Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Obsessive-compulsive personality disorder (OCPD) remains understudied despite its high community prevalence and substantial societal burden. Elucidating the factors involved in OCPD traits and behaviors could improve conceptual models of OCPD and guide treatment development. Intolerance of uncertainty (IU) has been investigated as a transdiagnostic factor linked to many conditions, including anxiety disorders and obsessive-compulsive disorder (OCD). Despite OCPD's links to OCD, very little research has investigated whether IU may also be a relevant factor in OCPD. The present study administered measures of IU and OCPD to a large community sample of adults (n = 534) as well as a group of individuals with self-identified OCPD (n = 76). The OCPD measure assessed five OCPD trait dimensions as well as overall OCPD severity. We also included measures of other symptoms (OCD, depression, anxiety, and stress) as well as quality of life. Results revealed that the OCPD group reported heightened IU compared with the community sample, even when controlling for group differences in anxiety, depression, stress, and OCD symptoms. IU was significantly correlated with OCPD trait severity, and regression analyses demonstrated that IU predicted severity of OCPD traits controlling for distress symptoms. Moreover, IU significantly mediated the relationship between OCPD traits and reduced quality of life. These results highlight the importance of considering IU in the context of OCPD, with possible implications for improving treatment. Limitations and future directions for research are discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
 ...
PMID:Intolerance of uncertainty and obsessive-compulsive personality disorder. 3206 17

Impaired decision-making is well documented in obsessive-compulsive disorder (OCD) and a range of electrophysiological and functional neuroimaging measures have begun to reveal the pathological mechanisms that underlie the decision-making process. Obsessive-compulsive personality disorder (OCPD) has core symptoms that often overlap with OCD, but similarities between these disorders at the behavioral and neurological levels are often unclear, including whether OCPD exhibits similar decision-making deficits and shared neurological dysfunction. To address these issues, we examined 24 cases of OCD, 19 cases of OCPD, and 26 matched normal control (NC) subjects during the revised Iowa Gambling Task (IGT) using event-related potentials (ERPs). The net IGT scores were lower for OCD subjects than for OCPD or NC subjects, thus indicating that OCD subjects chose more disadvantageous options and were "short-sighted" with regards to information. The feedback-related negativity (FRN) waveform (lose-win) was larger in both OCD and OCPD subjects, which suggested that obstacles exist in the feedback process. Consequently, these subjects might share similar neural mechanisms under ambiguous decision-making circumstances. Furthermore, IGT net scores were significantly and negatively correlated with Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD) scales. This implies that more severe obsessive-compulsive symptoms inspired more negative emotions that led to worse decision-making ability. Therefore, although similar neural mechanisms might exist, this led to different behaviors in which OCPD is associated with better behavioral performance compared to OCD patients.
 ...
PMID:Do Individuals With Obsessive-Compulsive Disorder and Obsessive-Compulsive Personality Disorder Share Similar Neural Mechanisms of Decision-Making Under Ambiguous Circumstances? 3319 20


<< Previous 1 2 3