Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mice infected neonatally with lymphocytic choriomeningitis virus (LCMV) developed partial and complete resitance to cerebral superinfection with tick-borne encephalitis virus (TEV) in 10 and 20 days after birth, respectively. This resistance lasted at least till the age of 40 days. LCMV tolerant mice neither succumbed to TEV infection, nor circulated TEV in their blood. Moderate, gradually decreasing TEV titres were detected in the brains and TEV-induced brain interferon was lower than in control mice of the same age. TEV superinfection caused a significant depression of the blood titre of tolerated LCMV while the titres in the brains remained equal to those in tolerant but not superinfected mice. LCMV tolerant mice showed a similar resistance to another togavirus (chikungunya) but not to encephalitogenic picorna-, herpes- and rhabdoviruses.
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PMID:Selective resistance to togaviral superinfection in mice with tolerant lymphocytic choriomeningitis virus infection. 4 97

Administration in complete Freund's adjuvant of encephalitogenic protein (EP), derived from central nervous tissue to guinea pigs, regularly results in the development of experimental allergic encephalitis (EAE) which leads to the death of the animals. Administration of EP in incomplete Freund's adjuvant at an appropriate time will completely suppress the clinical development of disease. Results reported herein show that animals receiving suppressive injections of EP for 7 days show depression of lymphocyte DNA synthesis and macrophage migration inhibition, but not of skin reactivity, in response to EP immediately following the injections, and subsequently show recovery of lymphocyte reactivity but do not develop clinical manifestations of EAE. Humoral or other factors may prevent the development of disease in these animals. Guinea pigs receiving injections of EP for 14 days show profound and prolonged depression of lymphocyte reactivity to EP and macrophage migration inhibition. Possible mechanisms for these results include a diminished number or function of reactive cells or activity of a population of cells with the capacity to suppress cellular immune responses. Nonspecific suppression of reactivity to an unrelated antigen during the suppressive injections was not observed.
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PMID:Experimental allergic encephalitis: study of cellular immunity during disease suppression. 8 9

Although an effective vaccine exists to protect against VEE, not all persons who may be exposed to this disease are likely to be vaccinated. The disease most often presents as a short febrile illness but the convalescence period may be protracted, and death due to encephalitis does occur in a small percentage of those infected. Knowledge of the metabolic alterations which occur during VEE may materially aid in its treatment. Use of the V-198 strain of VEE in the rat produces a uniform model in which to study metabolic alterations. Changes that occur early in the disease include viremia, neutrophilia, a decrease in plasma zinc and transferrin, and increased amino acid uptake into liver. Plasma zinc depression persists into the later stage of the disease, but to a lesser degree. Increases in plasma copper and seromucoid occur late in the disease, concurrent with the development of pronounced encephalitis. Hypoalbuminemia and decreased ketonemia occur during both the early and late stages of the disease. Taken together, these metabolic alterations appear to chronicle the development of VEE in the rat. If these metabolic alterations can be linked to specific pathogenic processes, they may be useful as prognostic indicators, in formulating supportive therapy, and as monitors of potential antiviral therapy.
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PMID:Host metabolic alterations during Venezuelan equine encephalitis in the rat. 62 26

Verminous encephalitis in a 4-week-old kitten was manifested by depression, hysteria, and terminal convulsions. Necropsy revealed a second instar of Cutebra sp in the right cerebral hemisphere. The main lesions in the brain were those of acute focal hemorrhagic encephalomalacia.
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PMID:Intracerebral migration of Cuterebra larva in a kitten. 62 16

Neurologic signs and neuropathologic lesions associated with a case of equine infectious anemia in a 7 year old Quarter-horse mare were studied. Clinical signs included depression, disorientation, circling, knuckling at the fetlock and hypermetria. The neuropathologic lesions were characterized by a granulomatous ependymitis, subependymal encephalitis, choroiditis and hydrocephalus. These lesions were associated with signs of neurologic dysfunction which were the cause of the prominent clinical features.
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PMID:Neurologic signs and neuropathology associated with a case of equine infectious anemia. 63 20

Sera from 103 fasting individuals 3 to 76 years of age and free of clinical infectious disease and sera from 183 patients with infectious disease were assayed for serum total non-esterfied fatty acids (tNEFA) and compared. Data were also separated into five groups according to age of donor: 3--7, 8--19, 20--35, 36--60, and 61--76 years. The mean group serum levels of tNEFA increased with age. Among patients with infectious diseases sixty-five were diagnosed as having hepatitis, 41 with infectious mononucleosis, 18 with cellulitis, 12 with pulmonary tuberculosis, 11 with non-pneumococcal pneumonia, 9 with pneumococcal pneumonia, 8 with pharyngitis, 6 with pyelonephritis, 6 with aseptic meningitis, 4 with Gram-negative sepsis, and 3 with encephalitis. The sera from 23 non-fasting patients with gonorrhea were also tested. The serum tNEFA levels were found to be altered, in fact depressed from normal group values, only in patients with pneumonia or tuberculosis. This depression may be related to aberrant pulmonary metabolism during pneumonia.
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PMID:Reduced level of non-esterified fatty acids in sera from patients with infectious respiratory disease. 69 41

Sub-lethal i.v. inoculations of Candida albicans into 12-day-old chick embryos have been shown to cause a depression of follicle formation in the bursa of Fabricius. This depression occurred in the absence of any infection in the bursa, although candidal encephalitis was a frequent manifestation of the disseminated infection. A similar depression of bursal follicle formation was caused by the administration of viable C. albicans on to the embryonic chorio-allantoic membrane, in the absence of any disseminated infection. Non-viable extracts of disrupted C. albicans administered on to the chorioallantoic membrane also caused a depression of bursal follicle formation. This immunodeficiency produced by an endotoxin-like principle at a susceptible stage in the development of the chick has been considered in terms of human immunological development and the neonatal occurrence of C. albicans.
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PMID:Depression of bursal follicle formation by Candida albicans infections. 78 98

Twenty-one patients with brucellosis wereinvestigated. Four patients with the classical manifestations of acute brucellosis presented no problems in diagnosis. The other 17 patients suffered from chronic disease and had no history of any acute episode of brucellosis. The most common symptoms in this group were tiredness, fatigue, depression, arthralgia and muscular pains. Abdominal pain and pain in the temperomandibular joints were marked in some patients. Most of these patients had been receiving psychiatric treatment. Clinical examination was largely negative, but lymphadenopathy was found in 9 cases. Brucella meningo-encephalitis was diagnosed in 7 patients who complained of severe headache. Problems in the diagnosis of chronic brucellosis with an insidious onset are discussed.
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PMID:Clinical aspects of chronic brucellosis. 81 22

Records of 11 postmenopausal parkinsonism patients were evaluated in comparison with those of 11 postmenopausal depression patients. None had a history of encephalitis, stroke, drug-induced or toxic extrapyramidal disorders, or active bleeding within six months before admission. There was no significant differences between the two groups with regard to time interval from menopause to onset of symptoms, height, weight, or age at first admission. Both groups showed normal height, hemoglobin, hematocrit, and erythrocyte counts. Parkinsonism patients were underweight and had a shorter interval from menopause to onset of symptoms (12.4 +/- 1.9 vs. 16.8 +/- 2.5 yr.). These findings are compatible with the hypothesis that in parkinsonism, hereditary predisposition to positive body iron balance may be associated with alteration of the blood-brain barrier in parkinsonism.
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PMID:Postmenopausal Parkinsonism: brain iron overload? 93 Jul 48

Gnotobiotic and conventional dogs of different ages were examined for intradermal skin test responses and in virtro peripheral blood lymphocyte responses to the phytomitogens, phytohemagglutinin-P (PHA-P) and pokeweed mitogen (PWM). All adult dogs skin tested with these mitogens demonstrated a positive skin reaction consisting of erythema and induration within 24 hours. In contrast, a positive reaction was obtained only with PHA-P when both mitogens were tested in conventional and gnotobiotic neonatal dogs. Lymphocytes from both adult and neonatal dogs underwent blastogenesis if cultured with PHA-P and PWM. Infection of gnotobiotic dogs with canine distemper virus (CDV) resulted in depression of PHA-P skin test response along with in vitro depression of lymphocyte blastogenesis. Persistent loss of skin test response correlated with eventual death due to CDV-associated encephalitis, whereas dogs which responded to PHA-P 14 to 21 days after viral inoculation survived CDV infection. The results of this study indicated that intradermal mitogen tests can be used as a rapid method for in vivo assessment of cell-mediated immunity in this species.
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PMID:Intradermal mitogen response in dogs: correlation with outcome of infection by canine distemper virus. 93 Nov 36


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