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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Depressive disorders which masked by somatic symptoms is called masked depression. Masked depression is not a specific type of depression, but the general practitioners often misdiagnose it, because patients complain only somatic symptoms and most practitioners are not aware of it belongs to depression. Usually masked depression is mild, but is apt to chronic, and some patients become worse and might attempt suicide. The cause of depression is still obscure, but according to the results of many somatic tests, somatic findings are important. And differential diagnosis is also important. Concerning the treatment of mild depression, the patients dislike usual antidepressants because of the side effects. Then the author recommend to use a small dose of the drugs and some oriental herbal medicines. Oriental herbal medicines have fewer side effects, and effective for vegetative symptoms.
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PMID:[Masked depression]. 800

The study was carried out in the Family Planning Center of Sir Salimullah Medical College, Mitford Hospital and Family Planning Center of Dhaka Medical College Hospital, Dhaka. 100 sterilized women were selected randomly within 6 months of sterilization during the period of July 1991 to December 1991. They were interviewed by a questionnaire collecting information on sociodemographic parameters, sterilization, and life events. Depressive disorder was assessed by applying the DSM III-R criteria for Major Depressive Episode (MDE). Then the Hamilton Rating Scale for Depression (HRSD) was applied. 19 were suffering from depressive disorder (MDE). Of these, 3 were severe, 8 were moderate, and 8 were mild. Their ages ranged from 21 to 38 years. 42.11% of the depressive cases were in the 26-30 age group. 84% of both groups were either illiterate or had primary education, and 86% were housewives. 78% were urban and 22% were rural residents, respectively. 52% were in the low and 41% were in the middle income category. 35.8% of the nondepressive group had 4 children at the time of operation, while 36.93% of the depressive group had 6 children (p 0.05). Abdominal pain occurred in 23 instances, while only 2% had pain, swelling, and fever. 46 (56.79%) of the nondepressive group had experienced no momentous life events 1 year prior to the interview. In contrast, only 2 (10.54%) of the depressive group had not experienced such life events. Relationship problems in both the nondepressive and depressive groups featured with 24 (29.63%) and 12 (63.16%) cases, respectively, (p 0.05). 3 (15.79%) of the depressive group had past history of anxiety disorder and 2 (10.5%) had previous history of depressive disorder. On the basis of DSM III-R, 18 (94.74%) of the depressive group had mood disorders as the main symptom. 16 each had insomnia and fatigability. 12 (63.16%) of the depressives were retarded and 10 subjects contemplated suicide. HRSD further revealed that all depressive patients had anxiety, and only 2 were receiving antidepressants. Among all patients there were 5 cases of family history of schizophrenia, 2 cases of depressive disorders, and 1 case of bipolar mood disorder in first degree relatives.
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PMID:Pattern of depressive disorder among the permanent sterilized women. 816 34

Depressive disorders occur in Parkinson's disease in about 40%. They often manifest--not seldom preceding diagnosis of Parkinson's syndrome--like monopolar depression. Their cause has not yet been explained in a satisfactory way. Neurotransmitter disturbances are discussed as well as psychogenic factors. There seems to be a subtype of Parkinson's disease with more frequent depression, which is characterized by increased rigidity and bradykinesia, lower age at onset and family history of Parkinson's disease. Especially antidepressants, but also sleep deprivation and electroconvulsive therapy are efficient. The review is illustrated by a case report.
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PMID:[Depression in Parkinson disease. A literature review]. 818 90

Depressive disorders are common among old people in residential and nursing homes. Outside Australia the prevalence rate for depressive symptoms in homes ranges from 30-75% while that for depressive disorders defined by psychiatric diagnostic criteria is well over 20% in many nursing home studies. These rates are between two and twenty times higher than those found among the elderly living at home. Evidence from Australia indicates that a problem of similar magnitude exists here. While physical disability is strongly associated with depression in these populations, it is not the only factor likely to be responsible for the initiation and maintenance of depression among those in long-term care. There is an urgent need for studies which will better define likely aetiological and maintaining factors for depression in institutional populations, as well as controlled trials of both pharmacological treatments and environmental improvements. In addition, research is needed to establish whether depression is an independent risk factor for mortality among institutional residents.
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PMID:Depressive disorders among elderly people in long-term institutional care. 825 Jul 80

This paper presents findings from a multisite study of 126 subjects meeting DSM-III-R criteria for Panic Disorder who also met criteria for a concurrent Major Depressive Episode, Dysthymia, or Depressive Disorder NOS. The study's primary aim was to discern the influence of varying degrees of depression on the comparative efficacy of alprazolam, imipramine and placebo on anxiety outcomes. A placebo-controlled, double-blind, parallel random assignment design was utilized over a total of 16 weeks. There was no medication effect on panic outcomes. At endpoint, percent of anticipatory anxiety (i.e., time spent worrying about having an anxiety attack) was significantly lower in the patients taking active medications vs. placebo. Phobic measures were significantly improved by alprazolam, vs. both imipramine and placebo early in the study; however, by week 8 both active medications were equally superior to placebo in the reduction of phobic symptoms. In addition, both active medications were significantly more effective than placebo in reducing depression. The same efficacy pattern (i.e., active medications superior to placebo) was observed on measures of general functioning. Importantly, there were no significant interactions observed between medication and presence of major depression on the depression measures, indicating that both alprazolam and imipramine were equally efficacious in treating the depression in patients with panic disorder and major depression. Since the patients enrolled in this study suffered from major depressive disorder in the mild to moderate severity range, these results may not be transferrable to patients with panic disorder and severe major depression.
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PMID:Influence of depression on the treatment of panic disorder with imipramine, alprazolam and placebo. 832 78

Depressive illness is the most common emotional disorder in those of advanced age, occurring in approximately one seventh of those over 65 years old. Despite its high prevalence, depression in the elderly is more complicated to diagnose and treat than depression in younger adults. Successful pharmacotherapy for depression in the elderly requires careful consideration of the pharmacodynamics and pharmacokinetics of antidepressant medications of various classes to balance the therapeutic effects and side effect profiles of these agents. The heterocyclic antidepressants are effective in the elderly, but their use in this population may be limited by anticholinergic and/or cardiovascular side effects. The monoamine oxidase inhibitors also are effective, but compliance problems limit their usefulness in older persons. The serotonin selective reuptake inhibitors have been shown to be effective in the elderly, and their side effect profiles are generally milder than those of the older agents. Elderly patients receiving psychotropic drug therapy must be monitored carefully because treatment failure due to undermedication and drug toxicity due to overmedication may have more severe consequences in older than in younger adults.
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PMID:Pharmacologic treatment of depression in the elderly. 844 31

Depressive illness is common in the general population, with a prevalence of 5 percent. However, 10 to 15 percent of any general medical population has clinically significant depression; in patients with selected chronic illnesses, prevalence rates between 25 to 50 percent are noted. In patients with coexisting medical illness, the diagnosis of depression requires differentiating symptoms of the medical illness from symptoms of the comorbid depression. The Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) can be helpful in this endeavor. An understanding of the effect of particular medications on neurotransmitters is required and can guide the clinician in selecting therapeutic agents that have a low incidence of side effects and toxicity.
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PMID:Management of depression in patients with coexisting medical illness. 862 24

Patients with Cushing's syndrome were studied (n = 209, 78% females). Control patients had pituitary adenomas secreting growth hormone or prolactin. Age at diagnosis of Cushing's syndrome was 8-74 (mean 39) years. Duration of symptoms was 0.2-9 (median 2.0) years. Adverse life events within the 2 years preceding the onset of Cushing's syndrome were not significantly commoner than in controls. Depressive illnesses were associated with the presence of adverse life events (p < 0.001). Depressive illness was more common in females (p < 0.01). There were no significant differences in the severity of depression in the different types of Cushing's syndrome. Pathological anxiety had been diagnosed in 26 patients (12%), mania or hypomania in six patients (3%) and confusion in three patients (1%). Psychotic illness had been diagnosed in 16 patients (8%) and was more common in adrenal carcinomas (p < 0.01). Significant psychiatric illness, usually depressive, preceded the onset of all symptoms and signs of Cushing's syndrome in 25 patients (12%); 23 of these developed pituitary Cushing's disease, and two adrenal adenomas. When Cushing's syndrome was diagnosed, significant psychiatric illness, usually depression, was present or had been a feature of Cushing's syndrome in 120 (57%) patients.
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PMID:Psychiatric aspects of Cushing's syndrome. 875 96

Depressive disorder causes cognitive symptoms. In the case of severe cognitive symptoms or when psychometric procedures measure cognitive decline in the range of dementia, depressed patients may be diagnosed as Depressive Pseudo-Dementia (DPD). There is no data that depressive disorder can cause dementia without coexisting depressive symptoms. The latter symptoms are frequently overseen because cognitive symptoms are equated with organic brain disease. There are typical neuropsychological features of cognitive decline in depressive disorders, like psychomotor retardation and the slow-start phenomenon. Most patients referred to as DPD, suffer from depression-induced cognitive symptoms outside the range of dementia, but complain of memory disturbance and inability to think or concentrate. The diagnosis of DPD draws attention to a problem in the diagnosis of psychiatric disorders in the elderly: Old people suffering from depression are at particular risk of being labelled as demented. The most important step to diagnose depression causing dementia is the search for signs and symptoms of affective disorder even after having found cognitive symptoms.
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PMID:The spectrum of depressive pseudo-dementia. 884 66

Depressive illness in adolescence is common. It can also be life-threatening, disabling, chronic, recurrent and occasionally it can progress to a bipolar disorder. Regrettably, the diagnosis is often missed. The features of depression in this age group are generally similar to those in adults but there are potential differences. Engaging the patient and assessing safety are key components of the first interview. Treatment options for the GP include psychological and pharmacological approaches. The evidence for the effectiveness of antidepressants is not as compelling as in depressed adults. When antidepressants are indicated, the newer antidepressants are preferable. Knowing when to refer to specialist agencies is an important aspect of management.
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PMID:Depression in adolescence. 893 39


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