ANUG patients and controls. The ANUG patients did, however, display significantly depressed PMN responsiveness in both chemotaxis and phagocytosis, compared to the controls. There was also reduced DNA synthesis by ANUG patients' lymphocytes upon stimulation by a nonspecific mitogen (Con A). The data presented in this report suggest that depression of some host defense mechanisms, particularly PMN chemotaxis and phagocytosis, may be important in the pathogenesis of ANUG.
 ...
PMID:Leukocyte function in the etiology of acute necrotizing ulcerative gingivitis. 657 77

Inflammatory periodontal disease arises as a response to bacterial plaque. This response, however, may be modified by systemic factors such as nutritional deficiency, hormonal imbalance or severe systemic disease. One such systemic disease that may modify host response to local etiologic factors is systemic lupus erythematosus (SLE). Depression of thrombocyte production is very rarely associated with SLE. A search of the medical literature has revealed only one such reported case. The case history that follows is of a 17-year-old black female with severe gingivitis and spontaneous gingival bleeding associated with systemic lupus erythematosus and amegakaryocytic thrombocytopenia. It is believed to be the first such case reported in the dental literature. The clinical, radiographic and hematologic findings will be presented and the medical and periodontal therapy discussed.
 ...
PMID:Periodontal disease associated with amegakaryocytic thrombocytopenia in systemic lupus erythematosus. 693 47

A lesion in Macaca cyclopis which appears to conform to defined characteristics of noma in human beings has been reported. Clinical features in common include the gangrenous appearance of the lesion, the association with necrotizing ulcerative gingivitis, and the massive destruction of soft tissue and bone in the oronasofacial regions. Systemic features in common include debilitation of the host, leukocytosis, and depression of cellular immunologic responses. Microbiologic studies revealed the presence of organisms commonly found in necrotizing ulcerative gingivitis. The detection of true noma in nonhuman primates may now allow the opportunity for study of the etiology, pathophysiology, and therapy of this condition for human benefit.
 ...
PMID:Noma in a nonhuman primate. 694 71

This study examined the relationship between psychological mood, stress and oral hygiene behaviour in a group of 51 regular dental attenders. Subjects brought a saliva sample for cortisol radioimmunoassay, completed the Hospital Anxiety and Depression (HAD) Scale, were assessed for plaque and gingivitis, and were then instructed in toothbrushing. 5 weeks later, 47 subjects were given a full repeat examination. There was a slight reduction in plaque and gingivitis scores, but no change in mood as assessed by HAD Scale and salivary cortisol concentration. Mean anxiety scores were associated with gingivitis level, and mean depression scores with plaque. Neither mood nor cortisol were predictors of subsequent change in plaque or gingivitis.
 ...
PMID:Psychological mood of regular dental attenders in relation to oral hygiene behaviour and gingival health. 770 39

Five Holstein Friesian calves varying in age from 7 to 9 weeks old, were suspected of suffering from an inherited granulocytopathy known as bovine leucocyte adhesion deficiency (BLAD). Four of them were examined clinically and at necropsy. The most significant clinical findings were fever, depression, weakness, emaciation, diarrhoea, pseudomembranous gingivitis, loose teeth, respiratory infection and occult blood in the faeces. Significant clinicopathological findings were marked leucocytosis, mainly due to a neutrophilia, hypoalbuminemia, hypogammaglobulinemia, increased alpha- and beta-globulins, elevated alkaline phosphatase enzyme activity, hypoglycaemia, and decreased blood urea concentrations. The necropsy revealed emaciated carcasses, granulomatous to necrotising gingivitis, pseudomembranous to necrotising enteritis with perforations, bronchopneumonia, splenic atrophy, and hypoplasia of the thymus. Histopathological examination supported the macroscopic findings.
 ...
PMID:[Suspected inherited granulocytopathy in four Holstein Friesian calves]. 817 99


1 2 Next >>