Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We address a key issue at the intersection of emotion, psychopathology, and public health-the startling lack of attention to people who experience benign outcomes, and even flourish, after recovering from depression. A rereading of the epidemiological literature suggests that the orthodox view of depression as chronic, recurrent, and lifelong is overstated. A significant subset of people recover and thrive after depression, yet research on such individuals has been rare. To facilitate work on this topic, we present a generative research framework. This framework includes (a) a proposed definition of healthy end-state functioning that goes beyond a reduction in clinical symptoms, (b) recommendations for specific measures to assess high functioning, and (c) a road map for a research agenda aimed at discovering how and why people flourish after emotional disturbance. Given that depression remains the most burdensome health condition worldwide, focus on what makes these excellent outcomes possible has enormous significance for the public health.
 ...
PMID:The Curious Neglect of High Functioning After Psychopathology: The Case of Depression. 3021 57

This study investigated the degree of brain functional impairment in persistent somatoform pain disorder (PSPD) by examining changes in the patterns of brain functional hubs. Resting-state functional magnetic resonance imaging was performed in 21 PSPD patients with headache as the main symptom and 17 sex- and age-matched healthy controls. Degree centrality (DC) analysis as well as the connectivity among these hubs by functional connectivity (FC) analysis and Granger causality analysis (GCA) were performed to characterize abnormal brain networks in PSPD (Gaussian random field corrected: P < 0.001, Z > 3.09). The relationships between DC and connectivity and clinical parameters were also examined. DC values in the bilateral inferior occipital gyrus (IOG), bilateral calcarine fissure (CAL), and left paracentral lobule (PCL) and FC values of right IOG-left CAL, right IOG-right CAL, right IOG-left IOG, left CAL-right CAL, left CAL-left IOG, left CAL-left PCL, right CAL-left PCL, and left IOG-left PCL were lower in PSPD patients as compared to controls. A negative causal effect from the left CAL to the left paracentral lobule and a positive effect from the right CAL to the right IOG were observed in PSPD patients. Abnormal DC, FC, and signed-path coefficients in PSPD patients were negatively correlated with self-rating anxiety and depression scale scores. These results indicate that altered functional hubs and connectivity patterns in the somatosensory cortex may reflect emotional disturbance in PSPD patients.
 ...
PMID:Altered Brain Functional Hubs and Connectivity Underlie Persistent Somatoform Pain Disorder. 3111 77

Oral lichen planus (OLP) is a chronic immune-mediated, inflammatory, and psychosomatic condition that frequently affects the oral mucosa in a typical bilateral pattern, often noticed in middle-aged females.1 It involves the buccal, lingual, and/or gingival mucosa and is also an oral potentially malignant disorder (OPMD). OLP is associated with etiological factors ranging from viruses like hepatitis C, systemic factors like thyroid disorders,2 local factors like dental plaque, calculus and cuspal trauma, to deep rooted, often underestimated, psychological triggers. OLP is routinely encountered in oral medicine clinics and is sometimes accompanied by the simultaneous involvement of skin, nails, genitals, and/or mucous membranes. Although OLP is multifactorial in origin, a large share of these presentations can be attributed chiefly to psychological factors like stress, anxiety, and depression. OLP is even more striking as its genesis, progression, and exacerbation closely mirror the dynamics of emotional disturbance.
 ...
PMID:A Holistic Intervention for Oral Lichen Planus. 3159 92

The novel coronavirus disease 2019 (COVID-19) has become a pandemic affecting health and wellbeing globally. In addition to the physical health, economic, and social implications, the psychological impacts of this pandemic are increasingly being reported in the scientific literature. This narrative review reflected on scholarly articles on the epidemiology of mental health problems in COVID-19. The current literature suggests that people affected by COVID-19 may have a high burden of mental health problems, including depression, anxiety disorders, stress, panic attack, irrational anger, impulsivity, somatization disorder, sleep disorders, emotional disturbance, posttraumatic stress symptoms, and suicidal behavior. Moreover, several factors associated with mental health problems in COVID-19 are found, which include age, gender, marital status, education, occupation, income, place of living, close contact with people with COVID-19, comorbid physical and mental health problems, exposure to COVID-19 related news and social media, coping styles, stigma, psychosocial support, health communication, confidence in health services, personal protective measures, risk of contracting COVID-19, and perceived likelihood of survival. Furthermore, the epidemiological distribution of mental health problems and associated factors were heterogeneous among the general public, COVID-19 patients, and healthcare providers. The current evidence suggests that a psychiatric epidemic is cooccurring with the COVID-19 pandemic, which necessitates the attention of the global health community. Future epidemiological studies should emphasize on psychopathological variations and temporality of mental health problems in different populations. Nonetheless, multipronged interventions should be developed and adopted to address the existing psychosocial challenges and promote mental health amid the COVID-19 pandemic.
 ...
PMID:Epidemiology of mental health problems in COVID-19: a review. 3309 46

Major depressive disorder (MDD) is a highly prevalent mental disorder that is typically characterized by pervasive and persistent low mood. This durable emotional disturbance may represent a key aspect of the neuropathology of MDD, typified by the wide-ranging distribution of brain alterations involved in emotion processing. However, little is known about whether these alterations are represented as the state properties of dynamic amplitude of low-frequency fluctuation (dALFF) variability in the emotion network. To address this question, we investigated the time-varying intrinsic brain activity derived from resting-state functional magnetic resonance imaging (R-fMRI). Data were obtained from 50 MDD patients and 37 sex- and age-matched healthy controls; a sliding-window method was used to assess dALFF in the emotion network, and two reoccurring dALFF states throughout the entire R-fMRI scan were then identified using a k-means clustering method. The results showed that MDD patients had a significant decrease in dALFF variability in the emotion network and its three modules located in the lateral paralimbic, media posterior, and visual association regions. Altered state-wise dALFF was also observed in MDD patients. Specifically, we found that these altered dALFF measurements in the emotion network were related to scores on the Hamilton Rating Scale for Depression (HAMD) among patients with MDD. The detection and estimation of these temporal dynamic alterations could advance our knowledge about the brain mechanisms underlying emotional dysfunction in MDD.
 ...
PMID:Aberrant state-related dynamic amplitude of low-frequency fluctuations of the emotion network in major depressive disorder. 3330 51


<< Previous 1 2 3 4 5 6 7 8